SURFACE TREATED STAPLES, SUTURES AND DENTAL FLOSS AND METHODS OF MANUFACTURING THE SAME

• US 20140288592A1
• Filed: 03/14/2014
• Published: 09/25/2014
• Est. Priority Date: 04/02/2007
• Status: Active Grant

• Current Assignee: Ension, Inc.
• Original Assignee: Ension, Inc.
• Inventors: HUSSAIN, Ali, Cahalan, Linda, Johnson, Greg, Gartner, Mark, Cahalan, Patrick, Fill, Brian J., Speakman, Jeffrey W.
• Granted Patent: US 9,693,841 B2
• Time in Patent Office: Days
• US Class Current: 606/219
• CPC Class Codes: A61B 17/06 Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials puncturing needles A61B17/34; hypodermic needles A61M5/32 ; sewing needles D05B85/00
• CPC Class Codes: A61B 17/06166 Sutures suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M
• CPC Class Codes: A61B 17/064 Surgical staples, i.e. penetrating the tissue
• CPC Class Codes: A61C 15/041 Dental floss chemical aspects A61Q11/00
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/0029 using an intermediate layer of polymer
• CPC Class Codes: A61M 1/1698 Blood oxygenators with or without heat-exchangers intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00
• CPC Class Codes: B05D 1/36 Successively applying liquids or other fluent materials, e.g. without intermediate treatment
• CPC Class Codes: B05D 1/62 Plasma-deposition of organic layers plasma deposition in general C23C14/00, C23C16/00
• CPC Class Codes: B05D 2256/00 Wires or fibres
• CPC Class Codes: B05D 2258/00 Small objects (e.g. screws)
• CPC Class Codes: B05D 3/06 by exposure to radiation B05D3/02 takes precedence ; plasma treatment B05D3/141
• CPC Class Codes: B05D 7/02 to macromolecular substances, e.g. rubber treatment or coating of shaped articles made of macromolecular substances C08J7/00
• CPC Class Codes: C08L 23/12 Polypropene
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

A variety of medical devices including staples sutures and dental floss with surface treatment on at least one tissue-facing surface to improve biologic function such as to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm², and ii) a thrombin deactivation of at least 0.2 IU/cm²; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment.

Claims

1. A method of treating the surface of a surgical closure device with a biomolecule comprising the steps of:

a) providing a polyolefin substrate forming a medical device;

b) cleaning the polyolefin substrate;

c) exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and

d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.

2. The method of treating the surface of a surgical closure device with a biomolecule of claim 1 further including the steps of the exposing the polyolefin substrate to a reactive gas containing siloxane functional groups and plasma energy to yield a plasma-deposited polysiloxane surface on the surface of the polyolefin substrate prior to exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy, and rendering the plasma deposited polysiloxane surface amino functional.

3. The method of treating the surface of a surgical closure device with a biomolecule of claim 2 wherein the biomolecule is heparin.

4. The method of treating the surface of a surgical closure device with a biomolecule of claim 3 wherein the polyolefin substrate is formed of polypropylene.

5. The method of treating the surface of a surgical closure device with a biomolecule of claim 1 wherein the polyolefin substrate forms a surgical closure device in the form of sutures.

6. The method of treating the surface of a surgical closure device with a biomolecule of claim 5 wherein the biomolecule is a growth factor.

7. The method of treating the surface of a surgical closure device with a biomolecule of claim 1 wherein the polyolefin substrate forms a surgical closure device in the form of a surgical staple.

8. The method of treating the surface of a surgical closure device with a biomolecule of claim 1 wherein the biomolecule is decorin.

9. A method of forming a medical device comprising the steps of:

Providing a substrate on a feed reel within a plasma chamber;

Passing the substrate through a pair of electrodes in the plasma chamber;

Providing a take up mandrel within the plasma chamber wherein rotation of the take up mandrel will pull the substrate through a pair of electrodes in the plasma chamber.

10. The method of forming a medical device of claim 9 wherein the plasma chamber is used to activate the substrate, further including intermediate chemistries performed on the substrate followed by attachment of a biomolecule to the substrate.

11. The method of claim of forming a medical device of claim 9 wherein the medical device is dental floss.

12. The method of claim of forming a medical device of claim 9 wherein the medical device is a surgical closure device.

13. The method of claim of forming a medical device of claim 12 wherein the device is a suture material.

14. The method of claim of forming a medical device of claim 13 wherein the biomolecule is decorin.

15. A surgical closing member comprising a substrate;

an acrylamide surface bonded to the substrate and a biomolecule bonded to the acrylamide surface, wherein the surgical closing member is one of a suture material and a surgical staple.

16. A surgical closing member according to claim 15 wherein the surgical closing member is a polyolefin suture material.

17. A surgical closing member according to claim 16 wherein the biomolecule is decorin.

18. A surgical closing member according to claim 15 wherein the surgical closing member is a surgical staple.

19. A surgical closing member according to claim 15 wherein the surgical closing member is an absorbable suture material.

20. A surgical closing member according to claim 19 wherein the biomolecule is decorin.