OPTICAL SYSTEMS AND METHODS FOR RATIOMETRIC MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION

• US 20140350364A1
• Filed: 08/07/2014
• Published: 11/27/2014
• Est. Priority Date: 02/06/2007
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Markle, David R., Wessling, Ritchie A., Kolehmainen, Donald J.
• Granted Patent: US 9,839,378 B2
• Time in Patent Office: Days
• US Class Current: 600/316
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters

Abstract

Novel optical devices, methods and systems relating to the detection of glucose, and more particularly to real-time glucose monitoring, are disclosed herein. More particularly, various hardware and methodological means are disclosed for ratiometric correction of optical glucose measurements for artifacts of optical systems.

Claims

1-19. -19. (canceled)

20. An optical device for determining blood glucose concentration, comprising:

an excitation light source that emits an excitation light signal;

a fiber optic sensor optically coupled to the excitation light source and comprising an indicator system comprising a fluorophore operably coupled to a glucose binding moiety, wherein upon absorption of at least a portion of the excitation light signal, the indicator system emits at least a first emission light signal and a second emission light signal, wherein the first and second emission light signals are related to glucose concentrations, and wherein a ratio of the first and second emission light signals is glucose insensitive and sensitive to pH; and

a detector system operably coupled to at least the sensor, wherein the detector system comprises a means for detecting the emission light signals.

21. The optical device of claim 20, wherein the means for detecting the emission light signals comprises a microspectrometer.

22. The optical device of claim 20, wherein the means for detecting the emission light signals comprises at least two light detectors.

23. The optical device of claim 20, further comprising a data processing device in communication with the detector system, wherein the data processing device determines the blood glucose concentration substantially corrected for artifacts of the optical device unrelated to the blood glucose concentration by performing a ratiometric analysis of the emission light signals.

24-40. -40. (canceled)