Tissue Disorder Imaging Analysis
First Claim
Patent Images
1. A non-patient specific hazard atlas of a disorder in a patient tissue comprising an image of the patient'"'"'s tissue, wherein the image comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of the patient tissue at that location such that the hazard value contains location specific information about the impact that the voxel'"'"'s death would have on behavior.
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Abstract
Methods and systems are described for quantitatively determining a score for a patient having a disorder, e.g. a stroke, in a tissue, such as the brain, by analyzing both the extent and location of damage to the tissue caused by the disorder.
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Citations
28 Claims
- 1. A non-patient specific hazard atlas of a disorder in a patient tissue comprising an image of the patient'"'"'s tissue, wherein the image comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of the patient tissue at that location such that the hazard value contains location specific information about the impact that the voxel'"'"'s death would have on behavior.
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20. A method for determining a patient'"'"'s hazard score for a disorder in a patient tissue, the method comprising:
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obtaining an image of a tissue of the patient, wherein the image comprises a plurality of patient image voxels; identifying voxels of the patient image that are damaged by the disorder as damaged patient image voxels; obtaining a non-patient specific hazard atlas of the disorder in a tissue;
wherein the hazard atlas comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of the tissue at that location such that the hazard value contains location specific information about the impact that the voxel'"'"'s death would have on behavior; andcomputing a hazard score for the patient, wherein the hazard score is the integration of all damaged patient image voxels weighted by the hazard value corresponding to that voxel location;
wherein the hazard score determines the patient'"'"'s prognosis. - View Dependent Claims (21, 22, 23, 24, 25)
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26. A method of generating an expert hazard atlas, the method comprising:
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identifying one or more of anatomical, vascular, and functional regions on a standard set of anatomical images of a tissue; assigning weighting factors to the regions according to clinically-relevant assessment methodologies; and generating a non-patient specific expert hazard atlas of the tissue comprising a plurality of voxels based on the weighting factors for each voxel in the atlas.
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27. A method of generating a data-driven non-patient specific hazard atlas, the method comprising:
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acquiring patient image data; matching patient image data to a standardized set of anatomical images; identifying regions of the patient'"'"'s tissue with damage based on the image data; assigning weighting factors to the regions based on actual patient outcome data; and generating a data-driven non-patient specific hazard atlas of the tissue comprising a plurality of voxels based on the weighting factors for each voxel in the atlas.
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28. A computer program for determining a hazard score of a patient having a disorder in a patient tissue, the program residing on a computer-readable medium and comprising instructions for causing a processor to:
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(a) obtain an image of a tissue of the patient, wherein the image comprises a plurality of patient image voxels; (b) identify voxels of the patient image that are damaged by the disorder as damaged patient image voxels; (c) obtain from a memory or computer-readable medium a non-patient specific hazard atlas of the disorder in a tissue, wherein the hazard atlas comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of the tissue at that location such that the hazard value contains location specific information about the impact that the voxel'"'"'s death would have on behavior; (d) compute a hazard score for the patient, wherein the hazard score is the integration of all damaged patient image voxels weighted by the hazard value corresponding to that voxel location;
wherein the hazard score determines the patient'"'"'s prognosis; and(e) transmit the hazard score to an output device.
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Specification