MULTI-CHAMBER MIXING CONTAINER

• US 20140334252A1
• Filed: 12/20/2012
• Published: 11/13/2014
• Est. Priority Date: 12/22/2011
• Status: Abandoned Application

• Current Assignee: B Braun Melsungen AG (B. Braun Holding GmbH & Co. KG)
• Original Assignee: B Braun Melsungen AG (B. Braun Holding GmbH & Co. KG)
• Inventors: Beine, Joachim, Harand, Ralf, Krueger, Volker, Vonhof, Sandra
• Application Number:
  US14/361,615
• Publication Number:
  US 20140334252A1
• Time in Patent Office: Days
• US Class Current: 366/348
• CPC Class Codes: A61M 2005/31518 designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
• CPC Class Codes: A61M 5/2425 by compression of deformable ampoule or carpule wall
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2459 upon internal pressure increase, e.g. pierced or burst A61M5/2429 takes precedence
• CPC Class Codes: A61M 5/2466 by piercing without internal pressure increase A61M5/2429 takes precedence
• CPC Class Codes: B01F 2101/22 Mixing of ingredients for pharmaceutical or medical compositions
• CPC Class Codes: B01F 23/40 Mixing liquids with liquids; Emulsifying
• CPC Class Codes: B01F 23/50 Mixing liquids with solids displacing one liquid by another in dispersions of solids in liquids B01D12/00
• CPC Class Codes: B01F 33/50112 of the syringe or cartridge type
• CPC Class Codes: B01F 35/7137 Piercing, perforating or melting membranes or closures which seal the compartments
• CPC Class Codes: B65D 81/32 for packaging two or more different materials which must be maintained separate prior to use in admixture containers with removable or destructible partitions B65D25/08 ; closures combined with auxiliary containers B65D51/28; in aerosol containers B65D83/682; amalgam capsules A61C5/66; containers for pharmaceutical purposes A61J1/20, A61M5/19; medical syringes A61M3/005, resin cartridges for grouting anchoring-bolts in mines E21D20/026

Abstract

The invention is related to a multi-chamber mixing container comprising an introversion container, a withdrawal container and various optionally present intermediate containers, furthermore a device for the reception and use of the multi-chamber mixing container and methods for mixing liquids or liquids and solids under aseptic conditions in the multi-chamber mixing container.

Claims

1-15. -15. (canceled)

16. Multi-chamber mixing container comprising:

an introversion container; and

a withdrawal container;

wherein the introversion container is filled with a liquid and sealed with a pierceable sealing foil on the front side and its bottom is pushable in the direction of the sealing foil and the wall is introversible to the inside; and

wherein the withdrawal container is filled with a liquid or a solid and sealed on the top side with a pierceable sealing foil and has a withdrawal area at the bottom side; and

wherein the introversion container and the withdrawal container are connected with each other in a sealing manner.

17. Multi-chamber mixing container according to claim 16, wherein the front side of the introversion container sealed with the pierceable sealing foil and the top side of the withdrawal container sealed with the pierceable sealing foil are connected with each other in a sealing manner.

18. Multi-chamber mixing container according to claim 16, wherein the outer face of the introversion container has a groove, a bead, a thread or a recess at the level of the sealing foil and/or the withdrawal container has a groove, a bead, a thread or a recess at the level of the sealing foil.

19. Multi-chamber mixing container according to claim 16, wherein the bottom of the introversion container has a piercing nose or protrusion or bulge formed in the direction of the sealing foil and positioned centrally or the bottom is shaped concave.

20. Multi-chamber mixing container according to claim 19, wherein the piercing nose or the protrusion or the bulge or the concavely shaped bottom has canals, furrows, corrugations, star-shaped indentations, mounds, knobs, pins or other surface irregularities.

21. Multi-chamber mixing container according to claim 16, wherein the introversible wall of the introversion container has circumferential notch lines.

22. Multi-chamber mixing container according to claim 16, consisting of the introversion container and the withdrawal container and an intermediate container filled with a liquid or a solid and located in between the introversion container and the withdrawal container, wherein the intermediate container is sealed on the top side and on the bottom side with a pierceable sealing foil and the intermediate container is connected with the introversion container in a sealing manner and with the withdrawal container in a sealing manner.

23. Multi-chamber mixing container according to claim 16, consisting of the introversion container and the withdrawal container and two intermediate containers each filled with a liquid or a solid and located in between introversion container and withdrawal container, wherein both intermediate containers are sealed on the top side and on the bottom side with a pierceable sealing foil and both intermediate containers are connected with each other in a sealing manner and the first intermediate container is connected with the introversion container in a sealing manner and the other intermediate container is connected with the withdrawal container in a sealing manner.

24. Multi-chamber mixing container according to claim 16, wherein the multi-chamber mixing container consists of the introversion container and the withdrawal container and has on the outside along the connecting line between the introversion container and the withdrawal container a groove.

25. Multi-chamber mixing container according to claim 22, wherein the multi-chamber mixing container consisting of the introversion container, the intermediate container and the withdrawal container has on the outside along the connecting line between the introversion container and the intermediate container and/or between the intermediate container and the withdrawal container a groove

26. Multi-chamber mixing container according to claim 23, wherein the multi-chamber mixing container consisting of the introversion container, the two intermediate containers and the withdrawal container has on the outside along the connecting line between the introversion container and the first intermediate container and/or between the both intermediate containers and/or between the other intermediate container and the withdrawal container a groove.

27. Multi-chamber mixing container according to claim 22, wherein for the sealing connection between introversion container and intermediate container and between intermediate container and withdrawal container, the introversion container, the intermediate container and the withdrawal container have a groove, a bead, a thread or a recess at the level of the sealing foil.

28. Multi-chamber mixing container according to claim 23, wherein for the sealing connection between introversion container and the first intermediate container and between the first and the other intermediate container and between the other intermediate container and the withdrawal container, the introversion container, the first intermediate container, the other intermediate container and the withdrawal container have a groove, a bead, a thread or a recess at the level of the sealing foil.

29. Multi-chamber mixing container according to claim 16, wherein the introversion container is filled completely with a liquid.

32. Method for the aseptic preparation of a solution from at least two components, characterized by the insertion of a multi-chamber mixing container according to claim 16 in a device comprising a receptacle in the shape of a half-shell for the multi-chamber mixing container, mounting means for the multi-chamber mixing container and an expression plunger movable in the axial direction, exertion of pressure by the expression plunger onto the bottom of the introversion container, pushing the bottom of the introversion container in the direction of the withdrawal container, whereat the wall of the introversion container is continuously introverting to the inside and with onward pushing the sealing foils are pierced and mixing of the at least two components.

30. Kit comprising at least one introversion container that is sealed with a pierceable sealing foil on the front side and its bottom is pushable in the direction of the sealing foil and the wall is introversible to the inside and at least one withdrawal container that is sealed on the top side with a pierceable sealing foil and has a withdrawal area at the bottom side, wherein, the introversion container and the withdrawal container are connectable with each other in a sealing manner.

31. Kit according to claim 30, further comprising at least one intermediate container that is sealed on the top side and on the bottom side with a pierceable sealing foil, wherein the intermediate container is connectable with the introversion container in a sealing manner and with the withdrawal container in a sealing manner.