Symmetrically Arranged Sensor Electrodes in an Ophthalmic Electrochemical Sensor

• US 20140371558A1
• Filed: 06/17/2013
• Published: 12/18/2014
• Est. Priority Date: 06/17/2013
• Status: Active Grant

• Current Assignee: Google LLC (Alphabet Inc.)
• Original Assignee: Google Inc. (Alphabet Inc.)
• Inventors: Etzkorn, James, Liu, Zenghe
• Granted Patent: US 9,084,561 B2
• Time in Patent Office: Days
• US Class Current: 600/345
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1477 non-invasive
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: G01N 27/30 Electrodes, e.g. test electrodes; Half-cells G01N27/414 takes precedence
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001
• CPC Class Codes: G01N 27/4166 measuring a particular property of an electrolyte
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00

Abstract

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.

Claims

1. An eye-mountable device comprising:

a polymeric material having a concave surface and a convex surface, wherein the concave surface is configured to be removably mounted over a corneal surface and the convex surface is configured to be compatible with eyelid motion when the concave surface is so mounted;

a substrate at least partially embedded within the polymeric material;

an antenna disposed on the substrate;

an electrochemical sensor disposed on the substrate and including (i) a working electrode having a first side edge and a second side edge, and (ii) a reference electrode situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode; and

a controller electrically connected to the electrochemical sensor and the antenna, wherein the controller is configured to;

(i) apply a voltage between the working electrode and the reference electrode sufficient to generate an amperometric current related to the concentration of an analyte in a fluid to which the eye-mountable device is exposed;

(ii) measure the amperometric current; and

(iii) use the antenna to indicate the measured amperometric current,

wherein the substrate is a ring-like structure having inner and outer edges,

wherein the working electrode and the reference electrode each include a plurality of interdigitated extensions oriented on the substrate to be locally parallel to the inner and outer edges of the ring-like structure at one or more locations along the interdigitated extensions.

2. The eye-mountable device according to claim 1, wherein the working electrode includes a plurality of extensions extending from a base, and wherein each of the plurality of extensions includes a first side edge and a second side edge that are at least partially adjacent to respective sections of the reference electrode.

3. The eye-mountable device according to claim 2, wherein the plurality of extensions of the working electrode and the respective sections of the reference electrode are interdigitated with one another.

4. The eye-mountable device according to claim 1, wherein the respective sections of the reference electrode adjacent the working electrode are arranged symmetrically along the first and second side edges of the working electrode such that while the voltage is applied, a resulting voltage gradient is substantially symmetric along the first and second side edges of the working electrode.

5. The eye-mountable device according to claim 1, wherein the working electrode and the reference electrode are substantially co-planar.

6. The eye-mountable device according to claim 5,

wherein the working electrode and the reference electrode are arranged as substantially parallel interdigitated extensions, and

wherein the working electrode includes an extension that is approximately equidistant respective extensions of the reference electrode such that while the voltage is applied, a resulting voltage gradient along opposing side edges of the extension is substantially symmetric between the opposing side edges.

7. The eye-mountable device according to claim 5,

wherein the working electrode and the reference electrode are arranged as substantially concentric partial rings, and

wherein the working electrode includes a partial ring that is approximately equidistant respective partial rings of the reference electrode, along a radial direction of the concentric arrangement, such that while the voltage is applied, a resulting voltage gradient along opposing circular side edges of the working electrode partial ring is substantially symmetric between the opposing circular side edges.

8. The eye-mountable device according to claim 1,

wherein the inner edge and the outer edge are substantially concentric rings centered about an axis of symmetry of the convex and concave surfaces of the polymeric material.

9. The eye-mountable device according to claim 1, wherein the polymeric material includes a channel configured to expose the working electrode and reference electrode to tear film coating the polymeric material.

10. The eye-mountable device according to claim 9, wherein the channel exposes a region occupied by one or more extensions of the working electrode having a combined length of about 1 millimeter.

11. The eye-mountable device according to claim 1, wherein the working electrode has at least one dimension that is about 25 micrometers or less.

12. The eye-mountable device according to claim 11, wherein the at least one dimension of the working electrode is a width between the first side edge and the second side edge.

13. The eye-mountable device according to claim 11, wherein the respective sections of the reference electrode situated adjacent the working electrode have an area that is at least about five times an area of the working electrode.

14. The eye-mountable device according to claim 1, further comprising a reagent that selectively reacts with the analyte, wherein the reagent is localized proximate the working electrode.

15. The eye-mountable device according to claim 1, wherein the polymeric material is a substantially transparent vision correction lens and is shaped to provide a predetermined vision-correcting optical power.

16. A system comprising:

an eye-mountable device including;

a transparent polymeric material having a concave surface and a convex surface, wherein the concave surface is configured to be removably mounted over a corneal surface and the convex surface is configured to be compatible with eyelid motion when the concave surface is so mounted;

a substrate at least partially embedded within the polymeric material;

an antenna disposed on the substrate;

an electrochemical sensor disposed on the substrate and including (i) a working electrode having a first side edge and a second side edge, and (ii) a reference electrode situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode; and

a controller electrically connected to the electrochemical sensor and the antenna, wherein the controller is configured to;

(i) apply a voltage between the working electrode and the reference electrode sufficient to generate an amperometric current related to the concentration of an analyte in a fluid to which the eye-mountable device is exposed;

(ii) measure the amperometric current; and

(iii) use the antenna to indicate the measured amperometric current; and

a reader including;

one or more antennas configured to;

(i) transmit radio frequency radiation to power the eye-mountable device, and (ii) receive indications of the measured amperometric current via backscatter radiation received at the one or more antennas; and

a processing system configured to determine a tear film analyte concentration value based on the backscatter radiation,

wherein the substrate is a ring-like structure having inner and outer edges,

wherein the working electrode and the reference electrode each include a plurality of interdigitated extensions oriented on the substrate to be locally parallel to the inner and outer edges of the ring-like structure at one or more locations along the interdigitated extensions.

17. The system according to claim 16, wherein the interdigitated extensions of the working electrode extend from a base.

18. The system according to claim 16, wherein the respective sections of the reference electrode adjacent the working electrode are arranged symmetrically along the first and second side edges of the working electrode such that while the voltage is applied, a resulting voltage gradient is substantially symmetric along the first and second side edges of the working electrode.

19. A device comprising:

a bio-compatible polymeric material;

a substrate at least partially embedded within the bio-compatible polymeric material;

an antenna disposed on the substrate;

an electrochemical sensor disposed on the substrate and including (i) a working electrode having a first side edge and a second side edge, and (ii) a reference electrode situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode; and

a controller electrically connected to the electrochemical sensor and the antenna, wherein the controller is configured to;

(i) apply a voltage between the working electrode and the reference electrode sufficient to generate an amperometric current related to the concentration of an analyte in a fluid to which the eye-mountable device is exposed;

(ii) measure the amperometric current; and

(iii) use the antenna to indicate the measured amperometric current,

wherein the substrate is a ring-like structure having inner and outer edges,

wherein the working electrode and the reference electrode each include a plurality of interdigitated extensions oriented on the substrate to be locally parallel to the inner and outer edges of the ring-like structure at one or more locations along the interdigitated extensions.

20. The device according to claim 19, wherein the respective sections of the reference electrode adjacent the working electrode are arranged symmetrically along the first and second side edges of the working electrode such that while the voltage is applied, a resulting voltage gradient is substantially symmetric along the first and second side edges of the working electrode.