PROTEIN DELIVERY FROM STEM CELL MICROCARRIERS
2 Assignments
0 Petitions
Accused Products
Abstract
Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof.
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Citations
112 Claims
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1-36. -36. (canceled)
- 37. A composition comprising injectable biodegradable polymeric hydrogel microbeads, wherein the microbeads comprise mesenchymal stem cells wherein the expression, production, or secretion of an angiogenic factor or a hypertrophic factor or both by the mesenchymal stem cells is inhibited by contact with chondrogenic medium, or the expression, production, or secretion of a chondrogenic factor or an anti-hypertrophic factor or both by the mesenchymal stem cells is stimulated by contact with chondrogenic medium.
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46-54. -54. (canceled)
- 55. A method of repairing cartilage in a subject diagnosed with diseased or damaged cartilage, comprising administering to a subject a therapeutically effective amount of a composition comprising injectable biodegradable polymeric hydrogel microbeads, wherein the microbeads comprise mesenchymal stem cells, wherein the expression, production, or secretion of an angiogenic factor or a hypertrophic factor or both by the mesenchymal stem cells is inhibited by contact with chondrogenic medium, or the expression, production, or secretion of a chondrogenic factor or an anti-hypertrophic factor or both by the mesenchymal stem cells is stimulated by contact with chondrogenic medium.
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62-108. -108. (canceled)
Specification