MICRONEEDLE ARRAYS FOR BIOSENSING AND DRUG DELIVERY
First Claim
1. A device, comprising:
- an array of hollowed needles, wherein each needle comprises a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure exposing the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal; and
an array of wires that are coupled to the probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.
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Accused Products
Abstract
Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, â device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.
77 Citations
43 Claims
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1. A device, comprising:
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an array of hollowed needles, wherein each needle comprises a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure exposing the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal; and an array of wires that are coupled to the probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A device, comprising:
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a substrate that includes a microneedle with a hollowed interior located on one side of the substrate, wherein the microneedle includes a wall with an opening to the hollowed interior; an electrode including a probe, wherein the probe is disposed inside the hollowed interior; and a wire, wherein the wire is connected to the probe, wherein the electrode is functionalized by a coating over the probe to interact with an analyte to produce an electrical signal. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method to sense an analyte and deliver a therapeutic agent, comprising:
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detecting a signal produced by an analyte at an interface with a chemically functionalized probe configured to electrochemically interact with the analyte within a biological fluid, wherein the signal is transduced to an electrical signal by the chemically functionalized probe; processing the electrical signal to determine a parameter of the analyte; and based on the determined parameter, applying an electrical stimulus to a valve comprising a porous polymer film having pores of a reversibly tunable porosity, the valve attached to a container containing a therapeutic agent, wherein the electrical stimulus alters the permeability of the pores from a closed state to an open state, thereby releasing the therapeutic agent into the biological fluid. - View Dependent Claims (30, 31, 32, 33, 34)
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35. A device, comprising:
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a substrate that includes a plurality of microneedles with a hollowed interior located on one side of the substrate, wherein each of the microneedles includes a wall with an opening to the hollowed interior; a biosensor module, comprising; a plurality of sensing electrodes disposed inside the hollowed interior of a first group of the plurality of microneedles, the sensing electrodes including a probe, wherein the probe includes a functionalized coating configured to interact with an analyte within a fluid to produce an electrical signal, and a plurality of wires, wherein one wire of the plurality of wires is connected to the probe of the sensing electrodes; a processing unit in communication with the plurality of wires to receive the electrical signal and use the received electrical signal as data; and an actuator module, comprising; a polymer film having pores of a reversibly tunable porosity, wherein the polymer film is attached to an opposite side of the substrate, a plurality of protrusion structures disposed inside the hollowed interior of a second group of the plurality of microneedles, the protrusion structures including a channel between an opening in the substrate exposing the polymer film and an opening at a terminal end of the protrusion structure, a containment structure that contains a chemical substance positioned above the polymer film, wherein the containment structure includes one or more openings coupled to the polymer film positioned above the protrusion structures, and an actuator electrode attached to the polymer film, wherein the actuator electrode provides an electrical stimulus to trigger an expansion of the pores of the polymer film to an open state or a contraction the pores of the polymer film to a closed state, wherein the processing unit is in communication with the actuator electrode to generate the electrical stimulus based on the data. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43)
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Specification