SYSTEMS AND METHODS FOR MULTI-ANALYSIS
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Accused Products
Abstract
Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
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Citations
28 Claims
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1-8. -8. (canceled)
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9. A biological sample processing device containing therein:
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an automated sample handling system; a first detection station comprising an optical sensor; a second detection station comprising a light source and an optical sensor; a cytometry station comprising an imaging device and a stage for receiving a microscopy cuvette; and a cartridge, wherein the cartridge is insertable into and removable from the biological sample processing device, and wherein the cartridge supports i) a biological sample, ii) at least a first, a second, and a third fluidically isolated assay unit, and iii) reagents to perform A) at least one luminescence assay;
B) at least one absorbance, turbimetric, fluorescence, or colorimetric assay; and
C) at least one cytometry assay, wherein the first assay unit is configured to perform a luminescence assay, the second assay unit is configured to perform an absorbance, turbidimetric, fluorescence, or colorimetric assay, the third assay unit is configured to perform a cytometry assay, and wherein the automated sample handling system is configured to i) transfer at least a portion of the biological sample to each of the first, second, and third assay units;
ii) transfer the first assay unit containing biological sample to the first detection station;
iii) transfer the second assay unit containing biological sample to the second detection station; and
iv) transfer the third assay unit containing biological sample to the cytometry station. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for performing multiple assays with a biological sample, the method comprising:
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providing a biological sample processing device containing therein; an automated sample handling system; a first detection station comprising an optical sensor; a second detection station comprising a light source and an optical sensor; a cytometry station comprising an imaging device and a stage for receiving a microscopy cuvette; and a cartridge, wherein the cartridge is insertable into and removable from the biological sample processing device, and wherein the cartridge supports i) a biological sample, ii) at least a first, a second, and a third fluidically isolated assay unit, and iii) reagents to perform A) at least one luminescence assay;
B) at least one absorbance, turbimetric, fluorescence, or colorimetric assay; and
C) at least one cytometry assay, and wherein the first assay unit is configured to perform a luminescence assay, the second assay unit is configured to perform an absorbance, turbidimetric, fluorescence, or colorimetric assay, the third assay unit is configured to perform a cytometry assay, andtransferring by the automated sample handling system at least a portion of the biological sample to each of the first, second, and third assay units; transferring by the automated sample handling system the first assay unit containing biological sample to the first detection station; transferring by the automated sample handling system the second assay unit containing biological sample to the second detection station; and transferring by the automated sample handling system the third assay unit containing biological sample to the cytometry station. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28)
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Specification