Composition and Method for Preventing, Reducing, Alleviating or Treating Idiopathic Vomiting

• US 20140271949A1
• Filed: 03/06/2014
• Published: 09/18/2014
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Mars Incorporated
• Original Assignee: IAMS Company (Mars Incorporated)
• Inventors: Park, Jean Soon, Hu, Ping, Lin, Yakang, Reinsalu, Lori Ann
• Granted Patent: US 10,548,935 B2
• Time in Patent Office: Days
• US Class Current: 424/739
• CPC Class Codes: A23K 20/00 Accessory food factors for animal feeding-stuffs
• CPC Class Codes: A23K 50/40 for carnivorous animals, e.g. cats or dogs
• CPC Class Codes: A61K 31/12 Ketones
• CPC Class Codes: A61K 31/22 of acyclic acids, e.g. pravastatin
• CPC Class Codes: A61K 31/341 not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/365 Lactones
• CPC Class Codes: A61K 31/409 having four such rings, e.g. porphine derivatives, bilirubin, biliverdine hemin, hematin A61K31/555
• CPC Class Codes: A61K 31/4353 ortho- or peri-condensed with heterocyclic ring systems
• CPC Class Codes: A61K 31/4402 only substituted in position 2, e.g. pheniramine, bisacodyl
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 31/593 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
• CPC Class Codes: A61K 36/54 Lauraceae (Laurel family), e.g. cinnamon or sassafras
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/08 for nausea, cinetosis or vertigo; Antiemetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Compositions containing one or more compounds with inhibitory effect on a 5-HT3a and/or NK-1 receptor are effective for preventing or treating idiopathic vomiting in a mammal.

Claims

1. A dietary composition for preventing or treating idiopathic vomiting in a companion animal, comprising one or more compounds in an effective amount for inhibiting a 5-hydroxytryptamine-3a serotonin (5-HT3a) receptor and/or a neurokinin-1 (NK-1) receptor, wherein said one or more compounds are selected from the group consisting of ubiquinone-O (CAS NO. 605-94-7), resveratrol (CAS No. 501-36-0), 1,4-benzenediol, 2,3-dimethyl-(9CI) (CAS NO. 608-43-5), vetiverol (CAS NO. 89-88-3), 3,6-dihydroxyflavone (CAS NO. 92439-20-8), nonivamide (CAS NO. 2444-46-4), DL-palmitoylcarnitine chloride (CAS NO. 6865-14-1), asiatic acid (CAS NO. 464-92-6), farnesal (CAS NO. 19317-11-4), nootkatone (CAS NO. 4674-50-4), alpha-amylcinnamyl alcohol (CAS NO. 101-85-9), delta-dodecalactone (CAS NO. 713-95-1), gamma-dodecalactone (CAS NO. 2305-05-7), alpha-lonone (CAS NO. 127-41-3), biochanin A (CAS NO. 491-80-5), delta-undecalactone (CAS NO. 104-67-6), delta-tetradecalactone (CAS NO. 2721-22-4), 2-(3-phenylpropyl)pyridine (CAS NO. 2110-18-1), 1,14-tetradecanediol (CAS NO. 19812-64-7), (+)-cedrol (CAS NO. 77-53-2), 3-heptyldihydro-5-methyl-2(3H)-furanone (CAS NO. 40923-64-6), delta-undecalactone (CAS NO. 710-04-3), methyl dihydrojasmonate (CAS NO. 24851-98-7), ethoxyquin (CAS NO. 91-53-2), petroselinic acid (CAS NO. 593-39-5), methyl isoeugenol (CAS NO. 93-16-3), vanillyl butyl ether (CAS NO. 82654-98-6), guiaiacwood oil (CAS NO. 8016-23-7), luteolin (CAS NO. 491-70-3), 18-beta-glycyrrhetic acid (CAS NO. 471-53-4), tributyl citrate (CAS NO. 77-94-1), palmitoleic acid (CAS NO. 373-49-9), bisabolol (CAS NO. 515-69-5), curcumin (CAS NO. 458-37-7), piperine (CAS NO. 94-62-2), flavone (CAS NO. 525-82-6), menthoxypropanediol (CAS NO. 87061-04-9), 4-hydroxychalcone (CAS NO. 2657-25-2), N-propyl-4-hydroxybenzoate (CAS NO. 94-13-3), cholecalciferol VD3 (CAS NO. 67-97-0), oleoresin ginger (CAS NO. 8002-60-6), eicosapentaenoic acid (CAS NO. 10417-94-4), riboflavin VB2 (CAS NO. 83-88-5), phloretin (CAS NO. 60-82-2), menadione (CAS NO. 58-27-5), 3,3′

