BIOLOGICAL DETECTOR AND METHOD
First Claim
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1. A method for detecting a target analyte in a sample, the method comprising:
- introducing magnetic particles comprising target-specific moieties to a sample comprising a plurality of target analytes under conditions such that at least one cluster of magnetic particles and target analytes is formed; and
using a nuclear magnetic resonance (NMR) device in order to measure a signal due to a change in relaxation rate, wherein the relaxation rate changes in the presence of the at least one cluster, thereby detecting the target analyte in the sample.
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Abstract
A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.
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Citations
10 Claims
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1. A method for detecting a target analyte in a sample, the method comprising:
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introducing magnetic particles comprising target-specific moieties to a sample comprising a plurality of target analytes under conditions such that at least one cluster of magnetic particles and target analytes is formed; and using a nuclear magnetic resonance (NMR) device in order to measure a signal due to a change in relaxation rate, wherein the relaxation rate changes in the presence of the at least one cluster, thereby detecting the target analyte in the sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification