EXPERT SYSTEM FOR DETERMINING PATIENT TREATMENT RESPONSE
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Abstract
A medical digital expert system to predict a patient'"'"'s response to a variety of treatments (using pre-treatment information) is described. The system utilizes data fusion, advanced signal/information processing and machine learning/inference methodologies and technologies to integrate and explore diverse sets of attributes, parameters and information that are available to select the optimal treatment choice for an individual or for a subset of individuals suffering from any illness or disease including psychiatric, mental or neurological disorders and illnesses. The methodology and system can also be used to determine or confirm medical diagnosis, estimate the level, index, severity or critical medical parameters of the illness or condition, or provide a list of likely diagnoses for an individual suffering/experiencing any illness, disorder or condition.
76 Citations
45 Claims
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1-42. -42. (canceled)
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1. A computer-implemented method for predicting patient response to treatment for a subject patient, the method comprising:
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receiving, for a subject patient, a subject patient dataset including features obtained for a reduced feature dataset; and comparing the subject patient dataset to a feature data scheme to predict a response for the subject patient; wherein the feature data scheme comprises; (a) a diagnostic model for determining a diagnosis of one of a plurality of known disorders indicated by an individual patient dataset; and (b) a plurality of diagnosis-specific treatment response models, each of the diagnosis-specific treatment response models corresponding to a specific diagnosis of one of the known disorders, the treatment response models configured to use feature data to predict treatment response; wherein comparing the subject patient dataset to the feature data scheme to predict the response for the subject patient comprises; applying the diagnostic model to the subject patient dataset to determine a subject patient diagnosis of one of the known disorders indicated for the subject patient by the subject patient dataset; and selecting and applying one of the diagnosis-specific treatment response models to the subject patient dataset to predict the response for the subject patient; wherein the selected diagnosis-specific treatment response model corresponds to the determined subject patient diagnosis. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A medical system comprising:
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a first computer, wherein the first computer comprises; storage for storing a feature data scheme, wherein the feature data scheme comprises; (a) a diagnostic model for determining a diagnosis of one of a plurality of known disorders indicated by an individual patient dataset; and (b) a plurality of diagnosis-specific treatment response models, each of the diagnosis-specific treatment response models corresponding to a specific diagnosis of one of the known disorders, the treatment response models configured to use feature data to predict treatment response; and at least one processor coupled to the storage and to an input device, the processor executing instructions for; receiving, for a subject patient, a subject patient dataset including features obtained for a reduced feature dataset; and comparing the subject patient dataset to a feature data scheme to predict a response for the subject patient; wherein comparing the subject patient dataset to the feature data scheme to predict the response for the subject patient comprises; applying the diagnostic model to the subject patient dataset to determine a subject patient diagnosis of one of the known disorders indicated for the subject patient by the subject patient dataset; and selecting and applying one of the diagnosis-specific treatment response models to the subject patient dataset to predict the response for the subject patient; and wherein the selected diagnosis-specific treatment response model corresponds to the determined subject patient diagnosis. - View Dependent Claims (30, 31, 32, 33)
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34. A computer-implemented method for assessment of status of a patient, the method comprising:
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receiving, for a subject patient, a subject patient dataset including features obtained for a reduced feature dataset; and comparing the subject patient dataset to a feature data scheme to allocate an assessment status for the subject patient; wherein the feature data scheme comprises; (a) a diagnostic model for determining a diagnosis of one of a plurality of known disorders indicated by an individual patient dataset; and (b) a plurality of diagnosis-specific assessment status models, each of the diagnosis-specific assessment status models corresponding to a specific diagnosis of one of the known disorders, the assessment status models configured to use feature data to allocate an assessment status; wherein comparing the subject patient dataset to the feature data scheme to allocate the assessment status for the subject patient comprises; applying the diagnostic model to the subject patient dataset to determine a subject patient diagnosis of one of the known disorders indicated for the subject patient by the subject patient dataset; and selecting and applying one of the diagnosis-specific assessment status models to the subject patient dataset to allocate the assessment status for the subject patient; and wherein the selected diagnosis-specific assessment status model corresponds to the determined subject patient diagnosis. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A medical system comprising:
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a computer, wherein the computer comprises; storage for storing a feature data scheme, wherein the feature data scheme comprises; (a) a diagnostic model for determining a diagnosis of one of a plurality of known disorders indicated by an individual patient dataset; and (b) a plurality of diagnosis-specific assessment status models, each of the diagnosis-specific assessment status models corresponding to a specific diagnosis of one of the known disorders, the assessment status models configured to use feature data to allocate an assessment status; at least one processor coupled to the storage and to an input device, the processor executing instructions for; receiving, for a subject patient, a subject patient dataset including features obtained for a reduced feature dataset; and comparing the subject patient dataset to a feature data scheme to allocate an assessment status for the subject patient; wherein comparing the subject patient dataset to the feature data scheme to allocate the assessment status for the subject patient comprises; applying the diagnostic model to the subject patient dataset to determine a subject patient diagnosis of one of the known disorders indicated for the subject patient by the subject patient dataset; and selecting and applying one of the diagnosis-specific assessment status models to the subject patient dataset to allocate the assessment status for the subject patient; and wherein the selected diagnosis-specific assessment status model corresponds to the determined subject patient diagnosis. - View Dependent Claims (45)
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Specification