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INDUCTION OF EXON SKIPPING IN EUKARYOTIC CELLS

  • US 20140350076A1
  • Filed: 07/15/2014
  • Published: 11/27/2014
  • Est. Priority Date: 09/21/2000
  • Status: Abandoned Application
First Claim
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1. An isolated antisense oligonucleotide of 14 to 40 nucleotides comprising a part of hAON#23 (5′

  • -TGGCATTTCTAGTTTGG-3′

    (SEQ ID NO;

         18)),wherein said oligonucleotide induces skipping of exon 51 of the dystrophin pre-mRNA in a cell, said oligonucleotide comprising a modification for increasing its resistance to an endonuclease in a cell.

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