Organs for Transplantation

• US 20140308252A1
• Filed: 04/14/2014
• Published: 10/16/2014
• Est. Priority Date: 04/12/2013
• Status: Active Grant

• Current Assignee: Houston Methodist Hospital (Methodist Hospital)
• Original Assignee: ABT Holding Company (Athersys, Inc.)
• Inventors: LaFrancesca, Saverio, Ting, Anthony P., Deans, Robert J.
• Granted Patent: US 9,861,660 B2
• Time in Patent Office: Days
• US Class Current: 424/93.7
• CPC Class Codes: A61K 35/12 Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells vaccines or medicinal preparations containing antigens or antibodies A61K39/00
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 1/18 for pancreatic disorders, e.g. pancreatic enzymes
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: C12N 2500/84 from mammals
• CPC Class Codes: C12N 2502/03 non-embryonic pluripotent stem cells
• CPC Class Codes: C12N 5/0018 Culture media for cell or tissue culture media for specific animal cell type C12N5/06
• CPC Class Codes: C12N 5/0607 Non-embryonic pluripotent stem cells, e.g. MASC induced pluripotent stem cells C12N5/0696

Abstract

The invention provides methods and compositions that improve the success of organ transplantation. The methods and compositions are directed to exposing a desired organ to stem cells prior to, during, and/or after transplantation. In one embodiment, the stem cells reduce the deleterious effects of ischemia on an organ designated to be harvested for transplantation or that has been harvested for transplantation. In another embodiment in which an organ designated for transplantation is perfused ex vivo, the method involves reducing ischemic reperfusion injury by perfusing the organ with a medium that contains stem cells.

Claims

1. A system comprising:

a database configured to associate a particular wireless device with at least one geographic area;

a speed determiner configured to determine a change in location over time of the particular wireless device relative to the at least one geographic area; and

an area watcher to selectively output a trigger message from a plurality of trigger messages for the a geographic area, the trigger message being selected from the plurality of trigger messages based on the determined change in location over time of the particular wireless device upon the particular wireless device one or more of entering and exiting the geographic area.

2. The subscriber feature for a wireless system according to claim 1, wherein the geographic area is defined by a zip code.

3. The subscriber feature for a wireless system according to claim 1, wherein the geographic area is defined by boundaries of the reach of a particular cell site.

4. The subscriber feature for a wireless system according to claim 1, wherein the geographic area is defined by proximity to a particular retail establishment.

5. A method comprising:

establishing a watched geographic area;

monitoring location information of a plurality of wireless devices;

monitoring a change in location over time of a given wireless device of the plurality of wireless devices relative to the watched geographic area;

selecting an area watch message from the plurality of area watch messages based on the monitored change in location over time of the wireless device upon detection of the given wireless device at least one of entering and exiting the watched geographic area; and

providing the selected watch message to the given wireless device.

6. The method of claim 5, wherein the selected area watch message corresponds to unsolicited retail information.

7. The method of claim 5, further comprising associating the given wireless device with the watched geographic area.

8. The method of claim 5, wherein the monitoring comprises polling of location information for the plurality of wireless devices.

9. The method of claim 5, wherein the monitoring comprises a location push by the given wireless device.

10. The method of claim 5, wherein the monitoring comprises a location push by a wireless carrier network servicing the given wireless device.

11. A system comprising:

means for establishing a watched geographic area;

means for monitoring location information regarding a wireless device;

means for monitoring a change in location over time of the wireless device relative to the at least one geographic area; and

means for selectively triggering a selected area watch message of a plurality of area watch messages for the geographic area, the selected area watch message being selected from the plurality of area watch messages based on the monitored change in location over time of the wireless device upon detection of the wireless device at least one of entering and exiting the watched geographic area.

12. The system of claim 11, wherein the selected area watch message corresponds to unsolicited retail information.

13. The system of claim 11, further comprising means for associating the given wireless device with the watched geographic area.

14. The system of claim 11, wherein the means for monitoring polls location information regarding the wireless device.

15. The system of claim 11, wherein the monitoring comprises a location push from the wireless device.

16. The system of claim 11, wherein the monitoring comprises a location push from a wireless carrier network servicing the wireless device.