COVALENT INHIBITORS OF KRAS G12C
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Accused Products
Abstract
Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.
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Citations
132 Claims
- 1. A compound having the following structure (V):
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2. (canceled)
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8-9. -9. (canceled)
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11. (canceled)
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13-14. -14. (canceled)
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21-24. -24. (canceled)
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26-27. -27. (canceled)
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32. A compound having the following structure (VI):
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33-61. -61. (canceled)
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63-69. -69. (canceled)
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71-76. -76. (canceled)
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78-87. -87. (canceled)
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89-93. -93. (canceled)
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96-101. -101. (canceled)
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103-105. -105. (canceled)
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108-109. -109. (canceled)
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111-115. -115. (canceled)
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117. (canceled)
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119-124. -124. (canceled)
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127-130. -130. (canceled)
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132. (canceled)
Specification