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Encoded Nanopore Sensor for Multiplex Nucleic Acids Detection

  • US 20140309129A1
  • Filed: 03/14/2014
  • Published: 10/16/2014
  • Est. Priority Date: 03/15/2013
  • Status: Active Grant
First Claim
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1. A set of probe molecules comprising at least a first probe molecule and a second probe molecule, wherein at least two probe molecules comprise:

  • a) a capture domain that comprises a sequence with complementarity to a target nucleic acid;

    b) a terminal extension that is covalently linked to the 5′

    end, the 3′

    end, or both the 5′

    end and the 3′

    end of the capture domain; and

    c) at least one polymer label attached to at least one of the terminal extension(s),wherein the nucleic acid capture domain of the first probe molecule comprises a sequence with complementarity to first target nucleic acid and the nucleic acid capture domain of the second probe molecule comprises a sequence with complementarity to a second target nucleic acid,and wherein the polymer label of the first probe molecule is different from the polymer label of the second probe molecule and provide for independent detection of the first and second target nucleic acids in a nanopore system.

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