CONTINUOUS OPTODE FLUORESCENT MEASUREMENT SYSTEM
First Claim
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1. An optical sensor (optode) system comprising:
- (i) at least one analyte-specific, light-emitting agent, which emits light in the presence of the analyte;
(ii) a sensor device configured to detect non-invasively the light emitted by the agent, the sensor device comprising a plurality of LEDs, at least one photodiode configured to detect light emitted from the light-emitting agent, an SOC/microprocessor, and transceiver to receive/transmit data wirelessly and, optionally, a photodiode light filter; and
(iii) a display, wherein the system is configured such that the sensor quantifies the in vivo levels or concentration of the analyte and displays the information graphically on the display.
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Abstract
Presently described are systems and methods for the continuous, accurate, low cost measurement of the concentration of target molecule(s), e.g., analytes, such as metabolites and ions, using analyte-specific, light-emitting agents, e.g., fluorescent nanosensors.
12 Citations
15 Claims
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1. An optical sensor (optode) system comprising:
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(i) at least one analyte-specific, light-emitting agent, which emits light in the presence of the analyte; (ii) a sensor device configured to detect non-invasively the light emitted by the agent, the sensor device comprising a plurality of LEDs, at least one photodiode configured to detect light emitted from the light-emitting agent, an SOC/microprocessor, and transceiver to receive/transmit data wirelessly and, optionally, a photodiode light filter; and (iii) a display, wherein the system is configured such that the sensor quantifies the in vivo levels or concentration of the analyte and displays the information graphically on the display. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of monitoring an analyte in a patient non-invasively comprising the steps of:
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administering an analyte-specific, light-emitting agent, which emits light in the presence of the analyte; providing an optical sensor system comprising a sensor device comprising a plurality of LEDs, at least one photodiode configured to detect light emitted from the light-emitting agent, an SOC/microprocessor, a transceiver for receiving/transmitting data wirelessly, and a display, wherein the sensor device is configured to detect and measure non-invasively the light emitted by the agent, calculate the amount or concentration of analyte present; detecting and measuring the intensity of light emitted by the analyte-specific light-emitting agent over a predetermined time course with the sensor device, wherein the sensor device calculates the amount or concentration of analyte present based on the intensity of light emitted by the light-emitting agent over the predetermined time course; transmitting the light emission data to a second processor having a display; displaying graphically the amount or concentration of the analyte detected by the sensor device over the predetermined time course. - View Dependent Claims (11, 13, 14)
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12. The method of claim 12, wherein the LEDs emit light at about 460 nm.
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15. A method for normalizing opamp circuit gain in an LED-based fluorescence detecting sensor device comprising the steps of:
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providing at least two LEDs that provide different intensities of 460 nm wavelength of light, wherein at least one LED is biased with about 5 mA of current, and at least one other LED is biased at 2.5 mA of current; alternating the power to the respective LEDs such that they are ON and OFF at different times; and acquiring analyte measurements with (i) the 5 mA LED ON, and 2.5 mA LED OFF, (ii) the 5 mA LED OFF, and 2.5 mA LED ON, and (iii) both the 5 mA LED ON and the 2.5 mA LED ON.
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Specification