METALLIC STRUCTURES HAVING POROUS REGIONS FROM IMAGED BONE AT PRE-DEFINED ANATOMIC LOCATIONS

• US 20140371863A1
• Filed: 09/03/2014
• Published: 12/18/2014
• Est. Priority Date: 07/20/2012
• Status: Active Grant

• Current Assignee: Biomet Manufacturing, LLC (Zimmer Biomet Holdings, Inc.)
• Original Assignee: Biomet Manufacturing, LLC (Zimmer Biomet Holdings, Inc.)
• Inventors: Gupta, Gautam, Meridew, Jason, VANASSE, TOM
• Granted Patent: US 9,993,341 B2
• Time in Patent Office: Days
• US Class Current: 623/18.11
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/30942 for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
• CPC Class Codes: A61F 2/4003 Replacing only the epiphyseal or metaphyseal parts of the humerus, i.e. endoprosthesis not comprising an entire humeral shaft replacing only the epiphyseal or metaphyseal parts of the femur A61F2/3601
• CPC Class Codes: A61F 2002/30011 differing in porosity
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2002/30943 using mathematical models
• CPC Class Codes: A61F 2002/30948 using computerized tomography, i.e. CT scans
• CPC Class Codes: A61F 2002/30962 using stereolithography
• CPC Class Codes: A61F 2002/30968 Sintering
• CPC Class Codes: A61F 2002/3097 using laser
• CPC Class Codes: A61F 2002/30971 Laminates, i.e. layered products
• CPC Class Codes: A61F 2002/30985 using three dimensional printing [3DP]
• CPC Class Codes: B33Y 50/00 Data acquisition or data processing for additive manufacturing
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: Y10T 29/49 Method of mechanical manufacture

Abstract

An additively manufactured medical implant, comprising a metallic body having at least one porous surface configured to promote bony on-growth or in-growth of tissue, the porous surface being replicated from a high resolution scan of bone, and a biological surface coating configured to create a barrier to particulate debris, the biological surface coating being produced from a titanium porous plasma spray surface coating or a biomimetic coating.

Claims

1. A medical implant, comprising:

a metallic body having at least one surface replicated from a high resolution scan of bone and configured to promote bony on-growth or in-growth of tissue;

wherein the implant is generated using an additive manufacturing technique.

2. The medical implant of claim 1, further comprising a biological surface coating configured to create a barrier to particulate debris.

3. The medical implant of claim 1, wherein the biological surface coating is a titanium porous plasma spray surface coating or a biomimetic coating.

4. The medical implant of claim 3, wherein the biological surface coating is capable of exhibiting an enhanced biological performance when subjected to at least one of grit blasting, hyaluronic acid (HA), an RGD-containing glycoprotein or bend coating.

5. The medical implant of claim 1, wherein the at least one surface is a porous surface.

6. The medical implant of claim 1, wherein the additive manufacturing technique used to generate the implant is selected from a Direct Metal Laser Sintering (DMLS) process or an Electron Beam Melting (EBM) process, Selective Laser Sintering (SLS), Fused Deposition Modeling (FDM), Stereolithography (SLA), Laminated Object Manufacturing, Powder Bed and Inkjet Head 3D Printing and Plaster-Based 3D Printing (PP).

7. The medical implant of claim 1, wherein the high resolution scan of the bone comprises a scan that was imaged with a computed tomography (CT) scanner.

8. The medical implant of claim 1, wherein the implant is configured to be implanted into a hip, shoulder, knee, spine, elbow, wrist, ankle, finger or toe.

9. An additively manufactured medical implant, comprising:

a metallic body having at least one porous surface configured to promote bony on-growth or in-growth of tissue, the porous surface being replicated from a high resolution scan of bone; and

a biological surface coating configured to create a barrier to particulate debris, the biological surface coating being produced from a titanium porous plasma spray surface coating or a biomimetic coating;

wherein the medical implant is produced from the steps of;

imaging bone with a high resolution digital scanner to generate a three-dimensional design model of the bone;

removing a three-dimensional section from the design model;

fabricating a porous region on a digital representation of the implant by replacing a solid portion of the digital implant with the section removed from the design model; and

using an additive manufacturing technique to create a physical implant including the fabricated porous region.

10. The additively manufactured medical implant of claim 9, wherein the production step of imaging the bone with a high resolution digital scanner comprises scanning the bone with a computed tomography (CT) scanner.

