Enhancing the Antimicrobial Activity of Biocides with Polymers

• US 20140369953A1
• Filed: 02/19/2013
• Published: 12/18/2014
• Est. Priority Date: 02/20/2012
• Status: Active Grant

• Current Assignee: BASF SE
• Original Assignee: BASF SE
• Inventors: Hffer, Stephan, Garcia Marcos, Alejandra, Hazenkamp, Menno, Purschwitz, Janina
• Granted Patent: US 11,647,746 B2
• Time in Patent Office: Days
• US Class Current: 424/78.36
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 31/04 Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
• CPC Class Codes: A01N 31/14 Ethers
• CPC Class Codes: A01N 31/16 with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
• CPC Class Codes: A01N 33/04 Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 33/20 containing oxygen or sulfur attached to the carbon skeleton containing the nitro group
• CPC Class Codes: A01N 35/02 containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
• CPC Class Codes: A01N 35/08 at least one of the bonds to hetero atoms is to nitrogen
• CPC Class Codes: A01N 37/02 Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/04 polybasic
• CPC Class Codes: A01N 43/64 having rings with three nitrogen atoms as the only ring hetero atoms
• CPC Class Codes: A01N 43/70 Diamino—1,3,5—triazines with only one oxygen, sulfur or halogen atom or only one cyano, thiocyano (—SCN), cyanato (—OCN) or azido (—N3) group directly attached to a ring carbon atom
• CPC Class Codes: A01N 43/88 six-membered rings with three ring hetero atoms
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: C08G 73/0206 Polyalkylene(poly)amines
• CPC Class Codes: C08K 5/0058 Biocides; macromolecular substances as carriers for biocide material A01N25/10
• CPC Class Codes: C08L 79/02 Polyamines

Abstract

Disclosed are compositions comprising a) an antimicrobial agent, which is selected from the group consisting of biocides containing halogen atoms and/or containing phenolic moieties, formic acid, chlorine dioxide, chlorine dioxide generating compounds, dialdehydes; components containing an antimicrobial metal such as antimicrobial silver, and b) a polyamine, especially a polyethylenimine. The polyamine is effective as a booster for the antimicrobial agent.

Claims

1. Composition comprising

a) an antimicrobial agent, which is selected from the group consisting of biocides containing halogen atoms and/or containing phenolic moieties, formic acid, chlorine dioxide, chlorine dioxide generating compounds, dialdehydes and components containing an antimicrobial metal, and

b) a polyamine.

2. Composition of claim 1, wherein the polyamine has a number-average molecular weight in the range from 500 to 2 000 000 g/mol.

3. Composition of claim 1, wherein the polyamine is selected from polyethyleneimines.

4. Composition according to claim 1, wherein the polyamine is selected from polycationic polymers having a charge density from the range 5 to 25 meq/g as measured at a pH of 4 to 5.

5. Composition according to claim 1, wherein component (a) is selected from the group of biocides consisting of phenoxyethanol, 2-bromo-2-nitropropane-1,3-diol, 4,4′

-dichloro-2′

-hydroxydiphenylether, 2,4,4′

-trichloro-2′

-hydroxy-diphenyl ether, glutaraldehyde, formic acid, 1,2-ethanedial, 2,4-dichlorobenzyl alcohol, 3,5-dimethyl-1,3-5-thiadiazinane-2-thione, 1,3,5-tris-(2-hydroxyethyl)hexahydro-1,3,5-triazine, 2-methylthio-4-tert-butylamino cyclopropylamino-6-(1,3,5-triazine), silver-glass and silver zeolite.

6. Composition according to claim 1 comprising on 1 part by weight of the biocide (a) 0.001 to 1000, parts by weight of component (b).

7. Composition according to claim 1, which composition contains 0.001 to 5% b.w. of the biocide (a), relative to the total weight of the composition.

8. Composition according to claim 1, wherein the polyamine is a homopolymer, or an oligomer or polymer grafted with 0.01 to 100 parts by weight of ethylene oxide on 1 part by weight of the polyamine.

9. Composition according to claim 1, wherein the polyamine is a branched polyethylenimine homopolymer, whose uncharged form conforms to the empirical formula —

(CH₂—

CH₂—

NH)_n—

wherein n ranges from approximately 10 to 100000, or is a grafted variant thereof.

10. Composition according to claim 1, comprising at least one further component selected from the group consisting of surface active agents, hydrotropic agents, further additives that improve the antimicrobial effect, and agents stabilizing the antimicrobial agent (a) and/or the polyamine (b) in the formulation.

11. Composition according to claim 10, which composition contains 0.001 to 80% b.w. of a surface active agent, relative to the total weight of the composition.

12. A method for enhancing the antimicrobial activity of a biocide described in claim 1, which method comprises incorporation of a polyamine as described in claim 1 and optionally a further component selected from the group consisting of surface active agents, hydrotropic agents, further additives that improve the antimicrobial effect, and agents stabilizing the antimicrobial agent (a) into the biocidal formulation.

14. A method of manufacturing a home care formulation, selected from the group consisting of a disinfectant, all purpose cleaner, laundry detergent, dishwashing liquid, deodorant, fabric conditioner, product for disinfection and sanitization of hard surfaces, floor cleaner, glass cleaner, kitchen cleaner, bath cleaner, sanitary cleaner, hygiene rinse product for fabrics, carpet cleaner, furniture cleaner, or a product for conditioning, sealing, caring or treating hard and soft surfaces;

or a personal care formulation, selected from the group consisting of a deodorant, skin care preparation, bath preparation, cosmetic care preparation, foot-care preparation, light-protective preparation, skin-tanning preparation, depigmenting preparation, insect-repellent, antiperspirant, preparation for cleansing and caring for blemished skin, hair-removal preparation, shaving preparation, fragrance preparation, cosmetic hair-treatment preparation, antidandruff preparation and oral care composition by adding to the home care formulation or personal care formulation the composition according to claim 1.

13. (canceled)

15. (canceled)