Drug Delivery Apparatus and Method for Automatically Reducing Drug Dosage

• US 20140364839A1
• Filed: 05/15/2014
• Published: 12/11/2014
• Est. Priority Date: 08/27/2004
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medallion Therapeutics, Inc.
• Inventors: Shelton, Brian Michael
• Granted Patent: US 9,463,273 B2
• Time in Patent Office: Days
• US Class Current: 604/891.1
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence

Abstract

A drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump mechanism or valve, and a drug delivery control means: The drug delivery control means comprises a controller, e.g., a microprocessor or microcontroller which is operable to automatically reduce the rate of drug delivery over a certain reduction interval (e.g., multiple days) from an initial dosage value to a final dosage value.

Claims

1-16. -16. (canceled)

17. A method delivering drug with a drug delivery device located entirely within a patient, the method comprising the steps of:

wirelessly receiving delivery data with the drug delivery device located entirely within the patient; and

without receiving additional delivery data

(1) supplying drug to the patient for a period of at least 2 hours in accordance with a first stored delivery profile that includes a plurality of delivery times and a plurality of first delivery rates that correspond to the delivery times;

(2) after step (1), supplying drug to the patient for a period of at least 2 hours in accordance with a second stored delivery profile that includes a plurality of delivery times and a plurality of second delivery rates that correspond to the delivery times and are respectively lower than the first delivery rates, and

(3) after step (2), supplying drug to the patient for a period of at least 2 hours in accordance with a third stored delivery profile that includes a plurality of delivery times and a plurality of third delivery rates that correspond to the delivery times and are respectively lower than the second delivery rates.

18. A method as claimed in claim 17, wherein wirelessly receiving delivery data comprises wirelessly receiving a periodic reduction ratio with the drug delivery device located entirely within the patient.

19. A method as claimed in claim 17, wherein wirelessly receiving delivery data comprises wirelessly receiving a periodic reduction ratio, a reduction period, and a reduction interval with the drug delivery device located entirely within the patient.

20. A method as claimed in claim 17, wherein wirelessly receiving delivery data comprises wirelessly receiving data based on a current dosage, a final dosage, and a reduction rate with the drug delivery device located entirely within the patient.

21. A method as claimed in claim 17, wherein wirelessly receiving delivery data comprises wirelessly receiving data based on a current dosage value, a final dosage value, and a detoxification duration with the drug delivery device located entirely within the patient.

22. A method as claimed in claim 17, wherein the period during which drug is supplied to the patent in accordance with the first delivery profile is at least about 24 hours.

23. A method as claimed in claim 22, wherein the period during which drug is supplied to the patent in accordance with the second delivery profile is at least about 24 hours.

24. A method as claimed in claim 23, wherein the period during which drug is supplied to the patent in accordance with the third delivery profile is at least about 24 hours.

25. A method as claimed in claim 17, wherein at least two of the first delivery rates are different non-zero delivery rates.

26. A method as claimed in claim 17, wherein supplying drug to the patient comprises supplying drug to the patient with a pump mechanism.

27. A method delivering drug with a drug delivery device located entirely within a patient, the method comprising the steps of:

storing a 24-hour delivery profile that includes one or more delivery rates in the drug delivery device located entirely within the patient;

wirelessly receiving a final daily dosage value with the drug delivery device located entirely within the patient;

wirelessly receiving a reduction rate or a reduction interval with the drug delivery device located entirely within the patient; and

without receiving additional delivery profile information with the drug delivery device located entirely within the patient

delivering drug to the patient in accordance with the 24-hour delivery profile that include one or more delivery rates, and then

delivering drug to the patient in accordance with a reduced 24-hour delivery profile that includes one or more reduced delivery rates that are functions of the one or more delivery rates and either the transmitted final daily dosage value and the transmitted reduction rate or the transmitted final daily dosage value and the transmitted reduction interval, and then

delivering drug to the patient in accordance with a further reduced 24-hour delivery profile that includes one or more reduced delivery rates that are functions of the one or more reduced delivery rates and either the transmitted final daily dosage value and the transmitted reduction rate or the transmitted final daily dosage value and the transmitted reduction interval.

28. A method as claimed in claim 27, wherein the 24-hour delivery profile that includes at least two non-zero delivery rates that are different than one another.

29. A method as claimed in claim 27, wherein wirelessly receiving a reduction rate or a reduction interval comprises wirelessly receiving a reduction rate with the drug delivery device located entirely within the patient.

30. A method as claimed in claim 27, wherein wirelessly receiving a reduction rate or a reduction interval comprises wirelessly receiving a reduction interval with the drug delivery device located entirely within the patient.

31. A method as claimed in claim 27, wherein delivering drug to the patient comprises delivering drug to the patient with a pump mechanism.