ANALYTE SENSOR APPARATUSES COMPRISING MULTIPLE IMPLANTABLE SENSOR ELEMENTS AND METHODS FOR MAKING AND USING THEM
First Claim
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1. An apparatus for monitoring an analyte in a patient, the apparatus comprising:
- a base adapted to secure the apparatus to the patient;
a first piercing member coupled to and extending from the base;
a first electrochemical sensor operatively coupled to the first piercing member, wherein the first electrochemical sensor comprises a plurality of working, counter and reference electrodes that are grouped together as a unit and positionally distributed in a repeating pattern of units;
a second piercing member coupled to and extending from the base;
a second electrochemical sensor operatively coupled to the second piercing member, wherein the second electrochemical sensor comprises a plurality of working, counter and reference electrodes that are grouped together as a unit and positionally distributed in a repeating pattern of units; and
wherein;
at least one physiological characteristic monitored by the first or the second electrochemical sensor comprises a concentration of a naturally occurring analyte in the patient;
the first and second piercing members are disposed on the base in a configuration selected so that the first piercing member disposes the first electrochemical sensor in a first tissue compartment of the patient and the second piercing member disposes the second electrochemical sensor in a second tissue compartment of the patient; and
the first and second piercing members are disposed on the base in a configuration selected to avoid a physiological response that can result from implantation of the first electrochemical sensor from altering a sensor signal generated by the second electrochemical sensor.
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Abstract
Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.
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Citations
20 Claims
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1. An apparatus for monitoring an analyte in a patient, the apparatus comprising:
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a base adapted to secure the apparatus to the patient; a first piercing member coupled to and extending from the base; a first electrochemical sensor operatively coupled to the first piercing member, wherein the first electrochemical sensor comprises a plurality of working, counter and reference electrodes that are grouped together as a unit and positionally distributed in a repeating pattern of units; a second piercing member coupled to and extending from the base; a second electrochemical sensor operatively coupled to the second piercing member, wherein the second electrochemical sensor comprises a plurality of working, counter and reference electrodes that are grouped together as a unit and positionally distributed in a repeating pattern of units; and
wherein;at least one physiological characteristic monitored by the first or the second electrochemical sensor comprises a concentration of a naturally occurring analyte in the patient; the first and second piercing members are disposed on the base in a configuration selected so that the first piercing member disposes the first electrochemical sensor in a first tissue compartment of the patient and the second piercing member disposes the second electrochemical sensor in a second tissue compartment of the patient; and the first and second piercing members are disposed on the base in a configuration selected to avoid a physiological response that can result from implantation of the first electrochemical sensor from altering a sensor signal generated by the second electrochemical sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An apparatus for monitoring glucose in a patient, the apparatus comprising:
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a base adapted to secure the apparatus to the patient; a first piercing member coupled to and extending from the base element; a first electrochemical sensor operatively coupled to the first piercing member, wherein the first electrochemical sensor comprises a plurality of working, counter and reference electrodes that are grouped together as a unit and positionally distributed in a repeating pattern of units; a second piercing member coupled to and extending from the base; a second electrochemical sensor operatively coupled to the second piercing member, wherein the second electrochemical sensor comprises a plurality of working, counter and reference electrodes that are grouped together as a unit and positionally distributed in a repeating pattern of units; and
wherein;at least one of the first or the second electrochemical sensor monitors a concentration of glucose in the patient; and the first and second piercing members are disposed on the base in a configuration selected so that when the first and second piercing members are inserted into the patient, the first and second sensors are separated by at least 5 millimeters of tissue. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification