BIOINTERFACE MEMBRANES INCORPORATING BIOACTIVE AGENTS
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Abstract
A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
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Citations
32 Claims
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1-20. -20. (canceled)
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21. An implantable continuous glucose sensor system, comprising:
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an implantable transcutaneous continuous glucose sensor configured to measure in vivo a glucose concentration of a host, wherein the sensor comprises; an electroactive surface for sensing a measured species; and a membrane system disposed on at least a portion of the electroactive surface, wherein the membrane system comprises; a biointerface membrane configured to provide an interface between the sensor and an in vivo environment, wherein the biointerface membrane comprises a polyurethane polymer comprising a hydrophilic component; and a sensing membrane comprising an enzyme; and sensor electronics operably connected to the implantable transcutaneous continuous glucose sensor. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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Specification