-diindolylmethane (CAS NO. 1968-05-4), trans,trans-2,4-heptadienal (CAS NO. 4313-03-5), trans-2,cis-6-nonadienol (CAS NO. 557-48-2), trans,trans-2,4-nonadienal (CAS NO. 5910-87-2), trans-4-methoxycinnamaldehyde (CAS NO. 24680-50-0), 4′

-hydroxy-chalcone (CAS NO. 2657-25-2), 2,2′

,4′

-trihydroxy-chalcone (CAS NO. 26962-50-5), hematoporphyrin dihydrochloride (CAS NO. 17696-69-4), phytosphingosine (CAS NO. 554-62-1), benzylidenacetone (CAS NO. 122-57-6), genistein (CAS NO. 446-72-0), apigenin (CAS NO. 520-36-5), chalcone (CAS NO. 614-47-1), cinnamon bark oil (CAS NO. 8015-91-6), and derivatives and combinations thereof.

2. The dietary composition of claim 1, wherein said dietary composition is a pet food comprising from 0.1 ppm to 75000 ppm of said one or more compounds, and wherein said pet food further comprises a source of carbohydrate, a source of protein, and optionally a source of fat.

3. The dietary composition of claim 2, wherein said dietary composition is a nutritionally balanced pet food for a domestic cat.

4. The dietary composition of claim 1, wherein said composition is a pet food supplement that is capable of being fed to the companion animal either separately from or in combination with a pet food, wherein said pet food supplement comprises from 0.1% to 99% of said one or more compounds by weight.

5. A kit for treating preventing or treating idiopathic vomiting in a companion animal, comprising:

(a) a dietary composition of claim 1;

(b) instructions for feeding said companion animal with the dietary composition, wherein the instructions comprises information selected from the group consisting of;

assessing the severity of the idiopathic vomiting condition of the companion animal;

frequency of feeding;

duration of feeding;

mode of feeding; and

monitoring the idiopathic vomiting condition of the companion animal to determine when to modify the frequency and/or the duration of feeding.

6. The kit of claim 5, wherein the companion animal is a domestic cat.

7. A method for preventing or treating idiopathic vomiting in a companion animal, comprising the step of orally administering to said companion animal one or more compounds in an effective amount for inhibiting the 5-hydroxytryptamine-3 (5-HT₃) receptor and/or the neurokinin-1 (NK-1) receptor, wherein said one or more compounds are selected from the group consisting of ubiquinone-O (CAS NO. 605-94-7), resveratrol (CAS No. 501-36-0), 1,4-benzenediol, 2,3-dimethyl-(9CI) (CAS NO. 608-43-5), vetiverol (CAS NO. 89-88-3), 3,6-dihydroxyflavone (CAS NO. 92439-20-8), nonivamide (CAS NO. 2444-46-4), DL-palmitoylcarnitine chloride (CAS NO. 6865-14-1), asiatic acid (CAS NO. 464-92-6), farnesal (CAS NO. 19317-11-4), nootkatone (CAS NO. 4674-50-4), alpha-amylcinnamyl alcohol (CAS NO. 101-85-9), delta-dodecalactone (CAS NO. 713-95-1), gamma-dodecalactone (CAS NO. 2305-05-7), alpha-lonone (CAS NO. 127-41-3), biochanin A (CAS NO. 491-80-5), sclareolide (CAS NO. 564-20-5), delta-undecalactone (CAS NO. 104-67-6), delta-tetradecalactone (CAS NO. 2721-22-4), 2-(3-phenylpropyl)pyridine (CAS NO. 2110-18-1), 4′

-methoxyflavone (CAS NO. 4143-74-2), (+)-cedrol (CAS NO. 77-53-2), 3-heptyldihydro-5-methyl-2(3H)-furanone (CAS NO. 40923-64-6), delta-undecalactone (CAS NO. 710-04-3), methyl dihydrojasmonate (CAS NO. 24851-98-7), 3,3′

