METHOD AND APPARATUS FOR THE ASSESSMENT OF MEDICAL IMAGES
First Claim
1. A method of determining the degree of uptake of a PET maker in an individual candidate PET scan, the method of including the steps of:
- (a) calculating a series of representative matched controlled PET and MRI templates for a series of controlled sample scans of individuals;
(b) computing a series of brain surfaces from the matched templates;
(c) aligning the individual candidate PET scan with the candidate templates;
(d) aligning the series of brain surfaces with the candidate PET images;
(e) selecting a predetermined (M) best candidate templates for each surface location based on a similarity measure between the candidate PET values and the corresponding controlled PET scans;
(f) computing M weights for each surface location, utilizing a corresponding MRI tissue map;
(g) utilizing the M weights to combine a corresponding M template tissue indicators from corresponding MRI templates into an average brain surface indicator.
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Abstract
A method of determining the degree of uptake of a PET maker in an individual candidate PET scan, the method including the steps of: (a) calculating a series of representative matched controlled PET and MRI templates for a series of controlled sample scans of individuals; (b) computing a series of brain surfaces from the matched templates; (c) aligning the individual candidate PET scan with the candidate templates; (d) aligning the candidate PET images with the series of brain surfaces; (e) selecting a predetermined (M) best candidate templates for each surface location based on a similarity measure between the candidate PET values and the corresponding controlled PET scans; (f) computing M weights for each surface location, utilizing a corresponding MRI tissue map; (g) utilizing the M weights to combine a corresponding M template tissue indicators from corresponding MRI templates into an average brain surface indicator.
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Citations
17 Claims
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1. A method of determining the degree of uptake of a PET maker in an individual candidate PET scan, the method of including the steps of:
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(a) calculating a series of representative matched controlled PET and MRI templates for a series of controlled sample scans of individuals; (b) computing a series of brain surfaces from the matched templates; (c) aligning the individual candidate PET scan with the candidate templates; (d) aligning the series of brain surfaces with the candidate PET images; (e) selecting a predetermined (M) best candidate templates for each surface location based on a similarity measure between the candidate PET values and the corresponding controlled PET scans; (f) computing M weights for each surface location, utilizing a corresponding MRI tissue map; (g) utilizing the M weights to combine a corresponding M template tissue indicators from corresponding MRI templates into an average brain surface indicator. - View Dependent Claims (2, 3, 8, 15, 16, 17)
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4. A method of determining the degree of uptake of an imaging marker in an individual candidate imaging marker scan, the method including the steps of:
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(a) calculating a series of representative matched controlled imaging marker scans and tissue marker templates for a series of controlled sample scans of individuals; (b) computing a series of internal body delineation surfaces from the matched templates; (c) aligning the individual candidate imaging marker scan with the candidate templates; (d) aligning the individual candidate imaging marker scan with the series of body delineation surfaces; (e) selecting a predetermined (M) best candidate templates for each surface location based on a similarity measure between the candidate imaging marker values and the corresponding controlled imaging marker scans; (f) computing M weights for each surface location, utilizing a corresponding tissue marker map; (g) utilizing the M weights to combine a corresponding M template tissue indicators from corresponding tissue templates into an average brain surface indicator. - View Dependent Claims (5, 6, 7)
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9. A method of determining the brain uptake if an imaging marker in a subject image, the method including the steps of:
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preparing a series of brain templates from controlled sample images, the templates including coregistering a series of controlled sample images, and creating a probability map containing an approximation of the likelihood that a particular atlas voxel contains grey matter; determining from the brain templates, a correspondence surface between grey and white matter interfaces; for the candidate subject image, mapping the candidate image to a corresponding brain template; and mapping the correspondence in grey matter uptake for the subject image for grey area portions of the brain templates. - View Dependent Claims (10, 11, 12, 13, 14)
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Specification