SPINAL CORD MODULATION FOR INDUCING PARESTHETIC AND ANESTHETIC EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS

• US 20140296936A1
• Filed: 05/30/2014
• Published: 10/02/2014
• Est. Priority Date: 04/22/2009
• Status: Active Grant

• Current Assignee: Nevro Corporation
• Original Assignee: Nevro Corporation
• Inventors: Alataris, Konstantinos, Walker, Andre B., Parker, Jon
• Granted Patent: US 10,493,275 B2
• Time in Patent Office: Days
• US Class Current: 607/46
• CPC Class Codes: A61N 1/06 for high-frequency therapy
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36132 using patient feedback
• CPC Class Codes: A61N 1/3615 Intensity
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36178 Burst or pulse train parameters

Abstract

Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods are disclosed. A representative method in accordance with an embodiment of the disclosure includes creating a therapeutic effect and a sensation in a patient by delivering to the patient first pulses having a first set of first signal delivery parameters and second pulses having a second set of second signal delivery parameters, wherein a first value of at least one first parameter of the first set is different than a second value of a corresponding second parameter of the second set, and wherein the first pulses, the second pulses or both the first and second pulses are delivered to the patient'"'"'s spinal cord.

Claims

1-60. -60. (canceled)

61. A system for treating patient pain, comprising:

an implantable signal delivery device having a plurality of electrodes configured to be implanted within a patient'"'"'s epidural space, proximate to one or more target neural populations in the patient'"'"'s spinal cord; and

a pulse generator having a controller programmed with instructions for;

generating and delivering to the signal delivery device bursts of first electrical pulses having a frequency in a first frequency range of from 1.5 kHz to 50 kHz, to create an anesthetic, non-paresthetic effect in the patient; and

generating and delivering to the signal delivery device second electrical pulses having a frequency in a second frequency range of from 2 Hz to 1.2 kHz to create a paresthetic effect in the patient, wherein the second electrical pulses include a single second pulse during an interval between sequential bursts of the first electrical pulses.

62. The system of claim 61 wherein the pulse generator includes instructions for directing the first electrical pulses to a first electrode of the signal delivery device and directing the second electrical pulses to a second electrode of the signal delivery device, wherein the second electrode is different from the first electrode.

63. The system of claim 61 wherein the pulse generator is programmed with instructions for directing the first and second electrical pulses sequentially to the same electrode of the signal delivery device.

64. The system of claim 61 wherein the first and second pulses have different pulse widths.

65. The system of claim 61 wherein the first electrical pulses have a first pulse width and wherein the second electrical pulses have a second pulse width, and wherein the second pulse width is greater than the first pulse width.

66. The system of claim 61 wherein the pulse generator further includes instructions for receiving first updates to first signal delivery parameters in accordance with which the first electrical pulses are delivered, and second, independent updates to second signal delivery parameters in accordance with which the second electrical pulses are delivered.

67. The system of claim 61 wherein the first frequency range is from 3 kHz to 10 kHz, and the second frequency range is from 20 Hz to 1.2 kHz.

68. The system of claim 61 wherein the first frequency range is from 3 kHz to 20 kHz.

69. The system of claim 61 wherein the first frequency range is from 3 kHz to 15 kHz.

70. The system of claim 61 wherein the first frequency range is from 5 kHz to 15 kHz.

71. The system of claim 61 wherein the first electrical pulses have an amplitude of from 0.1 mA to 20 mA.

72. The system of claim 61 wherein the first electrical pulses have an amplitude of from 0.5 mA to 10 mA.

73. The system of claim 61 wherein the first electrical pulses have an amplitude of from 0.5 mA to 4 mA.

74. The system of claim 61 wherein the first electrical pulses have pulse widths between 25 microseconds and 166 microseconds, inclusive.

75. The system of claim 61 wherein the first electrical pulses have pulse widths between 33 microseconds and 100 microseconds, inclusive.

76. The system of claim 61 wherein the second electrical pulses have an amplitude of from 2 mA to 10 mA.

77. The system of claim 61 wherein the second electrical pulses have pulse widths between 10 microseconds and 1,000 microseconds, inclusive.

78. A spinal cord stimulation system, comprising:

an implantable signal delivery device having at least one electrode configured to deliver one or more electrical therapy signals to one or more target neural populations in a patient'"'"'s spinal cord; and

a pulse generator configured to;

generate bursts of first electrical pulses having a frequency in a first frequency range of from 1.5 kHz to 100 kHz, to create an anesthetic, non-paresthetic effect in the patient; and

generate second electrical pulses having a frequency in a second frequency range of from 2 Hz to 1.2 kHz to create a paresthetic effect in the patient, wherein the second electrical pulses are delivered to the spinal cord during an interval between sequential bursts of the first electrical pulses.

79. The system of claim 78 wherein the pulse generator is an implantable pulse generator.

80. The system of claim 78 wherein the pulse generator is an external pulse generator.

81. The system of claim 78 wherein the pulse generator is configured to deliver the first pulses in accordance with a duty cycle.

82. The system of claim 78 wherein the implantable pulse generator further includes instructions for receiving first updates to first signal delivery parameters in accordance with which the first electrical pulses are delivered, and second, independent updates to second signal delivery parameters in accordance with which the second electrical pulses are delivered.

83. The system of claim 78 wherein the first frequency range is from 3 kHz to 20 kHz.

84. The system of claim 78 wherein the first frequency range is from 3 kHz to 15 kHz.

85. The system of claim 78 wherein the first frequency range is from 5 kHz to 15 kHz.

86. The system of claim 78 wherein the first electrical pulses have an amplitude of from 0.1 mA to 20 mA.

87. The system of claim 78 wherein the first electrical pulses have an amplitude of from 0.5 mA to 10 mA.

88. The system of claim 78 wherein the first electrical pulses have pulse widths between 25 microseconds and 166 microseconds, inclusive.

89. The system of claim 78 wherein the second electrical pulses have pulse widths from 10 microseconds to 1,000 microseconds, inclusive.