-diindolylmethane (CAS NO. 1968-05-4), petroselinic acid (CAS NO. 593-39-5), methyl isoeugenol (CAS NO. 93-16-3), vanillyl butyl ether (CAS NO. 82654-98-6), guiaiacwood oil (CAS NO. 8016-23-7), luteolin (CAS NO. 491-70-3), phloretin (CAS NO. 60-82-2), 18-beta-glycyrrhetic acid (CAS NO. 471-53-4), tributyl citrate (CAS NO. 77-94-1), palmitoleic acid (CAS NO. 373-49-9), baicalein (CAS NO. 491-67-8), piperine (CAS NO. 94-62-2), flavone (CAS NO. 525-82-6), oleic acid (CAS NO. 112-80-1), trans,trans-2,4-heptadienal (CAS NO. 4313-03-5), trans-2,cis-6-nonadienol (CAS NO. 557-48-2), trans,trans-2,4-nonadienal (CAS NO. 5910-87-2), trans-4-methoxycinnamaldehyde (CAS NO. 24680-50-0), beta-ionol (CAS NO. 22029-76-1), betulinic acid (CAS NO. 472-15-1), benzylidenacetone (CAS NO. 122-57-6), genistein (CAS NO. 446-72-0), apigenin (CAS NO. 520-36-5), 4-hydroxychalcone (CAS NO. 2657-25-2), n-Propyl-4-hydroxybenzoate (CAS NO. 94-13-3), and derivatives and combinations thereof.

8. The method of claim 7, wherein said one or more compounds are orally administered to the companion animal as a part of a dietary composition.

9. The method of claim 8, wherein said dietary composition is a pet food comprising from 0.1 ppm to 50,000 ppm of said one or more compounds, and wherein said pet food further comprises a source of carbohydrate, a source of protein, and optionally a source of fat.

10. The method of claim 8, wherein the pet food is a complete and nutritionally balanced diet for a domestic cat.

11. The method of claim 8, wherein said dietary composition is a pet food supplement comprising from 0.1% to 99% of said one or more compounds thereof by weight, and wherein the step of orally administering comprises feeding the pet food supplement to the companion animal either separately from or in combination with a pet food.

12. The method of claim 8, wherein said dietary composition is orally administered to the companion animal at a frequency ranging from once a month to six times a day.

13. The method of claim 8, wherein said dietary composition is orally administered to the companion animal for a duration ranging from five days to twenty five years.

14. A composition for preventing or treating idiopathic vomiting in a companion animal, comprising one or more compounds in an effective amount for inhibiting a 5-hydroxytryptamine-3a serotonin (5-HT3a) receptor and/or a neurokinin-1 (NK-1) receptor, wherein said one or more compounds are selected from the group consisting of ubiquinone-O (CAS NO. 605-94-7), resveratrol (CAS No. 501-36-0), 1,4-benzenediol, 2,3-dimethyl-(9CI) (CAS NO. 608-43-5), vetiverol (CAS NO. 89-88-3), 3,6-dihydroxyflavone (CAS NO. 92439-20-8), nonivamide (CAS NO. 2444-46-4), DL-palmitoylcarnitine chloride (CAS NO. 6865-14-1), asiatic acid (CAS NO. 464-92-6), farnesal (CAS NO. 19317-11-4), nootkatone (CAS NO. 4674-50-4), alpha-amylcinnamyl alcohol (CAS NO. 101-85-9), delta-dodecalactone (CAS NO. 713-95-1), gamma-dodecalactone (CAS NO. 2305-05-7), alpha-lonone (CAS NO. 127-41-3), biochanin A (CAS NO. 491-80-5), delta-undecalactone (CAS NO. 104-67-6), delta-tetradecalactone (CAS NO. 2721-22-4), 2-(3-phenylpropyl)pyridine (CAS NO. 2110-18-1), 1,14-tetradecanediol (CAS NO. 19812-64-7), (+)-cedrol (CAS NO. 77-53-2), 3-heptyldihydro-5-methyl-2(3H)-furanone (CAS NO. 40923-64-6), delta-undecalactone (CAS NO. 710-04-3), methyl dihydrojasmonate (CAS NO. 24851-98-7), ethoxyquin (CAS NO. 91-53-2), petroselinic acid (CAS NO. 593-39-5), methyl isoeugenol (CAS NO. 93-16-3), vanillyl butyl ether (CAS NO. 82654-98-6), guiaiacwood oil (CAS NO. 8016-23-7), luteolin (CAS NO. 491-70-3), 18-beta-glycyrrhetic acid (CAS NO. 471-53-4), tributyl citrate (CAS NO. 77-94-1), palmitoleic acid (CAS NO. 373-49-9), bisabolol (CAS NO. 515-69-5), curcumin (CAS NO. 458-37-7), piperine (CAS NO. 94-62-2), flavone (CAS NO. 525-82-6), menthoxypropanediol (CAS NO. 87061-04-9), 4-hydroxychalcone (CAS NO. 2657-25-2), N-propyl-4-hydroxybenzoate (CAS NO. 94-13-3), cholecalciferol VD3 (CAS NO. 67-97-0), oleoresin ginger (CAS NO. 8002-60-6), eicosapentaenoic acid (CAS NO. 10417-94-4), riboflavin VB2 (CAS NO. 83-88-5), phloretin (CAS NO. 60-82-2), menadione (CAS NO. 58-27-5), 3,3′

