Intravascular Cerebral Catheter Device and Method of Use

• US 20140350512A1
• Filed: 07/15/2014
• Published: 11/27/2014
• Est. Priority Date: 03/24/2008
• Status: Abandoned Application

• Current Assignee: Joe Sam Robinson
• Original Assignee: Joe Sam Robinson
• Inventors: Robinson, Joe Sam
• Application Number:
  US14/331,353
• Publication Number:
  US 20140350512A1
• Time in Patent Office: Days
• US Class Current: 604/503
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61L 33/0011 Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 25/0026 Multi-lumen catheters with stationary elements catheter assemblies comprising a catheter in combination with a guide tube, sheath or sleeve A61M2025/0681; catheters comprising telescoping coaxial elements A61M2025/0175
• CPC Class Codes: A61M 25/0045 multi-layered, e.g. coated coating materials A61L29/08
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/16854 by monitoring line pressure
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Cerebral Catheter devices and methods for use are provided. The catheter devices provided may include an anti-thrombotic agent coating on the exterior surface. The catheter devices may include unique tip configurations to allow improved fluid delivery capabilities. Further, the catheter devices may also or alternatively include one or more sensor devices in communication with a controller that allow automatically adjusting the delivery of a therapeutic fluid, for example a vasodilator, in response to the condition sensed by the catheter device, such as increased pressure. Moreover, the catheter devices may also be used in conjunction with blood flow transducers to detect and timely prevent and treatment vasospasms or other conditions. Methods for preventing and treatment vasospasm, neoplasm, or other pathological conditions while prolonged using the catheter device are also provided.

Claims

1. A catheter device, comprising:

an elongate catheter body, comprising a distal end and a proximal end;

at least one lumen extending from the proximal end to the distal end of the elongate catheter body;

a distal sensor device affixed to the elongate catheter body substantially near the distal end, wherein the distal sensor device generates a signal that is a distal pressure;

a controller in communication with the distal sensor device, and

a fluid delivery device in fluid communication with the at least one lumen and in electrical communication with the controller;

wherein said catheter device is a cerebral catheter device configured to be inserted into cerebral arteries;

wherein the controller is configured to store one or more signals collected over time as historical signals corresponding to one or more historical distal pressure measurements and to perform an analysis comprising comparing;

the signal generated from the distal sensor device to the historical signals and determine whether the first signal is greater than or lower than at least one of the historical signals, and cause an

(a) increase in fluid delivery to the at least one lumen from the fluid delivery device if the distal pressure is at a first predefined limit greater than at least one of the historical distal pressures, or

(b) decrease in fluid delivery to the at least one lumen from the fluid delivery device if the distal pressure is at a second predefined limit lower than at least one of the historical pressures.

2. The catheter device of claim 1, wherein the analysis performed by the controller comprises determining a ratio of the distal pressure to at least one of the historical distal pressures, and wherein if the ratio is at or exceeds a first predefined ratio limit, the fluid delivery is adjusted to be increased, and wherein if the ratio is below a second predefined ratio limit, the fluid delivery is adjusted to be decreased.

3. The catheter device of claim 2, wherein the first predefined ratio limit and the second predefined ratio limit comprise the same value.

4. The catheter device of claim 1, wherein the fluid delivery device delivers a fluid comprising at least a saline solution comprising a vasodilator, an anti-thrombotic agent, an antibiotic, a chemotherapeutic agent, other suitable therapeutic agent, or combination thereof.

5. The catheter device of claim 1, further comprising an anti-thrombotic agent at least partially coated or deposited thereon.

6. The catheter device of claim 5, wherein the anti-thrombotic agent comprises a coating applied to substantially an entire surface of the elongate catheter body.

7. The catheter device of claim 5, wherein the anti-thrombotic agent is at least partially impregnated into the elongate catheter body.

8. The catheter device of claim 5, wherein the anti-thrombotic agent is deposited at least partially in an interior surface of the catheter device comprising the at least one lumen.

9. The catheter device of claim 5, wherein the anti-thrombotic agent is time releasable.

10. The catheter device of claim 1, wherein the distal end of the catheter device further comprises a perforated tip affixed thereon, wherein the perforated tip comprises a rounded or substantially planar surface on a distal end of the perforated tip, and a plurality of perforated orifices on the rounded or substantially planar surface and extending through the perforated tip and in fluid communication with the at least one lumen.

11. The catheter device of claim 10, wherein the at least one lumen comprises a first and a second lumen, wherein the plurality of perforated orifices further comprise at least one central orifice in communication with the first lumen, and wherein the plurality of perforated orifices other than the at least one central orifice are in fluid communication with the second lumen.

12. The catheter device of claim 11, further comprising a secondary medical device passed through the first lumen and the at least one central orifice, wherein the secondary medical device comprises one of a guide wire and a balloon.

13. The catheter device of claim 10, wherein a fluid is delivered through the at least one lumen and the plurality of perforated orifices, wherein the fluid comprises at least one of a saline solution comprising a vasodilator, an anti-thrombotic agent, an antibiotic, a chemotherapeutic agent, other suitable therapeutic agent, or combination thereof.

14. The catheter device of claim 4, wherein said anti-thrombotic agent is selected from the group consisting of heparin, warfarin, synthetic pentasaccharide inhibitors of factor Xa, and derivatives thereof.

15. The catheter device of claim 4, wherein said vasodilator is verapamil.

16. A method for preventing and treating vasospasm using the catheter device of claim 1.

17. The method of claim 16, wherein said catheter device is used in conjunction with a blood flow transducer operable to detect a blood flow velocity and a presence of vasospasm.

18. The method of claim 17, wherein said blood flow transducer is an ultrasonic monitoring device.

19. The method of claim 17, wherein said blood flow transducer is implanted, recessed into, screwed onto, or temporarily attached to the patient'"'"'s skull.

20. The method of claim 17, wherein the blood flow velocity obtained from the blood flow transducer is supplied to the controller for adjusting delivery of a therapeutic fluid comprising a desired therapeutic agent.

21. A method for treating neoplasm using the catheter device of claim 1.

22. The method of claim 21, wherein said neoplasm is brain glioblastomas.

23. The catheter device of claim 1, wherein the controller includes instructions to increase a rate of the fluid delivery based on the distal signal and at least one of the one of the historical distal signals.

24. The catheter device of claim 23, wherein the rate of fluid delivery increase is proportional to a difference between the signal from the distal sensor device and at least one of the historical distal signals.

25. The catheter device of claim 10, wherein the perforated tip is inserted into or is inserted over the elongate catheter body.