Foam-Based Medical Treatments

• US 20140316367A1
• Filed: 03/17/2014
• Published: 10/23/2014
• Est. Priority Date: 11/01/2011
• Status: Active Grant

• Current Assignee: Arsenal Medical, Inc
• Original Assignee: Meghan McGill
• Inventors: Zugates, Gregory T., Rago, Adam, Freyman, Toby, Sharma, Upma, Busold, Rany, Zamiri, Parisa, Mortensen, Jennifer, McGill, Meghan, Caulkins, John, Bonner, Daniel K.
• Granted Patent: US 9,623,143 B2
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61L 2300/418 Agents promoting blood coagulation, blood-clotting agents, embolising agents
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 2430/22 for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus
• CPC Class Codes: A61L 27/14 Macromolecular materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61P 7/04 Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

The present invention relates generally to systems and methods and systems for generating polymer foams within body cavities to locate and/or control bleeding. The present invention further relates to methods and systems for generating polymer foams within non-compressible wounds to control or stop bleeding. The present invention further relates to the use of foams and gels for medical and cosmetic purposes.

Claims

1. A method of treating a patient, comprising:

providing a structure comprising a first and second bag, wherein said second bag at least partially covers said first bag, the first and second bags being attached to each other,

inserting said structure into a cavity within the patient,

inserting a polymer into said first bag after said structure is inserted into said cavity, and

forming a foam from said polymer after said polymer is inserted into said first bag.

2. The method of claim 1, wherein said method is used to treat an intestinal hemorrhage.

3. The method of claim 1, wherein said method is used to treat a junctional hemorrhage.

4. The method of claim 1, wherein said method is used to treat a sinus hemorrhage.

5. The method of claim 1, wherein said foam expands within said structure to exert pressure on a wall of said cavity.

6. The method of claim 1, wherein said first and second bags each comprise a plurality of pores.

7. The method of claim 6, wherein at least of portion of said foam extends through at least some of the pores of said first and second bags.

8. The method of claim 1, wherein said foam comprises a compound that promotes blood clotting.

9. The method of claim 1, further comprising the step of removing said structure from the patient by applying tension to the first bag.

10. The method of claim 1, wherein said polymer comprises polyurethane.

11. The method of claim 10, wherein said polymer further comprises an isocyanate compound selected from the group consisting of hexamethylene diisocyanate, toluene diisocyanate, methylene diphenyl diisocyanate, and isophorone diisocyanate.

13. The method of claim 1, further comprising the step of introducing a gas into at least one of said first bag and said second bag after said step of forming said form.

14. The method of claim 1, wherein at least one of said first bag and said second bag comprises multiple sections that are retained in proximity to one another using an attachment means.

15. The method of claim 1, wherein said first and second bags are attached to one another at a distal end of each of said first and second bags.

12. The method of claim 12, further comprising a hydroxyl-functionalized polymer.

16. A method of treating a hemorrhage, comprising:

providing a structure comprising a first and second bag, said first bag comprising a plurality of pre-formed foam components, wherein said second bag at least partially covers said first bag, the first and second bags being attached to each other, and

inserting said structure at the site of a hemorrhage.

17. The method of claim 16, wherein said hemorrhage is an intestinal hemorrhage.

18. The method of claim 16, wherein said hemorrhage is a junctional hemorrhage.

19. The method of claim 16, wherein said hemorrhage is within an organ.

20. The method of claim 16, further comprising the step of removing said structure from said patient by applying tension to said first bag.

21. The method of claim 16, wherein said pre-formed foam components are attached end-to-end.