MULTISPOT MONITORING FOR USE IN OPTICAL COHERENCE TOMOGRAPHY
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Abstract
Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.
311 Citations
28 Claims
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1. (canceled)
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2. A method for performing optical coherence tomography measurements to determine an analyte level in tissue, comprising:
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aligning an optical coherence tomography system to a subject through an optical coupler; scanning a beam over a first tissue site of the subject using the optical coupler to collect a first set of optical coherence tomography measurements; scanning the beam over at least a second tissue site of the subject using the optical coupler to collect a second set of optical coherence tomography measurements; selecting at least one tissue site from the first tissue site and the at least second tissue site for monitoring analyte levels, wherein the selected at least one tissue site comprises a tissue site that is valid for measuring an analyte level; processing optical coherence tomography measurements associated with the selected at least one tissue site to measure the analyte level in the tissue; and not processing optical coherence tomography measurements associated with at least one other tissue site not selected to for monitoring analyte levels. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method comprising:
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directing a beam of radiation suitable for optical coherence tomography measurements from a beam scanner to a plurality of different locations on a region of a skin surface to scan a plurality of different tissue sites associated with each different location; determining a subset of tissue sites that each include an analyte correlating region, wherein an analyte correlating region comprises a tissue site that is valid for measuring an analyte level; and monitoring, using the beam scanner, each of the subset of tissue sites determined to include analyte correlating regions and not monitoring at least a portion of tissue sites determined not to include analyte correlating regions. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification