LIQUID DOSAGE FORM AND DELIVERY SYSTEM

• US 20140311929A1
• Filed: 04/17/2014
• Published: 10/23/2014
• Est. Priority Date: 04/18/2013
• Status: Active Application

• Current Assignee: Stephen Tickle
• Original Assignee: NuPharm Laboratories Limited (Clinigen Group PLC)
• Inventors: Tickle, Stephen, Gould, William Michael
• Application Number:
  US14/255,915
• Publication Number:
  US 20140311929A1
• Time in Patent Office: Days
• US Class Current: 206/219
• CPC Class Codes: A61J 1/00 Containers specially adapted for medical or pharmaceutical purposes capsules or the like for oral use A61J3/07; specially adapted for surgical or diagnostic appliances or instruments A61B50/30; containers for radioactive substances G21F5/00
• CPC Class Codes: A61K 31/4439 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole nicotine A61K31/465
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 9/10 Dispersions; Emulsions A61K9/06 takes precedence; composition of dispersions, emulsions A61K47/00
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

A pharmaceutical dosage form comprising solid liquid components comprising solid and liquid components; the solid component comprising omeprazole as active ingredient; one or more water soluble excipients; wherein the liquid component comprises: a surfactant; water and optional further excipients.

Claims

1. A pharmaceutical dosage form comprising solid liquid components comprising a solid component and a liquid component;

the solid component comprising omeprazole as active ingredient;

one or more water soluble excipients;

wherein the liquid component comprises;

a surfactant;

water and optional further excipients.

2. The pharmaceutical dosage form as claimed in claim 1, wherein the water soluble excipient is a sweetener.

3. The pharmaceutical dosage form as claimed in claim 2, wherein the water soluble excipient is selected from the group consisting of isomalt, dextrose, lactose, maltose, maltitol, sucrose, xylitol, and mixtures thereof.

4. The pharmaceutical dosage form as claimed in claim 3 wherein the water soluble excipient is isomalt.

5. The pharmaceutical dosage form as claimed in claim 4, wherein the solid component comprises:

omeprazole 7.5%-30%; and

isomalt 70%-92.5%.

6. The pharmaceutical dosage form as claimed in claim 1, wherein the surfactant is polysorbate 80.

7. A delivery system for a dosage form comprising solid liquid components comprising a solid component and a liquid component, the delivery system comprising:

a container having a volumetric capacity to receive the liquid component; and

a closure, adapted to releasably close the container,

the closure including a receptacle for the solid component, and release means arranged when actuated to release the solid component into the container without opening the container.

8. The delivery system as claimed in claim 7 wherein the receptacle includes a frangible wall located between the capsule and the interior of the container, and means for rupturing the wall to open the receptacle and release the solid component into the container.