PLATFORMS FOR MITRAL VALVE REPLACEMENT

• US 20140358222A1
• Filed: 12/20/2012
• Published: 12/04/2014
• Est. Priority Date: 12/21/2011
• Status: Active Grant

• Current Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Original Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Inventors: Gorman, Joseph H. III, Gorman, Robert C., Gillespie, Matthew J.
• Granted Patent: US 10,321,988 B2
• Time in Patent Office: Days
• US Class Current: 623/2.11
• CPC Class Codes: A61B 2017/00575 for closure at remote site, e.g. closing atrial septum defects
• CPC Class Codes: A61B 2017/00606 Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61F 2/2409 Support rings therefor, e.g. for connecting valves to tissue annuloplasty rings A61F2/2442
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2436 Deployment by retracting a sheath
• CPC Class Codes: A61F 2/2445 Annuloplasty rings in direct contact with the valve annulus
• CPC Class Codes: A61F 2210/009 magnetic
• CPC Class Codes: A61F 2220/0025 Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2230/0095 Saddle-shaped
• CPC Class Codes: A61F 2250/006 modular

Abstract

A mitral valve prosthesis is percutaneously and/or transapically deployed in at least two stages. In a first stage, a mitral annular ring platform adapted for percutaneous delivery is delivered to and anchored in the mitral valve annulus. In the second stage, a valved-stent mitral valve prosthetic device adapted for percutaneously delivery is delivered to the mitral valve annulus for mounting in the mitral annular ring platform. This approach provides a consistent platform for accepting valved-stent mitral valve prosthetic devices from different vendors to be used.

Claims

1. A mitral valve prosthesis comprising:

a mitral annular ring platform adapted for percutaneous and/or transapical delivery to and anchoring in the mitral valve annulus; and

a valved-stent mitral valve prosthetic device adapted to be percutaneously and/or transapically delivered to the mitral valve annulus for mounting in said mitral annular ring platform.

2. The mitral valve prosthesis of claim 1, wherein the mitral annular ring platform comprises a plurality of wires preformed into separate but contiguous helices, at least one of said helices being adapted to serve as an anchor on a first side of the valved-stent prosthesis when deployed, at least one of said helices being adapted to serve as an anchor on a second side of the valved-stent prosthesis when deployed, and at least one of said helices being adapted to fit snugly in the mitral valve annulus to connect the helices on the first and second sides of the valved-stent prosthesis when deployed and to provide a landing zone for the valved-stent mitral valve prosthesis.

3. The mitral valve prosthesis of claim 2, further comprising a sealing cuff disposed around said mitral annular ring platform, said sealing cuff comprising an absorbent material disposed at least partially circumferentially around the outer surface of said mitral annular ring platform, wherein said absorbent material expands by absorption of a fluid to substantially adhere said mitral annular ring platform to a mitral valve annulus, and wherein said expansion of said absorbent material is delayed for a time sufficient to permit positioning of said mitral annular ring platform at said mitral valve annulus.

4. The mitral valve prosthesis of claim 1, wherein the mitral annular ring platform comprises left and right discs having a central hollow region there between so as to allow left atrial access from the right atrium when said discs are deployed in a heart so as to straddle the atrial septum, at least one of said discs being adapted to fit into the mitral valve annulus, a mitral annular ring adapted to be implanted in an atrial septum across a mitral valve orifice and to accept the valved-stent mitral valve prosthesis, and a plug adapted to plug said hollow central region between the left and right discs.

5. The mitral valve prosthesis of claim 1, wherein the mitral annular ring platform comprises a first magnetic ring having a first polarity and adapted for placement in a left atrium in a supra mitral annular position via a patient'"'"'s femoral, jugular, or subclavian vein, and a second magnetic ring having a second polarity and adapted for placement on a ventricular side of the mitral annulus via a femoral artery, whereby said first and second magnetic rings are brought together to lock together magnetically so as to sandwich mitral valve tissue and mitral annulus circumferentially when deployed.

6. The mitral valve prosthesis of claim 1, wherein the mitral annular ring platform comprises a first petal-shaped wire ring having a hollow center and adapted for placement on an atrial side of the mitral annulus so as to exert downward pressure, and a second petal-shaped wire ring having a hollow center and adapted for placement on a ventricular side of the metal annulus so as to exert upward pressure, wherein said first and second petal-shaped wire rings overlap in central region thereof to apply opposing pressures when deployed.