OPTIMIZED ANTI-CD3 VARIABLE REGIONS
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention is directed to optimized anti-CD3 variable sequences for use in a variety of bispecific formats, including those that utilize scFv components. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.
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Citations
47 Claims
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1-33. -33. (canceled)
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34. An anti-CD3 binding domain comprising a variable heavy sequence and a variable light sequence pair selected from the group consisting of SEQ ID NO:
- 5 and SEQ ID NO;
6;
SEQ ID NO;
9 and SEQ ID NO;
10;
SEQ ID NO;
13 and SEQ ID NO;
14;
SEQ ID NO;
17 and SEQ ID NO;
18;
SEQ ID NO;
21 and SEQ ID NO;
22;
SEQ ID NO;
25 and SEQ ID NO;
26;
SEQ ID NO;
29 and SEQ ID NO;
30;
SEQ ID NO;
33 and SEQ ID NO;
34;
SEQ ID NO;
37 and SEQ ID NO;
38;
SEQ ID NO;
41 and SEQ ID NO;
42;
SEQ ID NO;
45 and SEQ ID NO;
46;
SEQ ID NO;
49 and SEQ ID NO;
50;
SEQ ID NO;
53 and SEQ ID NO;
54;
SEQ ID NO;
57 and SEQ ID NO;
58;
SEQ ID NO;
61 and SEQ ID NO;
62;
SEQ ID NO;
65 and SEQ ID NO;
66;
SEQ ID NO;
69 and SEQ ID NO;
70;
SEQ ID NO;
73 and SEQ ID NO;
74;
SEQ ID NO;
77 and SEQ ID NO;
78;
SEQ ID NO;
81 and SEQ ID NO;
82;
SEQ ID NO;
85 and SEQ ID NO;
86;
SEQ ID NO;
89 and SEQ ID NO;
90;
SEQ ID NO;
93 and SEQ ID NO;
94;
SEQ ID NO;
97 and SEQ ID NO;
98;
SEQ ID NO;
101 and SEQ ID NO;
102;
SEQ ID NO;
105 and SEQ ID NO;
106;
SEQ ID NO;
109 and SEQ ID NO;
110;
SEQ ID NO;
113 and SEQ ID NO;
114;
SEQ ID NO;
117 and SEQ ID NO;
118;
SEQ ID NO;
121 and SEQ ID NO;
122;
SEQ ID NO;
125 and SEQ ID NO;
126;
SEQ ID NO;
129 and SEQ ID NO;
130;
SEQ ID NO;
133 and SEQ ID NO;
134;
SEQ ID NO;
137 and SEQ ID NO;
138;
SEQ ID NO;
141 and SEQ ID NO;
142;
SEQ ID NO;
145 and SEQ ID NO;
146;
SEQ ID NO;
149 and SEQ ID NO;
150;
SEQ ID NO;
153 and SEQ ID NO;
154;
SEQ ID NO;
157 and SEQ ID NO;
158;
SEQ ID NO;
161 and SEQ ID NO;
162;
SEQ ID NO;
165 and SEQ ID NO;
166;
SEQ ID NO;
169 and SEQ ID NO;
170;
SEQ ID NO;
173 and SEQ ID NO;
174;
SEQ ID NO;
177 and SEQ ID NO;
178;
SEQ ID NO;
181 and SEQ ID NO;
182;
SEQ ID NO;
185 and SEQ ID NO;
186;
SEQ ID NO;
189 and SEQ ID NO;
190;
SEQ ID NO;
193 and SEQ ID NO;
194;
SEQ ID NO;
197 and SEQ ID NO;
198;
SEQ ID NO;
201 and SEQ ID NO;
202;
SEQ ID NO;
205 and SEQ ID NO;
206;
SEQ ID NO;
209 and SEQ ID NO;
210;
SEQ ID NO;
213 and SEQ ID NO;
214;
SEQ ID NO;
217 and SEQ ID NO;
218;
SEQ ID NO;
221 and SEQ ID NO;
222;
SEQ ID NO;
225 and SEQ ID NO;
226;
SEQ ID NO;
229 and SEQ ID NO;
230;
SEQ ID NO;
233 and SEQ ID NO;
234;
SEQ ID NO;
237 and SEQ ID NO;
238;
SEQ ID NO;
241 and SEQ ID NO;
242;
SEQ ID NO;
245 and SEQ ID NO;
246;
SEQ ID NO;
249 and SEQ ID NO;
250;
SEQ ID NO;
253 and SEQ ID NO;
254;
SEQ ID NO;
257 and SEQ ID NO;
258;
SEQ ID NO;
261 and SEQ ID NO;
262;
SEQ ID NO;
265 and SEQ ID NO;
266;
SEQ ID NO;
269 and SEQ ID NO;
270;
SEQ ID NO;
273 and SEQ ID NO;
274;
SEQ ID NO;
277 and SEQ ID NO;
278;
SEQ ID NO;
281 and SEQ ID NO;
282;
SEQ ID NO;
285 and SEQ ID NO;
286;
SEQ ID NO;
289 and SEQ ID NO;
290;
SEQ ID NO;
293 and SEQ ID NO;
294;
SEQ ID NO;
297 and SEQ ID NO;
298;
SEQ ID NO;
301 and SEQ ID NO;
302;
SEQ ID NO;
305 and SEQ ID NO;
306;
SEQ ID NO;
309 and SEQ ID NO;
310;
SEQ ID NO;
313 and SEQ ID NO;
314;
SEQ ID NO;
317 and SEQ ID NO;
318;
SEQ ID NO;
321 and SEQ ID NO;
322;
SEQ ID NO;
325 and SEQ ID NO;
326;
SEQ ID NO;
329 and SEQ ID NO;
330;
SEQ ID NO;
333 and SEQ ID NO;
334;
SEQ ID NO;
337 and SEQ ID NO;
338;
SEQ ID NO;
341 and SEQ ID NO;
342;
SEQ ID NO;
345 and SEQ ID NO;
346;
SEQ ID NO;
349 and SEQ ID NO;
350;
SEQ ID NO;
353 and SEQ ID NO;
354;
SEQ ID NO;
357 and SEQ ID NO;
358;
SEQ ID NO;
361 and SEQ ID NO;
362;
SEQ ID NO;
365 and SEQ ID NO;
366;
SEQ ID NO;
369 and SEQ ID NO;
370;
SEQ ID NO;
373 and SEQ ID NO;
374;
SEQ ID NO;
377 and SEQ ID NO;
378;
SEQ ID NO;
381 and SEQ ID NO;
382;
SEQ ID NO;
385 and SEQ ID NO;
386;
SEQ ID NO;
389 and SEQ ID NO;
390;
SEQ ID NO;
393 and SEQ ID NO;
394;
SEQ ID NO;
397 and SEQ ID NO;
398;
SEQ ID NO;
401 and SEQ ID NO;
402;
SEQ ID NO;
405 and SEQ ID NO;
406; and
SEQ ID NO;
409 and SEQ ID NO;
410;
- View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
- 5 and SEQ ID NO;
Specification