COMPOUND, EXTRACT ISOLATED FROM ANTRODIA CAMPHORATE, AND METHOD OF INHIBITING CANCER CELL GROWTH

• US 20140286989A1
• Filed: 08/06/2013
• Published: 09/25/2014
• Est. Priority Date: 03/20/2013
• Status: Abandoned Application

• Current Assignee: Hui Ling Tseng
• Original Assignee: Hui Ling Tseng
• Inventors: YAO, CHEN-WEN, CHANG, WEN-LIANG, YEN, I-CHUAN, TSENG, HUI LING, TSENG, WAN PING, TSENG, TAI LIN, KUO, YIN YU
• Application Number:
  US13/960,696
• Publication Number:
  US 20140286989A1
• Time in Patent Office: Days
• US Class Current: 424/195.15
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 36/07 Basidiomycota, e.g. Cryptococcus
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07C 2601/16 the ring being unsaturated
• CPC Class Codes: C07C 403/08 by hydroxy groups
• CPC Class Codes: C07C 69/02 Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen

Abstract

Disclosed is a compound isolated from Antrodia camphorata, represented by formula I:

wherein R1 is a hydrogen atom or an acetyl group; and a method of inhibiting cancer cell growth by using the compound, the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer.

Claims

1. A compound isolated from Antrodia camphorata, represented by formula I:

2. The compound as claimed in claim 1, wherein R1 is a hydrogen atom, and the compound is represented by formula II:

3. The compound as claimed in claim 1, wherein R1 is an acetyl group, and the compound is represented by formula III:

4. A method of inhibiting cancer cell growth by using the compound as claimed in claim 1, wherein the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer.

5. An extract of Antrodia camphorate for inhibiting cancer cell growth, extracted by the following steps:

extracting a fruiting body, mycelium, or the mixture thereof twice, with an ethanol solution with a ratio of 1;

10 to obtain two ethanol extracts, concentrating the ethanol extracts to yield a crude extract, the crude extract being extracted three times with dichloromethane/water (1;

1) to form a dichloromethane layer and a water layer, the dichloromethane layer being loaded to a layered silica gel column with hexane/dichloromethane (1;

4), dichloromethane, and methanol/dichloromethane (5;

95) to yield the extract.

6. The extract of Antrodia camphorate for inhibiting cancer cell growth as claimed in claim 5, wherein the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer.