HUMAN MILK OLIGOSACCHARIDES FOR PREVENTING INJURY AND/OR PROMOTING HEALING OF THE GASTROINTESTINAL TRACT

• US 20140335065A1
• Filed: 08/13/2012
• Published: 11/13/2014
• Est. Priority Date: 08/29/2011
• Status: Active Grant

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Davis, Steven R., Chow, Jomay
• Granted Patent: US 10,639,319 B2
• Time in Patent Office: Days
• US Class Current: 424/93.44
• CPC Class Codes: A23L 33/21 Addition of substantially indigestible substances, e.g. dietary fibres
• CPC Class Codes: A23L 33/28 Substances of animal origin, e.g. gelatin or collagen
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 2035/115 Probiotics
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 35/741 Probiotics probiotic yeast, e.g. saccharomyces A61K36/06
• CPC Class Codes: A61K 35/744 Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61K 35/747 Lactobacilli, e.g. L. acidophilus or L. brevis
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system

Abstract

Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to individuals including preterm infants, infants, toddlers, children, and adults for preventing injury and/or improving the healing of the gastrointestinal tract. Additional suitable methods of using the nutritional compositions including the human milk oligosaccharides are also disclosed.

Claims

1. A method to enhance healing of an individual'"'"'s gastrointestinal tract, the method comprising:

administering a nutritional composition comprising a human milk oligosaccharide to an individual having an injured gastrointestinal tract.

2. The method of claim 1 wherein the gastrointestinal tract is injured as a result of at least one of antibiotic therapy, radiation therapy, chemotherapy, surgery, enteric infection, inflammatory bowel disease, colitis, bowel obstruction, and chronic stress.

3. The method of claim 1 wherein the nutritional composition comprises at least one of 3′

-Sialyllactose, 6′

-Sialyllactose, 2′

-Fucosyllactose, 3′

-Fucosyllactose, Lacto-N-neotetraose, and Disialyllacto-N-tetraose.

4. The method of claim 3 wherein the nutritional composition comprises 2′

-Fucosyllactose.

5. The method of claim 1 wherein the nutritional composition further comprises at least one probiotic.

6. A method of reducing the incidence of intestinal mucosa injury, the method comprising:

administering a nutritional composition comprising a human milk oligosaccharide to an individual susceptible to an intestinal mucosa injury.

7. The method of claim 6 wherein the nutritional composition comprises at least one of 3′

-Sialyllactose, 6′

-Sialyllactose, 2′

-Fucosyllactose, 3′

-Fucosyllactose, Lacto-N-neotetraose, and Disialyllacto-N-tetraose.

8. The method of claim 7 wherein the nutritional composition comprises 2′

-Fucosyllactose.

9. The method of claim 6 wherein the nutritional composition further comprises at least one probiotic.

10. The method of claim 6 wherein the nutritional composition is selected from the group consisting of a human milk fortifier, an infant formula, a pediatric formula, a follow on formula, and an adult nutritional composition.

11. A method of improving the barrier function in an individual'"'"'s gastrointestinal tract, the method comprising:

administering a nutritional composition comprising a human milk oligosaccharide to an individual in need of an increased barrier function of the gastrointestinal tract.

12. The method of claim 11 wherein the nutritional composition comprises at least one of 3′

-Sialyllactose, 6′

-Sialyllactose, 2′

-Fucosyllactose, 3′

-Fucosyllactose, Lacto-N-neotetraose, and Disialyllacto-N-tetraose.

13. The method of claim 12 wherein the nutritional composition comprises 2′

-Fucosyllactose.

14. The method of claim 11 wherein the nutritional composition further comprises at least one probiotic.

15. A method of reducing the incidence of inflammation in an individual'"'"'s gastrointestinal tract, the method comprising:

administering a nutritional composition comprising a human milk oligosaccharide to an individual susceptible to inflammation of the gastrointestinal tract.