COMPOSITIONS COMPRISING NECROSIS INHIBITORS, SUCH AS NECROSTATINS, ALONE OR IN COMBINATION, FOR PROMOTING AXON REGENERATION AND NERVE FUNCTION, THEREBY TREATING CNS DISORDERS
First Claim
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1. A method for promoting axon regeneration in a CNS neuron, the method comprising:
- exposing the CNS neuron to an effective amount of a necrosis inhibitor and an effective amount of an apoptosis inhibitor thereby to promote the regeneration of the axon.
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Abstract
Provided are methods for promoting axon regeneration of a Central Nervous System (CNS) neuron and promoting nerve function following injury to a CNS neuron, for example, brain and/or spinal cord injury. Axon regeneration in a CNS neuron or nerve function following injury to a CNS neuron can be promoted by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject suffering from a CNS disorder, wherein a symptom of the CNS disorder is axon degeneration.
7 Citations
27 Claims
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1. A method for promoting axon regeneration in a CNS neuron, the method comprising:
exposing the CNS neuron to an effective amount of a necrosis inhibitor and an effective amount of an apoptosis inhibitor thereby to promote the regeneration of the axon. - View Dependent Claims (2, 3, 11, 17, 19, 20, 21, 22, 24, 25, 26)
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4. (canceled)
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5. A method of preserving the viability of a CNS neuron, the method comprising:
administering to a subject in need thereof an effective amount of a necrosis inhibitor and an effective amount of an apoptosis inhibitor thereby to preserve the viability of the CNS neuron. - View Dependent Claims (6, 8, 9, 10)
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7. (canceled)
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12-14. -14. (canceled)
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15. A method of promoting axon regeneration in a CNS neuron, the method comprising:
reducing the production and/or activity of a RIP-1 kinase and/or a RIP-3 kinase in the CNS neuron thereby to promote axon regeneration in a CNS neuron. - View Dependent Claims (16, 18)
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23. (canceled)
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27-44. -44. (canceled)
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