Array of Sensors Functionalized with Systematically Varying Receptor Materials
First Claim
1. A device for detecting one or more analytes, the device comprising:
- a) a sensor array including at least three resonator sensors having respective receptor materials disposed thereon, wherein the receptor materials have a physical property relevant to their ability to bind or adsorb one or more of the analytes, and the physical property of the receptor materials systematically increases or decreases in degree from the receptor material on a first one of the sensors, to the receptor material on a second one of the sensors, and to the receptor material on a third one of the at least three sensors; and
b) detection means for detecting sensor responses when masses of one or more of the analytes are adsorbed or bound to the receptor materials on the sensors.
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Accused Products
Abstract
A sensor array includes resonator sensors having respective receptor materials disposed thereon. The receptor materials have a physical property relevant to their ability to bind or adsorb one or more analytes in a sample. The physical property of the receptor materials on the sensors systematically increases or decreases in degree from one sensor to the next in the array. The device also comprises at least one detector for detecting sensor responses when masses of the analytes are adsorbed or bound to the receptor materials on the sensors. With this graded panel of sensors in the array, the analytes may adsorb or bind to the functionalized sensors with a pattern of responses specific to each analyte.
9 Citations
46 Claims
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1. A device for detecting one or more analytes, the device comprising:
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a) a sensor array including at least three resonator sensors having respective receptor materials disposed thereon, wherein the receptor materials have a physical property relevant to their ability to bind or adsorb one or more of the analytes, and the physical property of the receptor materials systematically increases or decreases in degree from the receptor material on a first one of the sensors, to the receptor material on a second one of the sensors, and to the receptor material on a third one of the at least three sensors; and b) detection means for detecting sensor responses when masses of one or more of the analytes are adsorbed or bound to the receptor materials on the sensors. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A device for detecting one or more analytes, the device comprising:
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a) a sensor array including a plurality of resonator sensors having respective receptor materials disposed thereon, wherein the sensors are arranged in rows and columns, the receptor materials have a first physical property relevant to their ability to bind or adsorb one or more of the analytes, the first physical property of the receptor materials on the sensors in at least one of the rows systematically increases or decreases in degree from the receptor material on a first one of the sensors in the row to the receptor material on a last one of the sensors in the row, and the first physical property or a second physical property of the receptor materials on the sensors in at least one of the columns systematically increases or decreases in degree from the receptor material on a first one of the sensors in the column to the receptor material on a last one of the sensors in the column; and b) detection means for detecting sensor responses when masses of one or more of the analytes are adsorbed or bound to the receptor materials on the sensors. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method comprising:
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a) exposing a sensor array to a sample that potentially contains one or more analytes, wherein the sensor array includes at least three resonator sensors having respective receptor materials disposed thereon, wherein the receptor materials have a physical property relevant to their ability to bind or adsorb one or more of the analytes, and the physical property of the receptor materials systematically increases or decreases in degree from the receptor material on a first one of the sensors, to the receptor material on a second one of the sensors, and to the receptor material on a third one of the at least three sensors; b) detecting sensor responses to the sample; and c) determining from the sensor responses if the sample contains one or more of the analytes. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method comprising:
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a) exposing a sensor array to a sample that potentially contains one or more analytes, wherein the sensor array includes a plurality of resonator sensors having respective receptor materials disposed thereon, wherein the sensors are arranged in rows and columns, the receptor materials have a first physical property relevant to their ability to bind or adsorb one or more of the analytes, the first physical property of the receptor materials on the sensors in at least one of the rows systematically increases or decreases in degree from the receptor material on a first one of the sensors in the row to the receptor material on a last one of the sensors in the row, and the first physical property or a second physical property of the receptor materials on the sensors in at least one of the columns systematically increases or decreases in degree from the receptor material on a first one of the sensors in the column to the receptor material on a last one of the sensors in the column; b) detecting sensor responses to the sample; and c) determining from the sensor responses if the sample contains one or more of the analytes. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45, 46)
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Specification