APPARATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE

• US 20140378797A1
• Filed: 01/22/2013
• Published: 12/25/2014
• Est. Priority Date: 01/27/2012
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Hendriks, Bernardus Hendrikus Wilhelmus, Nachabe, Rami, Ruers, Theodoor Jacques Marie, Lucassen, Gerhardus Wilhelmus, Horikx, Jeroen Jan Lambertus, Mueller, Manfred, Van Der Voort, Marjolein, Spliethoff, Jarich Willem
• Application Number:
  US14/374,626
• Publication Number:
  US 20140378797A1
• Time in Patent Office: Days
• US Class Current: 600/342
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/4381 Prostate evaluation or disorder diagnosis
• CPC Class Codes: G01N 23/00 Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
• CPC Class Codes: G01N 33/50 Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing measuring or testing processes involving enzymes or microorganisms, compositions or test papers therefor; processes for forming such compositions, condition responsive control in microbiological or enzymological processes C12Q

Abstract

The present invention relates to an apparatus 100 and, a method and a computer program for determining a first parameter indicative of a concentration of lycopene. In particular, the invention relates to an apparatus 100 comprising a spectrometer 02, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum via an interventional device 112. This enables determination of a first parameter being indicative of a lycopene concentration. Lycopene concentration may serve as a discriminative feature for different tissue types, such as the prostate organ and associated structures. The apparatus may in a specific embodiment be arranged to determine a second parameter indicative of a tissue type based on a concentration of lycopene. According to a specific embodiment, the apparatus relies on Diffuse Reflectance Spectroscopy (DRS).

Claims

1. An apparatus for optical analysis of an associated tissue, the apparatus comprising:

a spectrometer for obtaining measured data representative of an optical spectrum of the associated tissue, the spectrometer comprising

a light source,

an optical detector,

 

an interventional device suitable for insertion into the associated tissue (116), the interventional device comprising

one or more guides for

guiding photons from the light source to an exit position on a distal end of the interventional device, the photons being emittable from the exit position, and for

guiding photons from an entry position on the distal end of the interventional device and to the optical detector,

so as to enable obtaining the measured data representative of the optical spectrum of the associated tissue at a position of the distal end of the interventional device, and

a processor arranged for

receiving the measured data,

determining from the data a first parameter being indicative of a concentration of lycopene in said associated tissue

wherein the processor is further arranged for determining from the first parameter a second parameter being indicative of a tissue type.

3. An apparatus according to claim 1, wherein the apparatus is arranged for obtaining measured data representative of the optical spectrum, wherein the optical spectrum is a Diffuse Reflectance Spectrum.

4. An apparatus according to claim 1, wherein the exit position and the entry position being positioned with sufficient relative distance for Diffusive Reflectance Spectrometry to be performed.

5. An apparatus according to claim 1, wherein the processor is further arranged for determining one or more third parameters, wherein each of the one or more third parameters is indicative of a concentration of a chromophore other than lycopene in said associated tissue.

6. An apparatus according to claim 1, wherein the processor is further arranged for determining a scattering parameter based on the measured data.

7. An apparatus according to claim 1, wherein the one or more guides comprising—

a first guide for guiding photons from the light source to an exit position on a distal end of the interventional device, the photons being emittable from the exit position, and

a second guide for guiding photons from an entry position on the distal end of the interventional device and to the optical detector.

8. An apparatus according to claim 1, wherein the exit position and the entry position are spatially separated and spatially oriented so that, upon positioning the distal end of the interventional device adjacent to the associated tissue the photons emittable at the exit position and subsequently collectable at the entry position are diffusive photons which experience multiple scattering events.

9. An apparatus according to claim 1, wherein the exit position and the entry position are spatially separated and spatially oriented so that, upon positioning the distal end of the interventional device adjacent to the associated tissue, the entry position is not intersected by ballistic photons emitted from the exit position, when the distal end of the interventional device is placed adjacent the associated sample.

10. An apparatus according to claim 1, wherein the apparatus further comprises a database, which database is operably connected to the processor.

11. An apparatus according to claim 10, wherein the database comprises predetermined data representative of one or more optical spectra, wherein one predetermined data is representative of an optical spectrum of lycopene.

2. (canceled)

12. A method for optical analysis of an associated tissue, the method comprising the steps of:

measuring data representative of an optical spectrum of the associated tissue by emitting and receiving photons via an interventional device,

determination of a first parameter, the first parameter being indicative of a concentration of lycopene, based on the optical spectrum

determination of a second parameter based on the first parameter, the second parameter being indicative of a tissue type.

14. A method according to claim 12 for optical analysis of an associated tissue, wherein the determination of the first parameter includes any one of:

fitting the measured data to a mathematical model,

accessing a look-up-table comprising one or more predetermined optical spectra, and

performing multivariate analysis.

15. A computer program product being adapted to enable a computer system comprising at least one computer having data storage means associated therewith to operate a processor arranged for carrying out the method according to claim 12.

13. (canceled)