ELECTROLYTIC BIOSENSOR

• US 20140371550A1
• Filed: 04/19/2012
• Published: 12/18/2014
• Est. Priority Date: 04/22/2011
• Status: Abandoned Application

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Hoffman, Justin Lyle, Horwath, Michael John, Haumann, Karin, Schmidt, Jennifer Stephanie, DeArmond, Daniel Thomas
• Application Number:
  US14/113,347
• Publication Number:
  US 20140371550A1
• Time in Patent Office: Days
• US Class Current: 600/302
• CPC Class Codes: A61B 5/02042 Determining blood loss or bleeding, e.g. during a surgical procedure
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61M 27/00 Drainage appliance for wounds or the like , i.e. wound drains, implanted drains negative pressure wound therapy devices A61M1/90; implements for holding wound open A61B17/02 ; middle ear drainage A61F11/202

Abstract

An electrolytic biosensor for use in intracorporeal leak detection may be incorporated into a surgical drain that is installed post-operatively at the site of a wound. The electrolytic biosensor may be used to monitor drain effluent flowing through the surgical drain by measuring a fluid conductivity of the drain effluent. Certain changes, patterns, or responses of the so measured fluid conductivity values may be indicative of a physiological condition of the wound. For example, when the wound is a gastrointestinal anastomosis, the fluid conductivity values measured with the electrolytic biosensor may be used to characterize a fluid integrity of the gastrointestinal anastomosis. An electrolytic biosensor system may include an application that records conductivity data and provides notifications, such as a patient alarm, when a leak is detected.

Claims

1. An electrolytic biosensor device, comprising:

a processor configured to access memory media; and

a wireless interface,

wherein the memory media store processor instructions executable by the processor to;

balance a bridge circuit that includes a probe installed in a surgical drain at an intracorporeal wound site;

acquire conductivity values from the bridge circuit corresponding to conductivity of a drain effluent in contact with the probe when flowing through the surgical drain;

store the conductivity values; and

transmit the conductivity values via the wireless interface.

2. The electrolytic biosensor device of claim 1, wherein the electrolytic biosensor device is incorporated into the surgical drain.

3. The electrolytic biosensor device of claim 1, further comprising:

the bridge circuit;

a sensor interface coupling the bridge circuit to the probe; and

a power source configured to drive the sensor interface.

4. The electrolytic biosensor device of claim 3, further comprising:

a power control module configured to switch connections to the sensor interface.

5. The electrolytic biosensor device of claim 1, wherein the processor instructions executable to acquire the conductivity values include processor instructions executable to:

perform digital signal processing on output signals from the bridge circuit.

6. The electrolytic biosensor device of claim 1, including processor instructions executable to:

based on the conductivity values, determine wound integrity; and

transmit an indication of the wound integrity via the wireless interface.

7. A method of detecting wound integrity using an electrolytic biosensor, comprising:

determining an expected ingestion profile for a patient ingesting a trace fluid, including estimating a conductivity change over time at a gastrointestinal wound site of the patient;

responsive to receiving an indication of the ingesting of the trace fluid, collecting ingestion profile conductivity data using an electrolytic probe at the gastrointestinal wound site of the patient, wherein the electrolytic probe is installed in a surgical drain and is configured to measure conductivity of an effluent fluid flowing from the gastrointestinal wound site through the surgical drain; and

analyzing the ingestion profile conductivity data to determine fluid integrity of the gastrointestinal wound site, including comparing the ingestion profile conductivity data with the expected ingestion profile.

8. The method of claim 7, wherein the trace fluid has a substantially higher conductivity than a nominal conductivity value of the effluent fluid, and wherein the conductivity change is a substantial increase in conductivity.

9. The method of claim 7, wherein the determining the expected ingestion profile includes:

using a physiological model describing specific attributes of the patient; and

estimating a degree of leakage at the gastrointestinal wound site.

10. The method of claim 7, wherein collecting ingestion profile conductivity data includes storing ingestion profile conductivity data, and wherein analyzing the ingestion profile conductivity data includes comparing new ingestion profile conductivity data to previously stored ingestion profile conductivity data.

11. The method of claim 7, further comprising:

wirelessly transmitting an indication of the fluid integrity of the gastrointestinal wound site to a wireless user device.

12. The method of claim 7, further comprising:

transmitting an indication of the fluid integrity of the gastrointestinal wound site to a server via a network.

13. The method of claim 7, wherein analyzing the ingestion profile conductivity data to determine fluid integrity of the gastrointestinal wound site includes:

determining a degree of leakage at the gastrointestinal wound site.

14. The method of claim 13, further comprising:

based on the degree of leakage, generating an alarm associated with the patient.

15. A non-transitory computer readable memory media storing processor instructions executable by a processor to operate an electrolytic biosensor device, the processor instructions including instructions executable to:

balance a bridge circuit that includes an electrolytic probe installed in a surgical drain at an intracorporeal wound site of a patient, wherein the electrolytic probe includes a conductivity cell for measuring conductivity;

acquire conductivity data from the bridge circuit corresponding to conductivity of a drain effluent flowing through the conductivity cell;

determine fluid integrity of the intracorporeal wound site by comparing the conductivity data with previously-stored reference conductivity data; and

transmit an indication of the fluid integrity of the intracorporeal wound site.

16. The memory media of claim 15, wherein the processor instructions executable to acquire the conductivity data include processor instructions executable to:

control a sensor interface to the conductivity cell; and

process an output signal from the conductivity cell to generate the conductivity data.

17. The memory media of claim 15, including processor instructions executable to:

based on the indication of the fluid integrity of the intracorporeal wound site, generate an alarm associated with the patient.

18. The memory media of claim 15, wherein the processor instructions executable to transmit an indication of the fluid integrity include processor instructions executable to:

send a wireless message to a wireless user device.

19. The memory media of claim 15, including processor instructions executable to:

transmit the conductivity data for the patient to a server.

20. The memory media of claim 15, wherein the processor instructions executable to compare the conductivity data with previously-stored reference conductivity data include processor instructions executable to:

retrieve reference conductivity data for the patient.