METHODS FOR THE ELECTROCHEMICAL TREATMENT OF SELF-ASSEMBLED MONOLAYERS
First Claim
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1. A method for detecting the presence of a target analyte in a sample, the method comprising:
- a) providing an electrode comprising a monolayer and a capture binding ligand;
b) initializing the electrode;
c) hybridizing a probe to said target analyte to form an assay complex; and
d) detecting the presence or absence of said target analyte.
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Abstract
The present invention provides compositions and methods directed to an electrode initialization step for the electrochemical treatment of monolayers used in electrochemical detection of target analytes on the surface of a monolayer. Electrode initialization creates a more stable monolayer, and resolves variability within the electrochemical signal detected on the monolayer.
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Citations
18 Claims
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1. A method for detecting the presence of a target analyte in a sample, the method comprising:
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a) providing an electrode comprising a monolayer and a capture binding ligand; b) initializing the electrode; c) hybridizing a probe to said target analyte to form an assay complex; and d) detecting the presence or absence of said target analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification