MULTI-PARAMETER TEST UNITS FOR INITIAL INDICATION OF MEDICAL SYMPTOMS

• US 20140323819A1
• Filed: 04/29/2013
• Published: 10/30/2014
• Est. Priority Date: 04/29/2013
• Status: Abandoned Application

• Current Assignee: Elwha LLC (Intellectual Ventures LLC)
• Original Assignee: Elwha LLC (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Kindsvogel, Wayne R., McKnight, Gary L.
• Application Number:
  US13/872,578
• Publication Number:
  US 20140323819A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 10/0051 for taking saliva or sputum samples devices for receiving spittle A61J9/00
• CPC Class Codes: A61B 2010/0003 including means for analysis by an unskilled person
• CPC Class Codes: A61B 2562/0295 Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157 disposable multilayered or laminated electrodes G01N27/307; details of handling chemical test elements G01N33/4875
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/682 Mouth, e.g., oral cavity; tongue; Lips; Teeth

Abstract

Disposable test units to assist medical personnel are described. In some embodiments, a test unit includes: a solid support; a cavity in the solid support; a reaction chamber internal to the solid support, including a plurality of biochemical reagents; a first internal channel in the solid support, connected at a first end to the cavity, connected at a second end to the reaction chamber; at least one pathogen detection region internal to the solid support; a second internal channel in the solid support, connected at a first end to the reaction chamber, connected at a second end to the at least one pathogen detection region; a temperature detector; and a persistent visible temperature indicator attached to the temperature detector.

Claims

1. A test unit, comprising:

a solid support including a surface configured to reversibly mate with a skin surface of an individual;

a cavity in the solid support;

a reaction chamber internal to the solid support, the reaction chamber including a plurality of detection agents within a space;

a first internal channel in the solid support, the first internal channel connected at a first end to the cavity, the first internal channel connected at a second end to the reaction chamber;

at least one pathogen detection region internal to the solid support, each of the at least one pathogen detection region including a visible indicator of one or more of the plurality of detection agents;

a second internal channel in the solid support, the second internal channel connected at a first end to the reaction chamber, the second internal channel connected at a second end to the at least one pathogen detection region;

a temperature detector affixed to the solid support; and

a persistent visible temperature indicator attached to the temperature detector.

2. The test unit of claim 1, wherein the solid support including the surface configured to reversibly mate with the skin surface of an individual comprises:

a substantially flat solid support.

4. The test unit of claim 1, wherein the solid support including the surface configured to reversibly mate with the skin surface of an individual comprises:

a plurality of layers combined to form a structure of the solid support.

5. The test unit of claim 1, wherein solid support including the surface configured to reversibly mate with the skin surface of an individual comprises:

a surface configured for placement adjacent to the skin surface; and

bio-compatible adhesive on the surface configured for placement adjacent to the skin.

10. The test unit of claim 1, wherein the reaction chamber internal to the solid support, the reaction chamber including the plurality of detection agents within the space comprises:

one or more detection agents including an antibody configured to bind with a pathogen protein.

11. The test unit of claim 1, wherein the reaction chamber internal to the solid support, the reaction chamber including the plurality of detection agents within the space comprises:

one or more detection agents including an enzyme.

13. The test unit of claim 1, wherein the at least one pathogen detection region internal to the solid support comprises:

a plurality of pathogen detection regions.

15. The test unit of claim 1, wherein the persistent visible temperature indicator attached to the temperature detector comprises:

a persistent chemical indicator.

16. The test unit of claim 1, wherein the persistent visible temperature indicator attached to the temperature detector comprises:

a persistent electronic indicator.

19. The test unit of claim 1, further comprising:

a sensor of a physiological condition affixed to the solid support; and

an indicator attached to the sensor of the physiological condition.

20. The test unit of claim 19, wherein the sensor of a physiological condition comprises:

a sensor of a sweat level on the skin surface of the individual at a location adjacent to the solid support.

21. The test unit of claim 1, further comprising:

a processor attached to both the at least one pathogen detection region internal to the solid support and to the temperature detector affixed to the solid support, the processor configured to accept information; and

a visual indicator attached to the processor.

3. (canceled)

6-9. -9. (canceled)

12. (canceled)

14. (canceled)

17-18. -18. (canceled)

22. A test unit, comprising:

a solid support including a surface configured to reversibly mate with a skin surface of an individual;

a nasal fluid receiving cavity in the solid support;

a reaction chamber internal to the solid support, the reaction chamber including a plurality of detection agents within a space;

a first internal channel to the solid support, the first internal channel including a first end attached to the nasal fluid receiving cavity, the first internal channel including a second end attached to the reaction chamber;

at least one pathogen detection region internal to the solid support, each of the at least one pathogen detection region including a visible indicator of one or more of the plurality of detection agents;

at least one second internal channel to the solid support, the at least one second internal channel including a first end attached to the reaction chamber, the at least one second internal channel including a second end attached to the at least one pathogen detection region;

a temperature detector affixed to the solid support; and

a persistent visible temperature indicator attached to the temperature detector.

23. The test unit of claim 22, wherein the solid support including the surface configured to reversibly mate with the skin surface of the individual comprises:

a substantially flat solid support.

25. The test unit of claim 22, wherein the solid support including the surface configured to reversibly mate with the skin surface of the individual comprises:

a plurality of layers combined to form a structure of the solid support.

26. The test unit of claim 22, wherein the solid support the surface configured to reversibly mate with the skin surface of the individual comprises:

a surface configured for placement adjacent to the skin surface; and

bio-compatible adhesive on the surface configured for placement adjacent to the skin surface.

30. The test unit of claim 22, wherein the reaction chamber internal to the solid support, the reaction chamber including the plurality of detection agents within the space comprises:

one or more detection agents including an antibody configured to bind with a pathogen protein.

31. The test unit of claim 22, wherein the reaction chamber internal to the solid support, the reaction chamber including the plurality of detection agents within the space comprises:

one or more detection agents including an enzyme.

33. The test unit of claim 22, wherein the at least one pathogen detection region internal to the solid support comprises:

a plurality of pathogen detection regions.

35. The test unit of claim 22, wherein the temperature detector affixed to the solid support comprises:

a chemical-based temperature detector.

37. The test unit of claim 22, wherein the temperature detector affixed to the solid support comprises:

an electronic temperature detector.

40. The test unit of claim 22, further comprising:

a sensor of a physiological condition of the individual affixed to the solid support; and

an indicator attached to the sensor of the physiological condition of the individual.

41. The test unit of claim 40, wherein the sensor of the physiological condition comprises:

a sensor of a sweat level on the skin surface of the individual at a location adjacent to the solid support.

42. The test unit of claim 22, further comprising:

a processor attached to both the at least one pathogen detection region internal to the solid support and to the temperature detector affixed to the solid support, the processor configured to accept information; and

a visual indicator attached to the processor.

24. (canceled)

27-29. -29. (canceled)

32. (canceled)

34. (canceled)

36. (canceled)

38-39. -39. (canceled)

43. A test unit, comprising:

a solid support including a region configured to be enclosed within an oral cavity of an individual;

an oral fluid receiving cavity in the solid support;

a reaction chamber internal to the solid support, the reaction chamber including a plurality of detection agents within a space;

a first internal channel to the solid support, the first internal channel including a first end attached to the oral fluid receiving cavity, the first internal channel including a second end attached to the reaction chamber;

at least one pathogen detection region internal to the solid support, each of the at least one pathogen detection region including a visible indicator of one or more of the plurality of detection agents;

at least one second internal channel to the solid support, the at least one second internal channel including a first end attached to the reaction chamber, the at least one second internal channel including a second end attached to the at least one pathogen detection region;

a temperature detector affixed to the solid support; and

a persistent visible temperature indicator attached to the temperature detector.

47. The test unit of claim 43, wherein the solid support including the region configured to be enclosed within the oral cavity of the individual comprises:

one or more conduits within a structure of the solid support.

48. The test unit of claim 43, wherein the solid support including the region configured to be enclosed within the oral cavity of the individual comprises:

a first region configured to fit within the oral cavity; and

a second region configured to be positioned outside the oral cavity, wherein the persistent visible temperature indicator and the at least one pathogen detection region are affixed to the second region.

52. The test unit of claim 43, wherein the reaction chamber internal to the solid support comprises:

one or more detection agents including an antibody configured to bind with a pathogen protein.

53. The test unit of claim 43, wherein the reaction chamber internal to the solid support comprises:

one or more detection agents including an enzyme.

56. The test unit of claim 43, wherein the at least one pathogen detection region comprises:

a plurality of pathogen detection regions.

58. The test unit of claim 43, wherein the temperature detector affixed to the solid support comprises:

a chemical-based temperature detector.

59. The test unit of claim 43, wherein the temperature detector affixed to the solid support comprises:

an electronic temperature detector.

60. The test unit of claim 43, wherein the persistent visible temperature indicator attached to the temperature detector comprises:

a persistent chemical indicator.

61. The test unit of claim 43, wherein the persistent visible temperature indicator attached to the temperature detector comprises:

a persistent electronic indicator.

64. The test unit of claim 43, further comprising:

a sensor of a physiological condition within the oral cavity, the sensor affixed to the solid support at the region configured to be enclosed within the oral cavity of the individual.

65. The test unit of claim 43, further comprising:

a processor attached to both the at least one pathogen detection region internal to the solid support and to the temperature detector affixed to the solid support, the processor configured to accept information; and

a visual indicator attached to the processor.

44-46. -46. (canceled)

49-51. -51. (canceled)

54-55. -55. (canceled)

57. (canceled)

62-63. -63. (canceled)

66. A test unit, comprising:

a solid support including a surface configured to reversibly mate with a skin surface of an individual;

a cavity in the solid support;

at least one pathogen detection region internal to the solid support, each of the at least one pathogen detection region including an electronic detector of at least one analyte;

an internal channel in the solid support, the internal channel connected at a first end to the cavity, the internal channel connected at a second end to the at least one pathogen detection region;

an electronic temperature detector affixed to the solid support;

a processor attached to both the electronic detector and the electronic temperature detector; and

a persistent visible indicator attached to the processor.

67. The test unit of claim 66, further comprising:

a reaction chamber internal to the solid support, the reaction chamber including a plurality of detection agents within a space, the reaction chamber attached to the internal conduit, the plurality of detection agents detectable by the electronic detector.