BIOPOLYMER MULTI-LAYER MULTI-FUNCTIONAL MEDICAL DRESSING AND METHOD OF MAKING SAME

• US 20140336557A1
• Filed: 05/01/2014
• Published: 11/13/2014
• Est. Priority Date: 05/10/2013
• Status: Abandoned Application

• Current Assignee: Biovation LLC
• Original Assignee: Biovation LLC
• Inventors: Durdag, Kerem, Gunn, Valerie, Hamlyn, Robert, Pendleton, Brian, Etchells, Marc, Paul, Brittany
• Application Number:
  US14/267,161
• Publication Number:
  US 20140336557A1
• Time in Patent Office: Days
• US Class Current: 602/48
• CPC Class Codes: A61F 13/01008 characterised by the material
• CPC Class Codes: A61F 13/05 specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
• CPC Class Codes: A61L 15/26 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The Technology described herein applies to medical dressings designed to heal wounds in the area of advanced wound care, inclusive of Negative Pressure Wound Therapy (NPWT), and describes novel wound healing absorbent scaffolds and dressing based on natural and naturally-derived material and fibers, preferentially poly (lactic) acid fibers and alginate materials.

Claims

1. A medical dressing comprising a biopolymer layered structure, the biopolymer layered structure comprising:

a biodegradable, bioresorbable layer comprising a plurality of biodegradable, bioresorbable fibers, wherein the fibers are oriented to provide compression resistance and maintain paths for liquid-flow and air-flow, and a bioresorbable, biodegradable hydrophilic surface coating on a substantial number of the fibers;

the fibers incorporating one or more bioactive agents.

2. The medical dressing of claim 1, wherein the layered structure comprises one or more natural fibers selected from the group consisting of cotton, bamboo and sisal.

3. The medical dressing of claim 1, wherein the layered structure comprises one or more fibers manufactured from natural sources selected from the group consisting of polylactide, polyglycolide, poly-L-lactide, poly-DL-lactide, polycaprolactone, polyhydroxyalkanoate, viscose, polyethylene terephthalate and polypropylene.

4. The medical dressing of claim 3, wherein the fibers comprise polymers of polylactide.

5. The medical dressing of claim 1, wherein the bioresorbable hydrophilic surface coating is on a substantial number of the fibers located proximate to other layers of the medical dressing.

6. The medical dressing of claim 1, wherein each of the fibers in the plurality of fibers has a diameter of approximately 1 μ

M to 1 mm.

7. The medical dressing of claim 6, wherein each of the fibers in the plurality of fibers has a diameter of approximately 5 to 100 μ

M.

8. The medical dressing of claim 1, wherein the fibers are processed by one or more of being cut into a staple of selected length, carded, air-layered, needle-punched, vertically lapped, spirally wound, thermally bonded, or ultrasonically bonded.

9. The medical dressing of claim 8 wherein the fibers of the layered structure are vertically lapped or spirally wound.

10. The medical dressing of claim 1, wherein the bioresorbable hydrophilic surface coating comprises one or more of cellulose, alginate, gums, starch, chitosan, ethylene glycol, carrageenans, polyoxethylene and polylactic acid.

11. The medical dressing of claim 10 wherein the bioresorbable hydrophilic surface coating comprises polylactic acid.

12. The medical dressing of claim 10 wherein the bioresorbable hydrophilic surface coating comprises alginate.

13. The medical dressing of claim 1, wherein the bioactive agent is an antimicrobial agent.

14. The medical dressing of claim 13, wherein the antimicrobial bioactive agent comprises asilver species.

15. The medical dressing of claim 13, wherein the bioactive agent is a component of one or more of the fibers and the surface coating.

16. The medical dressing of claim 1, further comprising:

a) a semi-permeable layer over-lying the biopolymer layered structure and extending beyond the biopolymer layered structure to form a peripheral region, that is sealable to the skin of the subject; and

b) a port, coupled to the semi-permeable layer, that is connectable to a negative pressure generating device.

17. The medical dressing of claim 16, further comprising an adhesive layer disposed on the peripheral region, which causes adherence of the semi-permeable layer to the skin.

18. The medical dressing of claim 16, wherein the semi-permeable layer is defined by a moisture-vapor transmission rate of 1 to 1000 g/24 hr-m² (grams per 24 hour-meter squared).

19. The medical dressing of claim 1, where the diameter of the fibers is selected to provide a desired compression resistance between a range of 0% and 50%.

20. A method of treating a wound, the method comprising:

a) providing a wound dressing comprising (i) a bioresorbable biodegradable non-woven material comprising a plurality of bioresorbable fibers incorporating a bioactive agent, the wound dressing having a wound interface for contacting a surface of a wound, wherein the fibers are predominately oriented in a direction transverse to an exposed surface to provide compression resistance and maintain paths for liquid-flow and air-flow, and (ii) a bioresorbable hydrophilic surface coating on a substantial number of the fibers proximal to the wound interface;

b) applying said wound dressing to the wound with the bioresorbable hydrophilic surface in contact with the surface of the wound, thereby protecting the wound by providing resistance to compression, maintaining paths for air-flow and fluid-flow and removing exudate from the wound through one or more of absorption and negative pressure.

21. The method of claim 20, wherein the fibers are natural fibers selected from one or more of the group consisting of cotton, bamboo and sisal.

22. The method of claim 20, wherein the bioresorbable fibers comprise one or more synthetic fibers selected from the group consisting of polylactide, polyglycolide, poly-L-lactide, poly-DL-lactide, polycaprolactone, viscose, PET, and PHA.

23. The method of claim 20, wherein the fibers comprise polymers of polylactide.

24. The method of claim 20, wherein each of the fibers in the plurality of fibers has a diameter of about 1 μ

m to about 1 mm.

25. The method of claim 20, wherein the fibers are processed by one or more of being cut into staple of selected length, carded, air-layered, needle-punched, vertically lapped, spirally wound or thermally bonded.

26. The method of claim 20, wherein the bioresorbable hydrophilic surface coating comprises but is not limited to one or more of cellulose, alginate, carrageenans, gums, starch, ethylene glycol, poly-oxethylene and polylactic acid.

27. The method of claim 26, wherein the bioresorbable hydrophilic surface coating comprises polylactic acid.

28. The method of claim 26, wherein the bioresorbable hydrophilic surface coating comprises alginate.

29. The method of claim 20, wherein the bioresorbable surface coating wicks exudate from the wound.

30. The method of claim 20, further comprising removal of the exudate from the surface coating by negative pressure.

31. The method of claim 20, wherein a bioactive agent is incorporated into one or more of the fibers and the surface coating.

32. The method of claim 20 wherein the bioactive agent is an antimicrobial agent.

33. The method of claim 32, wherein the antimicrobial bioactive agent comprises a mixture of two or more components selected from a group consisting of (i)—

silver ion-exchange particles, (ii) silver in the form of a water-soluble matrix, and (iii) silver in the form of metal coated fibers.

34. The method of claim 20, wherein the exudate is removed by a vacuum.

35. The method of claim 20, wherein the wound dressing is placed into the wound so as to fill 25% or more of the volume of the wound.