CONTINUOUS NONINVASIVE MEASUREMENT OF ANALYTE CONCENTRATION USING AN OPTICAL BRIDGE
First Claim
1. A method for measuring an analyte in a fluid within a sample with an optical system, comprising:
- directing a radiation beam at the sample, the beam including at least two periods of radiation having different wavelengths, the analyte having different absorption coefficients for the two different wavelengths;
detecting the beam with a detector when the sample is in a first sample fluid state having a first amount of fluid, wherein the detector is configured to generate an output signal proportional to an intensity of the beam at each of the two different wavelengths;
obtaining an estimate of the first amount of fluid;
detecting the beam with the detector when the sample is in a second sample fluid state having a second amount of fluid, wherein the sample transitions from the first sample fluid state to the second sample fluid state by a pulsation of the sample;
obtaining an estimate of the second amount of fluid; and
determining an estimate of a concentration of the analyte in the fluid based on the output signal, the estimate of the first amount of fluid, and the estimate of the second amount of fluid.
1 Assignment
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Accused Products
Abstract
A method may include directing a radiation beam at a sample, the beam including two periods of radiation having different wavelengths, an analyte in a fluid within the sample having different absorption coefficients for the two different wavelengths, detecting the beam with a detector when the sample is in a first fluid state, the detector configured to generate an output signal proportional to an intensity of the beam at each of the two different wavelengths, detecting the beam with the detector when the sample is in a second fluid state, the sample transitioning from the first fluid state to the second fluid state by a pulsation of the sample, obtaining estimates of an amount of fluid at the first and second fluid states, and determining an analyte concentration estimate based on the output signal and the estimate of the amount of fluid at the first and second fluid states.
6 Citations
20 Claims
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1. A method for measuring an analyte in a fluid within a sample with an optical system, comprising:
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directing a radiation beam at the sample, the beam including at least two periods of radiation having different wavelengths, the analyte having different absorption coefficients for the two different wavelengths; detecting the beam with a detector when the sample is in a first sample fluid state having a first amount of fluid, wherein the detector is configured to generate an output signal proportional to an intensity of the beam at each of the two different wavelengths; obtaining an estimate of the first amount of fluid; detecting the beam with the detector when the sample is in a second sample fluid state having a second amount of fluid, wherein the sample transitions from the first sample fluid state to the second sample fluid state by a pulsation of the sample; obtaining an estimate of the second amount of fluid; and determining an estimate of a concentration of the analyte in the fluid based on the output signal, the estimate of the first amount of fluid, and the estimate of the second amount of fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for measuring an analyte in blood within tissue of a subject, comprising:
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directing a radiation beam at the tissue, the beam including at least two periods of radiation having different wavelengths, the analyte having different absorption coefficients for the two different wavelengths; detecting the beam with a detector when the tissue is in a first blood state having a first amount of blood, wherein the detector is configured to generate an output signal proportional to an intensity of the beam at each of the two different wavelengths; obtaining an estimate of the first amount of blood; detecting the beam with the detector when the tissue is in a second blood state having a second amount of blood, wherein the tissue transitions from the first blood state to the second blood state by a pulse from a heartbeat of the subject; obtaining an estimate of the second amount of blood; and determining an estimate of a concentration of the analyte in the blood based on the output signal, the estimate of the first amount of blood, and the estimate of the second amount of blood. - View Dependent Claims (14, 15, 16)
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17. A method for measuring an analyte in a fluid within a sample, comprising:
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directing a radiation beam at the sample, the beam including at least two periods of radiation having different wavelengths, the analyte having different absorption coefficients for the two different wavelengths; detecting the beam with a detector when the sample is in a first sample fluid state having a first amount of fluid, wherein the detector is configured to generate an output signal proportional to an intensity of the beam at each of the two different wavelengths; obtaining an estimate of the first amount of fluid; detecting the beam with the detector when the sample is in a second sample fluid state having a second amount of fluid, wherein the sample transitions from the first sample fluid state to the second sample fluid state by pulsations of the sample; obtaining an estimate of the second amount of fluid; and determining estimates of a concentration of the analyte in the fluid for a predetermined number of pulsations based on the output signals, the estimate of the first amount of fluid, and the estimate of the second amount of fluid. - View Dependent Claims (18, 19, 20)
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Specification