BIODEGRADABLE MEDICAL ADHESIVE AND PREPARATION METHOD AND USE THEREOF
First Claim
Patent Images
1. A medical adhesive, comprising:
- a mono-α
-cyanoacrylate and a bis-α
-cyanoacrylic acid diol ester,wherein the structure of the mono-α
-cyanoacrylate is represented by Formula I;
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Abstract
A medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure.
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Citations
21 Claims
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1. A medical adhesive, comprising:
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a mono-α
-cyanoacrylate and a bis-α
-cyanoacrylic acid diol ester,wherein the structure of the mono-α
-cyanoacrylate is represented by Formula I; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 14, 15, 17, 18, 19, 20, 21)
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9. A method comprising the steps of:
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uniformly mixing a mono-α
-cyanoacrylate and a bis-α
-cyanoacrylic acid diol ester to form a medical adhesive;wherein the structure of the mono-α
-cyanoacrylate is represented by Formula I; - View Dependent Claims (10, 11)
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12. (canceled)
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13. A medical adhesive polymer, said medical adhesive polymer being obtained by crosslinking copolymerization of a medical adhesive under the action of anions,
wherein the medical adhesive comprises a mono-α - -cyanoacrylate and a bis-α
-cyanoacrylic acid diol ester,wherein the structure of the mono-α
-cyanoacrylate is represented by Formula I;
- -cyanoacrylate and a bis-α
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16. The medical adhesive according to claim 16, wherein, in the medical adhesive, the weight ratio of the mono-α
- -cyanoacrylate to the bis-α
-cyanoacrylic acid diol ester is 1;
1.
- -cyanoacrylate to the bis-α
Specification