COMPOSITIONS, DEVICES, AND METHODS FOR NICOTINE AEROSOL DELIVERY

• US 20140345635A1
• Filed: 05/21/2014
• Published: 11/27/2014
• Est. Priority Date: 05/22/2013
• Status: Active Grant

• Current Assignee: NJOY electronic cigarettes
• Original Assignee: NJOY electronic cigarettes
• Inventors: RABINOWITZ, Joshua, SCATTERDAY, Mark
• Granted Patent: US 11,202,470 B2
• Time in Patent Office: Days
• US Class Current: 131/352
• CPC Class Codes: A24B 15/16 of tobacco substitutes
• CPC Class Codes: A24B 15/167 in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
• CPC Class Codes: A24B 15/30 by organic substances A24B15/281 takes precedence
• CPC Class Codes: A24F 40/10 Devices using liquid inhalable precursors
• CPC Class Codes: A24F 40/50 Control or monitoring

Abstract

The present disclosure generally relates to compositions, and related devices and methods, useful in vaporizing devices such as electronic cigarettes. The composition may comprise nicotine, at least one solvent, and at least one ion pairing agent, and may be vaporized to form a condensation aerosol, wherein inhalation of the aerosol allows for deposition of nicotine with the respiratory system, including deep lung deposition. The vaporizing device may comprise a vaporization unit, a battery, and an integrated circuit coupled to the battery, wherein the integrated circuit is configured to control the battery for rapid initial vaporization without overheating, producing thermal degradation products, or draining battery energy. The battery may operate with pulse width modulation for at least a portion of the time the vaporizing device is being used.

Claims

1. A composition comprising nicotine, at least one solvent, and at least one ion pairing agent, wherein vaporization and condensation of the composition produces an aerosol, and wherein at least 85% of the nicotine by weight with respect to the total weight of the composition is in a particulate phase of the aerosol.

2. The composition of claim 1, wherein the nicotine is not in free base form.

3. The composition of claim 1, wherein the at least one solvent comprises at least one alcohol chosen from glycerol, propylene glycol, polyethylene glycol, or any combination thereof.

4. The composition of claim 1, wherein the at least one ion pairing agent comprises a compound having at least one carboxylic acid group.

5. The composition of claim 1, wherein the at least one ion pairing agent comprises an acid.

6. The composition of claim 5, when the at least one ion pairing agent comprises a monoprotic carboxylic acid.

7. The composition of claim 6, wherein the at least one ion pairing agent comprises lactic acid.

8. The composition of claim 1, wherein a pH of the composition is within a range of about pH 7 to about pH 8.

9. The composition of claim 8, wherein a pH of the aerosol is ±

0.3 pH of the pH of the composition.

10. The composition of claim 1, further comprising at least one agent chosen from menthol, a tobacco alkaloid compound, a preservative, or a combination thereof.

11. The composition of claim 1, comprising from about 1.5% to about 6.0% nicotine, from about 44% to about 48% glycerol, and from about 44% to about 48% propylene glycol, by weight with respect to the total weight of the composition.

12. The composition of claim 1, wherein the at least one ion pairing agent has a molar ratio with respect to nicotine ranging from about 1:

2 to about 1;

1 (ion pairing agent;

nicotine).

13. The composition of claim 12, wherein the at least one ion pairing agent comprises lactic acid.

14. The composition of claim 11, further comprising from about 0.1% to about 3.0% of at least one agent chosen from menthol, a tobacco alkaloid compound, a non-tobacco flavor, or a combination thereof, by weight with respect to the total weight of the composition.

15. An aerosol comprising nicotine, at least one solvent, and at least one ion pairing agent, wherein the aerosol is produced by vaporization and condensation of a composition comprising nicotine, the at least one solvent, and the at least one ion pairing agent, and wherein at least 85% of the nicotine by weight with respect to the total weight of the composition is in a particulate phase of the aerosol.

16. The aerosol of claim 15, wherein the aerosol comprises a plurality of particles having a mass median aerodynamic diameter between about 200 nm and about 4 μ

m.

17. The aerosol of claim 16, wherein the particles have a mass median aerodynamic diameter between about 500 nm and about 1 μ

m.

18. The aerosol of claim 15, wherein at least 88% of the nicotine by weight with respect to the total weight of the composition is in the particulate phase of the aerosol.

19. The aerosol of claim 15, wherein the at least one ion pairing agent has a molar ratio with respect to nicotine ranging from about 1:

2 to about 1;

1 (ion pairing agent;

nicotine).

20-32. -32. (canceled)

33. A composition comprising nicotine, at least one solvent, and at least one ion pairing agent, wherein vaporization and condensation of the composition produces an aerosol, and wherein the at least one ion pairing agent has a molar ratio with respect to nicotine ranging from about 1:

2 to about 1;

1 (ion pairing agent;

nicotine).

34. The composition of claim 33, wherein the at least one ion pairing agent comprises a monoprotic carboxylic acid.

35. A composition comprising nicotine, at least one solvent, and at least one ion pairing agent comprising at least one carboxylic acid group, wherein vaporization and condensation of the composition produces an aerosol, and wherein the at least one ion pairing agent has an acid group molar ratio with respect to nicotine ranging from about 1:

2 to about 1;

1 (carboxylic acid group(s) of ion pairing agent;

nicotine).

36. The composition of claim 35, wherein the at least one ion pairing agent comprises a monoprotic carboxylic acid.

37-69. -69. (canceled)