FURANYL COMPOUNDS AND THE USE THEREOF
1 Assignment
0 Petitions
Accused Products
Abstract
Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
3 Citations
37 Claims
-
1-19. -19. (canceled)
- 20. A method of treating, preventing, or ameliorating one or more symptoms of a disorder mediated by the Hedgehog pathway in a subject, comprising administering to the subject a compound of Formula (I):
-
31. A method of treating, preventing, or ameliorating one or more symptoms of a disorder mediated by cap-dependent protein translation in a subject, comprising administering to the subject a compound of Formula (I):
-
32. A method of treating, preventing, or ameliorating one or more symptoms of a disorder mediated by eIF4E in a subject, comprising administering to the subject a compound of Formula (I):
- 33. A compound of Formula (I):
Specification