HIGHLY GALACTOSYLATED ANTIBODIES
First Claim
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1. A composition, comprising:
- a population of antibodies wherein the population of antibodies is highly galactosylated.
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Abstract
In one aspect, the disclosure relates to antibodies that are highly galactosylated, methods of production of these antibodies and methods of use of these antibodies.
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Citations
74 Claims
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1. A composition, comprising:
a population of antibodies wherein the population of antibodies is highly galactosylated.
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2-6. -6. (canceled)
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7. A composition, comprising:
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a population of antibodies, wherein the level of galactosylation of the antibodies in the population is at least 70%, wherein the population of antibodies comprises antibodies that comprise mono-galactosylated N-glycans, and wherein antibodies in the population are encoded by the same nucleic acid sequence. - View Dependent Claims (8)
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9-11. -11. (canceled)
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12. A composition, comprising:
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a population of antibodies, wherein the ratio of the level of galactosylation of the antibodies in the population to the level of fucosylation of the antibodies in the population is between 0.8 and 1.2, wherein the population of antibodies comprises antibodies that comprise mono-galactosylated N-glycans, and wherein antibodies in the population are encoded by the same nucleic acid sequence. - View Dependent Claims (13, 15, 16, 21, 25, 32, 73, 74)
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14. (canceled)
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17-20. -20. (canceled)
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22-24. -24. (canceled)
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26-31. -31. (canceled)
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33-38. -38. (canceled)
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39. A method for producing a highly galactosylated population of antibodies, comprising:
producing the population of antibody in mammary gland epithelial cells such that a highly galactosylated population of antibodies is produced. - View Dependent Claims (40, 42, 47, 50, 53, 55, 56, 71)
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41. (canceled)
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43-46. -46. (canceled)
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48-49. -49. (canceled)
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51-52. -52. (canceled)
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54. (canceled)
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57-70. -70. (canceled)
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72. (canceled)
Specification