RNA-GUIDED TARGETING OF GENETIC AND EPIGENOMIC REGULATORY PROTEINS TO SPECIFIC GENOMIC LOCI
First Claim
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1. A fusion protein comprising catalytically inactive CRISPR associated 9 (Cas9) protein linked to a heterologous functional domain.
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Abstract
Methods and constructs for RNA-guided targeting of transcriptional activators to specific genomic loci.
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17 Claims
- 1. A fusion protein comprising catalytically inactive CRISPR associated 9 (Cas9) protein linked to a heterologous functional domain.
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