DEVICE FOR COLLECTING BODY FLUIDS

• US 20140364764A1
• Filed: 07/19/2012
• Published: 12/11/2014
• Est. Priority Date: 12/13/2011
• Status: Abandoned Application

• Current Assignee: Juvic Inc.
• Original Assignee: Industry Academic Cooperation Foundation
• Inventors: Jung, Hyung Il, Lee, Kwang, Li, Chengguo, Lee, Chang Yoel
• Application Number:
  US14/362,895
• Publication Number:
  US 20140364764A1
• Time in Patent Office: Days
• US Class Current: 600/579
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150099 by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150396 Specific tip design, e.g. for improved penetration characteristics
• CPC Class Codes: A61B 5/150969 Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
• CPC Class Codes: A61B 5/150984 Microneedles or microblades
• CPC Class Codes: A61B 5/15113 Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
• CPC Class Codes: A61B 5/15142 Devices intended for single use, i.e. disposable

Abstract

The present invention relates to a device for collecting body fluids, the device comprising: (a) an internal pressure adjustment means for adjusting the internal pressure of the device, and the internal pressure adjustment means has an internal space and is made of an elastic deformable material; (b) a fluid accommodation means, which is openly connected to the internal pressure adjustment means, for accommodating body fluids collected from the human body; and (c) a perforation means which is connected to the fluid accommodation means, is located at the lower part of the device, and comprises a hollow microstructure for forming an opening on the body.

Claims

1. A device for extraction of body fluids, the device comprising:

(a) an internal pressure regulator made of an elastically deformable material and having an internal space therein, the internal pressure regulator regulating the internal pressure of the device;

(b) a fluid reservoir openly connected to the internal pressure regulator and receiving body fluids extracted from the body; and

(c) a perforator connected to the fluid reservoir and disposed at a lower portion of the device, the perforator including a hollow microstructure that forms a hole in the body.

2. The device of claim 1, further comprising an outlet valve connected to the fluid reservoir and an inlet valve provided between the fluid reservoir and the hollow microstructure.

3. The device of claim 1, wherein the elastically deformable material is an epoxy polymer, a silicon polymer, or an acrylic polymer.

4. The device of claim 1, wherein the internal pressure regulator is deformed from its shape by a downward external pressure, resulting in reducing the volume of the internal space, thereby applying a perforation force to allow the hollow microstructure in contact with a body surface barrier to perforate the body surface barrier.

5. The device of claim 2, wherein the internal pressure regulator is deformed from its shape by a downward external pressure, resulting in reducing the volume of the internal space and thus increasing in the internal pressure of the device, thereby inducing the opening of the outlet value and the closing of the inlet valve and applying a perforation force to allow the hollow microstructure in contact with a body surface barrier to perforate the body surface barrier.

6. The device of claim 4, wherein the internal pressure regulator is restored to its original shape by the relaxing of the external pressure, resulting in producing a negative pressure inside the device, thereby allowing a fluid to flow into the fluid reservoir from the hollow microstructure in contact with the body surface barrier.

7. The device of claim 5, wherein the internal pressure regulator is restored to its original shape by the relaxing of the external pressure, resulting in producing a negative pressure inside the device and thus closing the outlet valve and opening the inlet valve, thereby allowing a fluid to flow into the fluid reservoir from the hollow microstructure in contact with the body surface barrier through the opened inlet valve.

8. The device of claim 6, wherein the internal pressure regulator after the relaxing of the external pressure is deformed from its shape by an application of a downward external pressure, resulting in reducing the volume of the internal pressure and thus increasing the internal pressure of the internal space, thereby allowing the fluid reserved in the fluid reservoir to flow out through the hollow microstructure.

9. The device of claim 7, wherein the internal pressure regulator after the relaxing of the external pressure is deformed from its shape by an application of a downward external pressure, resulting in reducing the volume of the internal pressure and thus increasing the internal pressure of the internal space, thereby inducing the opening of the outlet valve and the closing of the inlet valve and allowing the fluid reserved in the fluid reservoir to flow out through the outlet valve.

10. The device of claim 2, wherein the outlet valve, the inlet valve, or both of the outlet valve and the inlet valve have a pneumatic flap valve type.

11. The device of claim 2, wherein the outlet valve has an in-contact flap-stopper structure.

12. The device of claim 11, wherein the in-contact flap-stopper structure includes (i) an outlet valve flap plate having a flap that is openable and closable;

and (ii) a stopper plate closely adhering to the outlet valve flap plate, a pore of the stopper plate communicating with the flap of the outlet valve flap plate when the flap is opened and the fluid reservoir.

13. The device of claim 2, wherein the inlet valve has a not-contact flap-stopper structure.

14. The device of claim 13, wherein the not-contact flap-stopper structure includes (i) an inlet valve flap plate having a flap that is openable and closable;

(ii) a stopper plate having a pore communicating with the hollow microstructure; and

(iii) an intermediate plate disposed between the inlet valve flap plate and the stopper plate, a pore of the intermediate plate communicating with the flap of the inlet valve flap plate when the flap is opened and the pore of the stopper plate.

15. The device of claim 1, wherein the hollow microstructure is a hollow microstructure for minimally invasive blood extraction that has a length of 200-5000 μ

m, an inner diameter of 10-100 μ

m, a bevel angle of 5-60°

, a tip angle of 1-45°

, and a tip transverse length of 2-30 μ

m.

16. An integrated analysis system of body fluids, the system comprising the device for extraction of body fluids of claim 1;

and an analysis device of the body fluids.