METHODS OF DETERMINING A TREATMENT PROTOCOL FOR AND/OR A PROGNOSIS OF A PATIENT'S RECOVERY FROM A BRAIN INJURY
First Claim
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1. A method for determining a measure of the concentration of tau protein in a patient sample containing or suspected of containing tau protein, comprising:
- performing an assay to determine a measure of the concentration of tau protein in the sample, wherein the limit of detection of tau protein of the assay is less than about 0.2 pg/mL.
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Abstract
The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient'"'"'s recovery from a brain injury. In some embodiments, the brain injury results from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of tau protein in a patient sample containing or suspected of containing tau protein.
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Citations
56 Claims
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1. A method for determining a measure of the concentration of tau protein in a patient sample containing or suspected of containing tau protein, comprising:
performing an assay to determine a measure of the concentration of tau protein in the sample, wherein the limit of detection of tau protein of the assay is less than about 0.2 pg/mL. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of determining a treatment protocol for and/or a prognosis of a patient'"'"'s recovery from a brain injury comprising:
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performing an assay on a blood sample from the patient and/or plasma and/or serum derived from the blood sample to determine a measure of the concentration of tau protein in the sample; and determining a prognosis of the patient'"'"'s recovery from the brain injury and/or a method of treatment based at least in part on the measured concentration of tau protein present in the sample. - View Dependent Claims (13, 20, 21, 22, 23, 24, 25)
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14-19. -19. (canceled)
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26-54. -54. (canceled)
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55. A method of determining a method of treatment for and/or a prognosis of a patient'"'"'s recovery from a brain injury, comprising:
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(a) performing an assay on each of a plurality of samples obtained from the patient following the brain injury to determine the measured concentration of tau protein in each of the samples, wherein the plurality of samples are obtained from the patient over a period of time of at least about 48 hours; (b) determining the area under the curve of a graph of the tau protein concentration in the plurality of samples versus time, wherein the area is determined for the entire time period and/or for a second peak in the tau protein concentration; and (c) determining a prognosis of the patient'"'"'s recovery from the brain injury and/or a method of treatment based at least in part on the area under the curve for the entire time period and/or the second peak in the tau protein concentration determined in step (b).
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56-91. -91. (canceled)
Specification