Resorbable Oxidized Cellulose Embolization Microspheres

• US 20140274945A1
• Filed: 03/14/2014
• Published: 09/18/2014
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Blaskovich, Phillip, Ohri, Rachit, Cherniavsky, Olga
• Granted Patent: US 10,328,095 B2
• Time in Patent Office: Days
• US Class Current: 514/57
• CPC Class Codes: A61K 31/717 Celluloses
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices
• CPC Class Codes: C08L 1/04 Oxycellulose; Hydrocellulose , e.g. microcrystalline cellulose

Abstract

A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen.

Claims

1. A method for forming an embolism within a blood vessel comprising:

implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen.

2. The method according to claim 1, further comprising guiding an implantation device comprising the plurality of oxidized cellulose microspheres through the lumen.

3. The method according to claim 2, wherein guiding the implantation device comprises imaging the blood vessel.

4. The method according to claim 1, further comprising contacting the plurality of oxidized cellulose microspheres with a cross-linking agent.

5. The method according to claim 4, wherein the cross-linking agent is an aqueous solution of chitosan having a pH from about 2.0 to about 6.0.

6. The method according to claim 4, wherein the cross-linking agent is an aqueous solution of at least one multivalent cation selected from the group consisting of calcium, barium, zinc, magnesium, chromium, platinum, and iron.

7. The method according to claim 4, wherein the cross-linking agent is selected from the group consisting of water, saline, phosphate buffered saline, and combinations thereof.

8. The method according to claim 4, wherein the cross-linking agent is carboxymethylcellulose in an aqueous solution at a concentration from about 0.5% by weight of the solution to about 5% by weight of the solution.

9. The method according to claim 4, wherein the cross-linking agent is a solution of an acrylic polymer based on at least one of methyl methacrylate, hydroxyethyl acrylate, hydroxyethyl methacrylate, glyceryl acrylate, glyceryl methacrylate, acrylic acid, methacrylic acid, acrylamide, or methacrylamide, and combinations thereof and a solvent selected from the group consisting of acetone, ethyl acetate, dimethyl ether, and combinations thereof.

10. The method according to claim 4, wherein the cross-linking agent comprises a Schiff-base compound selected from the group consisting of amoxicillin, cephalexin, and combinations thereof.

11. The method according to claim 4, wherein the cross-linking agent comprises trilysine, albumin, polyethylene glycol amine, and combinations thereof.

12. A method for treating a tumor comprising:

identifying at least one arterial blood vessel supplying blood to a tumor;

guiding an implantation device comprising a plurality of oxidized cellulose microspheres through a lumen of the at least one arterial blood vessel; and

implanting the plurality of oxidized cellulose microspheres into the lumen through the implantation device to at least partially block the lumen and impede supply of blood to the tumor.

13. The method according to claim 12, wherein guiding the implantation device comprises imaging the at least one arterial blood vessel.

14. The method according to claim 12, further comprising inhibiting swelling of the plurality of oxidized cellulose microspheres.

15. The method according to claim 14, wherein inhibiting swelling of the plurality of oxidized cellulose microspheres comprises contacting the plurality of oxidized cellulose microspheres with at least one cross-linking agent.

16. A method for forming an embolism within a blood vessel comprising:

contacting a plurality of oxidized cellulose microspheres with at least one cross-linking agent; and

implanting the plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen.

17. The method according to claim 16, further comprising guiding an implantation device comprising the plurality of oxidized cellulose microspheres through the lumen.

18. The method according to claim 17, wherein guiding the implantation device comprises imaging the blood vessel.

19. The method according to claim 16, wherein the plurality of oxidized cellulose microspheres are suspended in at least one an aqueous or a lipid medium.

20. The method according to claim 16, wherein the plurality of oxidized cellulose microspheres have a degradation time from about 5 minutes to about 8 weeks.

21. The method according to claim 20, wherein the plurality of oxidized cellulose microspheres comprise an oxidized cellulose solution comprising oxidized cellulose and a solvent, the oxidized cellulose having a degree of oxidation from about 0.2 to about 1.0.

22. The method according to claim 21, wherein the solvent is present in an amount of from about 0.1% by weight to 25% by weight of the oxidized cellulose.