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MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE

  • US 20140357855A1
  • Filed: 06/03/2014
  • Published: 12/04/2014
  • Est. Priority Date: 03/21/2003
  • Status: Abandoned Application
First Claim
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1. An isolated antisense oligonucleotide of 15 to 80 nucleotides comprising at least 15 bases of the sequence cuguugccuccgguucug (SEQ ID NO:

  • 29), wherein said oligonucleotide induces exon 53 skipping in the human dystrophin pre-mRNA, wherein each internucleoside linkage of the oligonucleotide is a phosphorothioate linkage.

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