SYSTEMS AND METHODS FOR MONITORING BRAIN METABOLISM AND ACTIVITY USING ELECTROENCEPHALOGRAM AND OPTICAL IMAGING

• US 20140316218A1
• Filed: 04/23/2014
• Published: 10/23/2014
• Est. Priority Date: 04/23/2013
• Status: Abandoned Application

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Purdon, Patrick L., Brown, Emery N., Boas, David A., Franceschini, Maria Angela, Ching, ShiNung, Sutin, Jason
• Application Number:
  US14/260,070
• Publication Number:
  US 20140316218A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 5/0036 including treatment, e.g., using an implantable medical device, ablating, ventilating
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/4866 Evaluating metabolism A61B5/083 takes precedence
• CPC Class Codes: A61B 5/7235 Details of waveform analysis A61B5/349 takes precedence

Abstract

Systems and methods for monitoring and/or controlling a brain state of a subject are provided. In certain embodiments, the method includes acquiring physiological data from sensors including electrophysiological sensors and optical sensors, assembling, using data from the electrophysiological sensors, a time-series signal indicative of a brain activity of the subject, and identifying, using the time-series signal, a burst suppression state described by a burst suppression period and a burst period. The method also includes computing, using data from the optical sensors, parameters associated with the burst suppression state, the parameters indicative of least one of a metabolic process and a hemodynamic process, and estimating, using the parameters, time-series signal, and burst period, a response function describing a time course of the parameters correlated with a burst during the burst suppression period. The method further includes controlling a treatment using the response function to generate a target burst suppression state.

Claims

1. A system for monitoring and controlling a state of a subject, the system comprising:

an input configured to receive physiological data from a plurality of sensors coupled to the subject, the plurality of sensors including electrophysiological sensors and optical sensors;

at least one optical source configured to direct light in a range of wavelengths to at least one portion of a subject'"'"'s anatomy;

at least one processor configured to;

acquire the physiological data from the plurality of sensors positioned on a subject;

assemble, using the physiological data from the electrophysiological sensors, a time-series signal indicative of a brain activity of the subject;

identify, using the time-series signal, a burst suppression state described by a burst suppression period and a burst period;

compute, using the physiological data from the optical sensors, parameters associated with the burst suppression state, the parameters indicative of least one of a metabolic process and a hemodynamic process;

estimate, using the parameters, time-series signal, and burst period, a response function describing a time course of the parameters correlated with a burst during the burst suppression period; and

generate a report indicative of the response function.

2. The system of claim 1, wherein the range of wavelengths includes a near-infrared range between 650 and 950 nanometers.

3. The system of claim 1, wherein the at least one optical source is configured to probe at least one of a static property and a dynamic property of biological tissue within at least one portion of the a subject'"'"'s anatomy, wherein the static property includes a tissue absorption and a tissue scattering, and the dynamic property includes a motion of scatterers.

4. The system of claim 1, wherein the system is further configured to acquire the physiological data using at least one of a frequency domain near infra-red spectroscopy (“

FD-N IRS”

) technique, a continuous-wave near-infrared spectroscopy (“

CW-NIRS”

) technique, and diffusion correlation spectroscopy (“

DCS”

) technique.

5. The system of claim 1, wherein the at least one processor is further configured to compute at least one of an oxy-hemoglobin (“

HbO”

) parameter, a deoxyhemoglobin (“

HbR”

) parameter, a cerebral blood flow (“

CBF”

) parameter, an oxygen extraction (SO₂) parameter, an oxygen fraction (“

OEF”

) parameter, a cerebral flow volume (“

CFV”

) parameter, a cerebral metabolic rate of oxygen (“

CMRO₂”

) parameter, a flow-volume parameter, and a flow-metabolism coupling ratio parameter.

6. The system of claim 1, wherein the at least one processor is further configured to correlate the response function with a brain state of the subject and wherein the report indicates the brain state of the subject.

7. The system of claim 6, wherein the brain state of the subject is defined by at least one of a metabolic characteristic and a hemodynamic characteristic.

8. The system of claim 6, wherein the at least one processor is further configured to generate a target burst suppression state using the state, the response function and an indication received from the input, the indication including at least one of a patient characteristic, an anesthetic dose, an anesthetic administration time, an anesthetic infusion rate, a temperature, and a temperature rate.

9. The system of claim 1, wherein the at least one processor is further configured to control an administration of a treatment to achieve the generated target burst suppression state.