-diindolylmethane (CAS NO. 1968-05-4), trans,trans-2,4-heptadienal (CAS NO. 4313-03-5), trans-2,cis-6-nonadienol (CAS NO. 557-48-2), trans,trans-2,4-nonadienal (CAS NO. 5910-87-2), trans-4-methoxycinnamaldehyde (CAS NO. 24680-50-0), 4′

-hydroxy-chalcone (CAS NO. 2657-25-2), 2,2′

,4′

-trihydroxy-chalcone (CAS NO. 26962-50-5), hematoporphyrin dihydrochloride (CAS NO. 17696-69-4), phytosphingosine (CAS NO. 554-62-1), benzylidenacetone (CAS NO. 122-57-6), genistein (CAS NO. 446-72-0), apigenin (CAS NO. 520-36-5), chalcone (CAS NO. 614-47-1), cinnamon bark oil (CAS NO. 8015-91-6), and derivatives and combinations thereof.

15. The composition of claim 14, wherein the companion animal is a domestic cat.

16. The composition of claim 14, wherein the composition comprises two or more compounds selected from the group consisting of ubiquinone-O (CAS NO. 605-94-7), resveratrol (CAS No. 501-36-0), 1,4-benzenediol, 2,3-dimethyl-(9CI) (CAS NO. 608-43-5), vetiverol (CAS NO. 89-88-3), 3,6-dihydroxyflavone (CAS NO. 92439-20-8), nonivamide (CAS NO. 2444-46-4), DL-palmitoylcarnitine chloride (CAS NO. 6865-14-1), asiatic acid (CAS NO. 464-92-6), farnesal (CAS NO. 19317-11-4), nootkatone (CAS NO. 4674-50-4), alpha-amylcinnamyl alcohol (CAS NO. 101-85-9), delta-dodecalactone (CAS NO. 713-95-1), gamma-dodecalactone (CAS NO. 2305-05-7), alpha-lonone (CAS NO. 127-41-3), biochanin A (CAS NO. 491-80-5), delta-undecalactone (CAS NO. 104-67-6), delta-tetradecalactone (CAS NO. 2721-22-4), 2-(3-phenylpropyl)pyridine (CAS NO. 2110-18-1), 1,14-tetradecanediol (CAS NO. 19812-64-7), (+)-cedrol (CAS NO. 77-53-2), 3-heptyldihydro-5-methyl-2(3H)-furanone (CAS NO. 40923-64-6), delta-undecalactone (CAS NO. 710-04-3), methyl dihydrojasmonate (CAS NO. 24851-98-7), ethoxyquin (CAS NO. 91-53-2), petroselinic acid (CAS NO. 593-39-5), methyl isoeugenol (CAS NO. 93-16-3), vanillyl butyl ether (CAS NO. 82654-98-6), guiaiacwood oil (CAS NO. 8016-23-7), luteolin (CAS NO. 491-70-3), 18-beta-glycyrrhetic acid (CAS NO. 471-53-4), tributyl citrate (CAS NO. 77-94-1), palmitoleic acid (CAS NO. 373-49-9), bisabolol (CAS NO. 515-69-5), curcumin (CAS NO. 458-37-7), piperine (CAS NO. 94-62-2), flavone (CAS NO. 525-82-6), menthoxypropanediol (CAS NO. 87061-04-9), 4-hydroxychalcone (CAS NO. 2657-25-2), N-propyl-4-hydroxybenzoate (CAS NO. 94-13-3), cholecalciferol VD3 (CAS NO. 67-97-0), oleoresin ginger (CAS NO. 8002-60-6), eicosapentaenoic acid (CAS NO. 10417-94-4), riboflavin VB2 (CAS NO. 83-88-5), phloretin (CAS NO. 60-82-2), menadione (CAS NO. 58-27-5), 3,3′

-diindolylmethane (CAS NO. 1968-05-4), trans,trans-2,4-heptadienal (CAS NO. 4313-03-5), trans-2,cis-6-nonadienol (CAS NO. 557-48-2), trans,trans-2,4-nonadienal (CAS NO. 5910-87-2), trans-4-methoxycinnamaldehyde (CAS NO. 24680-50-0), 4′

-hydroxy-chalcone (CAS NO. 2657-25-2), 2,2′

,4′

-trihydroxy-chalcone (CAS NO. 26962-50-5), hematoporphyrin dihydrochloride (CAS NO. 17696-69-4), phytosphingosine (CAS NO. 554-62-1), benzylidenacetone (CAS NO. 122-57-6), genistein (CAS NO. 446-72-0), apigenin (CAS NO. 520-36-5), chalcone (CAS NO. 614-47-1), cinnamon bark oil (CAS NO. 8015-91-6), and derivatives and combinations thereof.