11. The additively manufactured medical implant of claim 10, wherein the production step of scanning the bone with a computed tomography (CT) scanner comprises scanning the bone with a MicroCT scanner.

12. The additively manufactured medical implant of claim 9, further comprising the production step of modifying any artifacts from the three-dimensional design model of the bone.

13. The additively manufactured medical implant of claim 12, wherein the production step of modifying any artifacts from the three-dimensional design model comprises removing defective regions of the design model containing non-uniformities or discontinuities by filling the defective regions with a selected and superimposed region of the bone model that does not contain a non-uniformity or a discontinuity.

14. The additively manufactured medical implant of claim 9, further comprising the production step of converting the imaged bone to a digital file format.

15. The additively manufactured medical implant of claim 9, wherein the production step of fabricating a porous region on a digital representation of the implant comprises utilizing a computer aided design (CAD) program to fabricate a porous region that structurally replicates the architecture of the bone, the porous region being selected from one of a hip, shoulder, knee, spine, elbow, wrist, ankle, finger and toe.

16. The additively manufactured medical implant of claim 9, wherein the production step of using an additive manufacturing technique to create a physical implant comprises using a Direct Metal Laser Sintering (DMLS) process or an Electron Beam Melting (EBM) process, Selective Laser Sintering (SLS), Fused Deposition Modeling (FDM), Stereolithography (SLA), Laminated Object Manufacturing, Powder Bed and Inkjet Head 3D Printing and Plaster-Based 3D Printing (PP).

17. The additively manufactured medical implant of claim 9, further comprising the production step of performing an additional manufacturing process on the physical implant to modify one or more features, the manufacturing process being selected from at least one of casting, molding, forming, machining, joining, polishing, blasting and welding.

18. An additively manufactured medical implant, comprising:

a metallic body having at least one porous surface configured to promote bony on-growth or in-growth of tissue, the porous surface being replicated from a high resolution scan of bone; and

a biological surface coating configured to create a barrier to particulate debris, the biological surface coating being produced from a titanium porous plasma spray surface coating or a biomimetic coating;

wherein the medical implant is produced from the steps of;

creating a digital image of the bone with a microCT scanner;

removing any defective artifacts from the digital image;

converting the digital image to a three-dimensional design model of the bone;

removing a three-dimensional section that structurally replicates the architecture of the bone from the design model;

printing the removed design model section on a digital representation of the implant; and

creating a physical implant from the printed digital representation by using an additive manufacturing technique.

19. The additively manufactured medical implant of claim 18, wherein the production step of printing the removed design model section on a digital representation of the implant comprises using a computer aided design (CAD) program to print the removed design model section.

20. The additively manufactured medical implant of claim 18, wherein the production step of removing any defective artifacts comprises removing any defective regions containing a non-uniformity or discontinuity from the image by filling the defective regions with a selected and superimposed region of the digital image that does not contain a non-uniformity or a discontinuity.

21. The additively manufactured medical implant of claim 18, wherein the production step of creating a physical implant from the printed digital representation by using an additive manufacturing technique comprises using a Direct Metal Laser Sintering (DMLS) process or an Electron Beam Melting (EBM) process, Selective Laser Sintering (SLS), Fused Deposition Modeling (FDM), Stereolithography (SLA), Laminated Object Manufacturing, Powder Bed and Inkjet Head 3D Printing and Plaster-Based 3D Printing (PP).

22. The additively manufactured medical implant of claim 18, further comprising the production step of performing an additional manufacturing process on the physical implant to add one or more features, the manufacturing process being selected from at least one of casting, molding, forming, machining, joining, polishing, blasting and welding.

23. An additively manufactured medical implant to fill a bone void, comprising:

a metallic body having at least one porous surface configured to promote bony on-growth or in-growth of tissue, the porous surface being replicated from a high resolution scan of bone; and

a biological surface coating configured to create a barrier to particulate debris, the biological surface coating being produced from a titanium porous plasma spray surface coating or a biomimetic coating;

wherein the medical implant is produced from the steps of;

imaging a voided bone region with a high resolution digital scanner to generate a three dimensional design model of the voided bone region;

providing a digital representation of a non-voided bone region;

removing a three dimensional section of the non-voided bone region, the removed section having a size that substantially matches the size of the voided bone region; and

creating a physical implant from the removed three dimensional section of the non-voided bone region by using an additive manufacturing technique, the implant being configured to be installed within the voided bone region.