Systems And Methods For Injecting Cellular Fluids

• US 20140336615A1
• Filed: 11/28/2012
• Published: 11/13/2014
• Est. Priority Date: 12/02/2011
• Status: Abandoned Application

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Bayer Medical Care Inc. (Bayer AG)
• Inventors: Uram, Martin J., Levin, Paul D., Trombley, Frederick W. III, Trocki, Mark
• Application Number:
  US14/361,357
• Publication Number:
  US 20140336615A1
• Time in Patent Office: Days
• US Class Current: 604/506
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2005/14292 Computer-based infusion planning or simulation of spatio-temporal infusate distribution
• CPC Class Codes: A61M 2202/09 Body tissue
• CPC Class Codes: A61M 2205/3372 Temperature compensation
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: F04C 2270/041 Controlled or regulated
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

A system includes at least one pressurizing mechanism, a fluid path adapted to be placed in operative connection with the pressurizing mechanism to deliver an injectate to a patient, wherein the injectate includes cells, a control system operably associated with the at least one pressurizing mechanism; and at least one parameter generation system in operative connection with the control system. The parameter generation system includes an input system to receive data of a type of cells to be injected and is adapted to generate at least one parameter for the injection procedure at least in part on the basis of the data of the type of cells. The at least one parameter for the injection procedure may, for example, be a variable associated with the injectate, a variable associated with an injection protocol or a variable associated with at least one component of the fluid path.

Claims

1. A system, comprising:

at least one pressurizing mechanism;

a fluid path adapted to be placed in operative connection with the at least one pressurizing mechanism to deliver an injectate to a patient, the injectate comprising cells;

a control system operably associated with the at least one pressurizing mechanism; and

at least one parameter generation system in operative connection with the control system and comprising an input system to receive data of a type of cells to be injected, the at least one parameter generation system being adapted to generate at least one parameter for an injection procedure at least in part on the basis of the data of the type of cells.

2. The system of claim 1 wherein the at least one parameter for the injection procedure is a variable associated with the injectate, a variable associated with an injection protocol or a variable associated with at least one component of the fluid path.

3. The system of claim 2 wherein the variable associated with the injection protocol is a flow rate, an injection volume, an injection delay, a duration of injection, an acceleration, or a deceleration injection rate.

4. The system of claim 2 wherein the variable associated with the injectate is an initial concentration of cells, a temperature, an agitation or mixing condition, a composition, or an injectate loading condition.

5. The system of claim 2 wherein the variable associated with the at least one component of the fluid path is an identity of the component, a volume, a length, an inner diameter, a material composition, a surface condition, an internal surface coating, or an internal geometrical configuration.

6. The system of claim 5 wherein the at least one component of the fluid path is a needle and the variable associated with the at least one component is a length, an inner diameter, an outer diameter, a curvature, a material composition, a surface condition, an internal surface coating, an internal geometrical configuration, or a number of exit holes.

7. The system of claim 2 wherein the parameter generation system is adapted to be in communicative connection with a memory system, the memory system having stored therein a database of parameters for injection procedures determined at least in part on the basis of the type of cell to be injected.

8. The system of claim 7 wherein the memory system is in communicative connection with the control system.

9. The system of claim 7 wherein the database of parameters for injection procedures comprises parameters determined via at least one optimization study associated with each of a plurality of types of cells.

10. The system of claim 1 wherein the fluid path comprises a container adapted to be placed in operative connection with the at least one pressurizing mechanism so that injectate within the container can be pressurized for delivery.

11. The system of claim 10 wherein the container is a syringe.

12. The system of claim 1 wherein the at least one parameter for the injection procedure is chosen at least in part to control differentiation of a cell that has the ability to differentiate.

13. The system of claim 1 further comprising at least one sensor to identify a fluid path component to be operatively connected to the pressurizing system.

14. An injector system for use in connection with a fluid path to deliver an injectate to a patient wherein the injectate comprises cells, comprising:

at least one pressurizing mechanism adapted to be placed in operative connection with the fluid path;

a control system operably associated with the at least one pressurizing mechanism; and

at least one parameter generation system in operative connection with the control system and comprising an input system to receive data of a type of cells to be injected, the parameter generation system being adapted to generate at least one parameter for the injection procedure at least in part on the basis of the data of the type of cells.

15. A method of injecting an injectate comprising cells in an injection procedure, comprising:

placing a fluid path in operative connection with a pressurizing mechanism to deliver the injectate to a patient; and

generating at least one parameter for the injection procedure at least in part on the basis of the data of the type of cells.

16. The method of claim 15 wherein generating the at least one parameter comprises transmitting the at least one parameter from a database of parameters for injection procedures determined at least in part on the basis of the type of cell to be injected.

17. The method of claim 16 wherein the database of parameters for injection procedures comprises parameters determined via at least one optimization study associated with each of a plurality of types of cells.

18. The method of claim 17 wherein one cell characteristic is optimized or a plurality of cell characteristics are optimized as a group.

19. The method of claim 17 wherein one parameter for the injection procedure is optimized or a plurality of parameters for the injection procedure are optimized as a group.

20. A method of controlling the differentiation of a cell that has the ability to differentiate, comprising:

controlling at least one parameter of a fluid comprising the cell or of flow of the fluid comprising the cell through a fluid path.

21. A system, comprising:

at least one pressurizing mechanism;

a fluid path adapted to be placed in operative connection with the at least one pressurizing mechanism to deliver an injectate to a patient, the injectate comprising a biologic;

a control system operably associated with the at least one pressurizing mechanism; and

at least one parameter generation system in operative connection with the control system and comprising an input system to receive data of a type of biologic to be injected, the at least one parameter generation system being adapted to generate at least one parameter for an injection procedure at least in part on the basis of the data of the type of biolgic biologic.

22. A method of injecting an injectate comprising a biologic in an injection procedure, comprising:

placing a fluid path in operative connection with a pressurizing mechanism to deliver the injectate to a patient; and

generating at least one parameter for the injection procedure at least in part on the basis of the data of the type of biologic.