10. The system of claim 9, wherein the treatment includes one of a hypothermia treatment and an anesthesia treatment.

11. A method for monitoring a brain state of a subject, the method comprising:

acquiring physiological data from a plurality of sensors positioned on the subject, the plurality of sensors including electrophysiological sensors and optical sensors;

assembling, using the physiological data from the electrophysiological sensors, a time-series signal indicative of a brain activity of the subject;

identifying, using the time-series signal, a burst suppression state described by a burst suppression period and a burst period;

computing, using the physiological data from the optical sensors, parameters associated with the burst suppression state, the parameters indicative of least one of a metabolic process and a hemodynamic process;

estimating, using the parameters, time-series signal, and burst period, a response function describing a time course of the parameters correlated with a burst during the burst suppression period; and

generating a report indicative of the response function.

12. The method of claim 11, wherein the range of wavelengths includes a near-infrared range between 650 and 950 nanometers.

13. The method of claim 11, wherein method further comprises acquiring physiological data using at least one of a frequency domain near infra-red spectroscopy (“

FD-N IRS”

) technique, a continuous-wave near-infrared spectroscopy (“

CW-NIRS”

) technique, and diffusion correlation spectroscopy (“

DCS”

) technique.

14. The method of claim 11, wherein the method further includes computing at least one of an oxy-hemoglobin (“

HbO”

) parameter, a deoxyhemoglobin (“

HbR”

) parameter, a cerebral blood flow (“

CBF”

) parameter, an oxygen extraction (SO₂) parameter, an oxygen fraction (“

OEF”

) parameter, a cerebral flow volume (“

CFV”

) parameter, a cerebral metabolic rate of oxygen (“

CMRO₂”

) parameter, a flow-volume parameter, and a flow-metabolism coupling ratio parameter.

15. The method of claim 11, wherein the method further comprises correlating the response function with a brain state of the subject and wherein the report indicates the brain state of the subject.

16. The method of claim 15, wherein the brain state of the subject is defined by at least one of a metabolic characteristic and a hemodynamic characteristic.

17. The method of claim 15, wherein method further comprises generating a target burst suppression state using the state, the response function and an indication received from the input, the indication including at least one of a patient characteristic, an anesthetic dose, an anesthetic administration time, an anesthetic infusion rate, a temperature, and a temperature rate.

18. The method of claim 11, wherein the method further comprises controlling an administration of a treatment to achieve the target burst suppression state.

19. The method of claim 18, wherein the treatment includes one of a hypothermia treatment and an anesthesia treatment.

27. The method of claim 15, wherein controlling the administration of the treatment includes receiving an indication from an input that includes at least one of a patient characteristic, an anesthetic dose, an anesthetic administration time, an anesthetic infusion rate, a temperature, and a temperature rate.

20. A method for monitoring and controlling a brain state of a subject, the method comprising:

acquiring physiological data from a plurality of sensors positioned on the subject, the plurality of sensors including electrophysiological sensors and optical sensors;

assembling, using the physiological data from the electrophysiological sensors, a time-series signal indicative of a brain activity of the subject;

identifying, using the time-series signal, a burst suppression state described by a burst suppression period and a burst period;

computing, using the physiological data from the optical sensors, parameters associated with the burst suppression state, the parameters indicative of least one of a metabolic process and a hemodynamic process;

estimating, using the parameters, time-series signal, and burst period, a response function describing a time course of the parameters correlated with a burst during the burst suppression period; and

controlling an administration of a treatment using the response function to achieve a target burst suppression state.

21. The method of claim 20, wherein the range of wavelengths includes a near-infrared range between 650 and 950 nanometers.

22. The method of claim 20, wherein method further comprises acquiring physiological data using at least one of a frequency domain near infra-red spectroscopy (“

FD-N IRS”

) technique, a continuous-wave near-infrared spectroscopy (“

CW-NIRS”

) technique, and diffusion correlation spectroscopy (“

DCS”

) technique.

23. The method of claim 20, wherein the method further includes computing at least one of an oxy-hemoglobin (“

HbO”

) parameter, a deoxyhemoglobin (“

HbR”

) parameter, a cerebral blood flow (“

CBF”

) parameter, an oxygen extraction (SO₂) parameter, an oxygen fraction (“

OEF”

) parameter, a cerebral flow volume (“

CFV”

) parameter, a cerebral metabolic rate of oxygen (“

CMRO₂”

) parameter, a flow-volume parameter, and a flow-metabolism coupling ratio parameter.

24. The method of claim 20, wherein the method further comprises correlating the response function with a brain state of the subject.

25. The method of claim 24, wherein the method further comprises generating a report indicative of the brain state of the subject

26. The method of claim 24, wherein the brain state of the subject is defined by at least one of a metabolic characteristic and a hemodynamic characteristic.

28. The method of claim 20, wherein the treatment includes one of a hypothermia treatment and an anesthesia treatment.