17. The composition of claim 16, wherein the composition comprises three or more compounds selected from the group consisting of ubiquinone-O (CAS NO. 605-94-7), resveratrol (CAS No. 501-36-0), 1,4-benzenediol, 2,3-dimethyl-(9CI) (CAS NO. 608-43-5), vetiverol (CAS NO. 89-88-3), 3,6-dihydroxyflavone (CAS NO. 92439-20-8), nonivamide (CAS NO. 2444-46-4), DL-palmitoylcarnitine chloride (CAS NO. 6865-14-1), asiatic acid (CAS NO. 464-92-6), farnesal (CAS NO. 19317-11-4), nootkatone (CAS NO. 4674-50-4), alpha-amylcinnamyl alcohol (CAS NO. 101-85-9), delta-dodecalactone (CAS NO. 713-95-1), gamma-dodecalactone (CAS NO. 2305-05-7), alpha-lonone (CAS NO. 127-41-3), biochanin A (CAS NO. 491-80-5), delta-undecalactone (CAS NO. 104-67-6), delta-tetradecalactone (CAS NO. 2721-22-4), 2-(3-phenylpropyl)pyridine (CAS NO. 2110-18-1), 1,14-tetradecanediol (CAS NO. 19812-64-7), (+)-cedrol (CAS NO. 77-53-2), 3-heptyldihydro-5-methyl-2(3H)-furanone (CAS NO. 40923-64-6), delta-undecalactone (CAS NO. 710-04-3), methyl dihydrojasmonate (CAS NO. 24851-98-7), ethoxyquin (CAS NO. 91-53-2), petroselinic acid (CAS NO. 593-39-5), methyl isoeugenol (CAS NO. 93-16-3), vanillyl butyl ether (CAS NO. 82654-98-6), guiaiacwood oil (CAS NO. 8016-23-7), luteolin (CAS NO. 491-70-3), 18-beta-glycyrrhetic acid (CAS NO. 471-53-4), tributyl citrate (CAS NO. 77-94-1), palmitoleic acid (CAS NO. 373-49-9), bisabolol (CAS NO. 515-69-5), curcumin (CAS NO. 458-37-7), piperine (CAS NO. 94-62-2), flavone (CAS NO. 525-82-6), menthoxypropanediol (CAS NO. 87061-04-9), 4-hydroxychalcone (CAS NO. 2657-25-2), N-propyl-4-hydroxybenzoate (CAS NO. 94-13-3), cholecalciferol VD3 (CAS NO. 67-97-0), oleoresin ginger (CAS NO. 8002-60-6), eicosapentaenoic acid (CAS NO. 10417-94-4), riboflavin VB2 (CAS NO. 83-88-5), phloretin (CAS NO. 60-82-2), menadione (CAS NO. 58-27-5), 3,3′

-diindolylmethane (CAS NO. 1968-05-4), trans,trans-2,4-heptadienal (CAS NO. 4313-03-5), trans-2,cis-6-nonadienol (CAS NO. 557-48-2), trans,trans-2,4-nonadienal (CAS NO. 5910-87-2), trans-4-methoxycinnamaldehyde (CAS NO. 24680-50-0), 4′

-hydroxy-chalcone (CAS NO. 2657-25-2), 2,2′

,4′

-trihydroxy-chalcone (CAS NO. 26962-50-5), hematoporphyrin dihydrochloride (CAS NO. 17696-69-4), phytosphingosine (CAS NO. 554-62-1), benzylidenacetone (CAS NO. 122-57-6), genistein (CAS NO. 446-72-0), apigenin (CAS NO. 520-36-5), chalcone (CAS NO. 614-47-1), cinnamon bark oil (CAS NO. 8015-91-6), and derivatives and combinations thereof.

18. The composition of claim 14, wherein the composition is suitable for topical or transdermal application.

19. The composition of claim 14, wherein the composition is suitable for intravenous, subcutaneous, or intra-muscular injection.

20. The composition of claim 14, wherein the composition is suitable for rectal administration.